Table of Contents

1. Untranslated gene regions and other non-coding elements. 1. Introduction.
2. Promoter. 2.1 Types of promoter; 2.2 Complex factor interactions; 2.3 Alternative promoters; 2.4 Bidirectional promoters.
3. 5' untranslated region. 3.1 Structure ; 3.2 Regulatory motifs.
4. Intronic regions. 4.1 Organization and length; 4.2 Introns in the UTRs; 4.3 Intron function; 4.4 Regulatory elements: enhancers.
5. 3' Untranslated region. 5.1 MicroRNAs and the 3'UTR; 5.2 stabilisation and AU-rich elements; 5.3 Structure.
6. Non-coding RNAs. 6.1 Promoter associated RNAs (PROMPTs); 6.2 Short Interfering RNA (siRNA); 6.3 Piwi-interacting RNAs (piRNAs); 6.4 Small nuclear RNA (snRNA); 6.5 Cis-natural antisense transcripts; 6.6 Long non-coding RNAs; 6.7 RNAs as extracellular signalling molecules; 6.8 Pseudogenes and non-coding RNA; 6.9 Non-coding capacity in primates; 6.10 Competing endogenous RNAs; 6.11 Chimeric RNAs. Preface; Contents; 1 Untranslated gene regions and other non-coding elements; Abstract; 1{u2026}Introduction; 2{u2026}Promoter; 2.1 Types of promoter; 2.1.1 Focused promoters; 2.1.2 Dispersed promoters; 2.2 Complex factor interactions; 2.3 Alternative promoters; 2.4 Bidirectional promoters; 2.5 Conclusion; 3{u2026}5vprime untranslated region; 3.1 Structure; 3.1.1 5vprime cap structure; 3.1.2 Secondary structure; 3.1.3 G-Quadruplexes; 3.1.4 Alternative 5vprimeUTRs; 3.2 Regulatory motifs; 3.2.1 IRES and cap-independent translation initiation; 3.2.2 uORFs; 3.3 Conclusion; 4{u2026}Intronic regions 4.1 Organization and length4.2 introns in the UTRs; 4.3 Intron function; 4.4 Regulatory elements: enhancers; 5{u2026}3vprime Untranslated region; 5.1 MicroRNAs and the 3vprimeUTR; 5.2 stabilisation and AU-rich elements; 5.3 structure; 5.3.1 Poly(A) Tail; 5.3.2 5vprime.
3vprime interactions; 5.3.3 length; 5.3.4 secondary structure; 5.3.5 Alternative 3vprimeUTRs; 5.4 Conclusions; 6{u2026}Non-coding RNAs; 6.1 Promoter associated RNAs (PROMPTs); 6.2 Short Interfering RNA (siRNA); 6.3 Piwi-interacting RNAs (piRNAs); 6.4 Small nuclear RNA (snRNA); 6.5 Cis-natural antisense transcripts; 6.6 Long non-coding RNAs 6.7 RNAs as extracellular signalling molecules6.8 Pseudogenes and non-coding RNA; 6.9 Non-coding capacity in primates; 6.10 Competing endogenous RNAs; 6.11 Chimeric RNAs; 7{u2026}Conclusion; References "There is now compelling evidence that the complexity of higher organisms correlates with the relative amount of non-coding RNA rather than the number of protein-coding genes. Previously dismissed as ""junk DNA"", it is the non-coding regions of the genome that are responsible for regulation, facilitating complex temporal and spatial gene expression through the combinatorial effect of numerous mechanisms and interactions working together to fine-tune gene expression. The major regions involved in regulation of a particular gene are the 5' and 3' untranslated regions and introns. In addition, pervasive transcription of complex genomes produces a variety of non-coding transcripts that interact with these regions and contribute to regulation. This book discusses recent insights into the regulatory roles of the untranslated gene regions and non-coding RNAs in the control of complex gene expression, as well as the implications of this in terms of organism complexity and evolution"--From ebook's opening screen (EBL platform, viewed October 9, 2013).