Terkko Navigator / Toxicology

The effect of dermal benzophenone-2 administration on immune system activity, hypothalamic-pituitary-thyroid axis activity and hematological parameters in male Wistar rats

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The impact of chemotherapeutic drugs on the CYP1A1-catalysed metabolism of the environmental carcinogen benzo[a]pyrene: Effects in human colorectal HCT116 TP53(+/+), TP53(+/−) and TP53(−/−) cells

Neuroreflex control of cardiovascular function is impaired after acute poisoning with chlorpyrifos, an organophosphorus insecticide: Possible short and long term clinical implications

Lead exposure inhibits expression of SV2C through NRSF

Cadmium exposure exacerbates hyperlipidemia in cholesterol-overloaded hepatocytes via autophagy dysregulation

Calpeptin is neuroprotective against acrylamide-induced neuropathy in rats

Developmental Neurotoxicity Resulting from Pharmacotherapy of Preterm Labor, Modeled In Vitro: Terbutaline and Dexamethasone, Separately and Together

Cigarette smoke-induced inflammation: NLRP10-mediated mechanisms

Orally administered nicotine effects on rat urinary bladder proliferation and carcinogenesis

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Natural product andrographolide alleviated APAP-induced liver fibrosis by activating Nrf2 antioxidant pathway

Evaluation of the treatment with resveratrol-loaded nanoparticles in intestinal injury model caused by ischemia and reperfusion

Comparison of the effects of sodium phenobarbital in wild type and humanized constitutive androstane receptor (CAR)/pregnane X receptor (PXR) mice and in cultured mouse, rat and human hepatocytes

Mitochondrial dysfunction induced by leflunomide and its active metabolite

CLARITY-BPA: Effects of chronic Bisphenol A exposure on the immune system: Part 1– Quantification of the relative number and proportion of leukocyte populations in the spleen and thymus

CLARITY-BPA: Effects of chronic bisphenol A exposure on the immune system: Part 2– Characterization of lymphoproliferative and immune effector responses by splenic leukocytes

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Incorporating population-level genetic variability within laboratory models in toxicology: From the individual to the population

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β-Estradiol antagonizes the inhibitory effects of caffeine in BMMSCs via the ERβ-mediated cAMP-dependent PKA pathway

p-Benzoquinone-induced aggregation and perturbation of structure and chaperone function ofα-crystallin is a causative factor of cigarette smoke-related cataractogenesis

The role of genetic background in susceptibility to chemical warfare nerve agents across rodent and non-human primate models

N-acetyl-l-cysteine and Mn2+ attenuate Cd2+-induced disturbance of the intracellular free calcium homeostasis in cultured cerebellar granule neurons

Applicability of an Integrated Testing Strategy consisting of in silico, in chemico and in vitro assays for evaluating the skin sensitization potencies of isocyanates

The critical role of autophagy in cadmium-induced immunosuppression regulated by endoplasmic reticulum stress-mediated calpain activation in RAW264.7 mouse monocytes

Receptor partial agonism and method to express receptor partial activation with respect to novel Full Logistic Model of mixture toxicology

RNA-Seq revealed ATF3-regulated inflammation induced by silica

Aflatoxin B1 impairs sperm quality and fertilization competence

Molecular mechanisms of nickel induced neurotoxicity and chemoprevention

Protective effect of carvedilol on daunorubicin-induced cardiotoxicity and nephrotoxicity in rats

Metabolic Remodeling Associated With Subchronic Doxorubicin Cardiomyopathy

Susceptibility of Mitochondrial Superoxide Dismutase to Aluminium Induced Oxidative Damage

Methylmercury increases N-methyl-D-aspartate receptors on human SH-SY 5Y neuroblastoma cells leading to neurotoxicity

OpdA, a bacterial organophosphorus hydrolase, prevents lethality in rats after poisoning with highly toxic organophosphorus pesticides

Benzo[a]pyrene induced necrosis in the HepG2 cells via PARP-1 activation and NAD+ depletion

Balancing health benefits and chemical risks associated to dietary habits: RIBEFOOD, a new Internet resource