Terkko Navigator / Toxicology

Increased behavioral and neuronal responses to a hallucinogenic drug after adolescent toluene exposure in mice: Effects of antipsychotic treatment

Impaired mitochondrial function of alveolar macrophages in carbon nanotube-induced chronic pulmonary granulomatous disease

Microphysiological system modeling of ochratoxin A-associated nephrotoxicity

In-vitro toxicity of molybdenum trioxide nanoparticles on human keratinocytes

The protective role of alpha-lipoic acid on the appearance of fibronectin and laminin in renal tubules following diazinon exposure: An experimental immunohistochemical study

The in vitro effects of trimethyltin on the androgen biosynthesis of rat immature Leydig cells

Dual TBK1/IKKε inhibitor amlexanox mitigates palmitic acid-induced hepatotoxicity and lipoapoptosis in vitro

Micromolar concentrations of Zn2+ depress cellular excitability through a blockade of calcium current in rat adrenal slices

Estragole: DNA adduct formation in primary rat hepatocytes and genotoxic potential in HepG2-CYP1A2 cells

A set of six Gene expression biomarkers and their thresholds identify rat liver tumorigens in short-term assays

Effect of P-glycoprotein on the availability of oxime reactivators in the brain

Increased endothelial nitric oxide production after low level lead exposure in rats involves activation of angiotensin II receptors and PI3K/Akt pathway

Methylmercury myotoxicity targets formation of the myotendinous junction

Pharmacological evidence for the involvement of ryanodine receptors in halothane-induced liver injury in mice

Macrophage-derived extracellular vesicles regulate concanavalin A-induced hepatitis by suppressing macrophage cytokine production

Inhibition of TBK1 by amlexanox attenuates paraquat-induced acute lung injury

Articular damages in multi-generational female offspring due to prenatal caffeine exposure correlates with H3K9 deacetylation of TGFβ signaling pathway

Freshly isolated primary human proximal tubule cells as an in vitro model for the detection of renal tubular toxicity

Alpha-lipoic acid effectively attenuates ionizing radiation-mediated testicular dysfunction in rats: Crosstalk of NF-ĸB, TGF-β, and PPAR-ϒ pathways

MicroRNA expression profiling and the role of ALCAM modulating tumor growth and metastasis in benzo[a]pyrene-transformed 16HBE cells

Maternal chlormequat chloride exposure disrupts embryonic growth and produces postnatal adverse effects

Resveratrol ameliorates disorders of mitochondrial biogenesis and mitophagy in rats continuously exposed to benzo(a)pyrene from embryonic development through adolescence

A toxicogenomic approach to assess kidney injury induced by mercuric chloride in rats

Activation of protein kinase R in the manganese-induced apoptosis of PC12 cells

Toxicity of Balb-c mice exposed to recently identified 1,1,2,2-tetrafluoro-2-[1,1,1,2,3,3-hexafluoro-3-(1,1,2,2-tetrafluoroethoxy)propan-2-yl]oxyethane-1-sulfonic acid (PFESA-BP2)

Transcriptional network inference and master regulator analysis of the response to ribosome-inactivating proteins in leukemia cells

Regulation of Hox and ParaHox genes by perfluorochemicals in mouse liver

The Nrf2-mediated defense mechanism associated with HFE genotype limits vulnerability to oxidative stress-induced toxicity

Tert-butylhydroquinone preserve testicular steroidogenesis and spermatogenesis in cisplatin-intoxicated rats by targeting oxidative stress, inflammation and apoptosis

Role of interleukin 1 beta in the regulation of rat intestinal multidrug resistance-associated protein 2 under conditions of experimental endotoxemia

Glycyrrhizin improved autophagy flux via HMGB1-dependent Akt/mTOR signaling pathway to prevent Doxorubicin-induced cardiotoxicity

Maternal nicotine exposure enhances adipose tissue angiogenic activity in offspring: Sex and age differences

Pharmacokinetic profile of Perfluorobutane Sulfonate and activation of hepatic nuclear receptor target genes in mice

Vorinostat is genotoxic and epigenotoxic in the mouse bone marrow cells at the human equivalent doses

Ca2+/CaM/CaMK signaling is involved in cadmium-induced osteoclast differentiation

Evaluation of Mn exposure in the male reproductive system and its relationship with reproductive dysfunction in mice

Mechanism-based identification of plasma metabolites associated with liver toxicity

Nicotine triggers islet β cell senescence to facilitate the progression of type 2 diabetes

Liver toxicity of macrolide antibiotics in zebrafish

Omeprazole attenuates cisplatin-induced kidney injury through suppression of the TLR4/NF-κB/NLRP3 signaling pathway

Altered expression of glutamatergic and GABAergic genes in the valproic acid-induced rat model of autism: A screening test

4-Aminobiphenyl inhibits the DNA homologous recombination repair in human liver cells: The role of miR-630 in downregulating RAD18 and MCM8

Effects of Deltamethrin Acute Exposure on Nav1.6 Channels and Medium Spiny Neurons of the Nucleus Accumbens

Developmental lead (Pb)-induced deficits in redox and bioenergetic status of cerebellar synapses are ameliorated by ascorbate supplementation

Dual mechanisms suppress meloxicam bioactivation relative to sudoxicam

Paracellular permeability changes induced by multi-walled carbon nanotubes in brain endothelial cells and associated roles of hemichannels

Inhibition of ferroptosis attenuates busulfan-induced oligospermia in mice

Wuhan Covid19 data – more questions than answers

Exposure to a Glyphosate-based Herbicide Alters the Expression of Key Regulators of Mammary Gland Development on Pre-pubertal Male Rats

α-Sens: The improved ARE-Nrf2-based sensitization screening assay using normalized transcriptional activity