Table of Contents

Clinical chemistry, molecular diagnostics, and laboratory medicine.
Selection and analytical evaluation of methods- with statistical techniques.
Clinical utility of laboratory tests.
Evidence-based laboratory medicine.
Establishment and use of reference values.
Preanalytical variables and biological variation.
Specimen collection and processing.
Quality management.
Principles of basic techniques and laboratory safety.
Optical techniques.
Electrochemistry and chemical sensors.
Chromatography and extraction.
Mass spectrometry.
Enzyme and rate analyses.
Principles of immunochemical techniques.
Nucleic acid techniques.
Microfabrication and microfluidics and their application to clinical diagnostics.
Automation in the clinical laboratory.
Point-of-care instrumentation.
Amino acids, peptides, and proteins.
Serum enzymes.
Enzymes of the red blood cell.
Tumor markers.
Kidney function tests.
Lipids, lipoproteins, apolipoproteins, and other cardiac risk factors.
Electrolytes and blood gases.
Catecholamines and serotonin.
Vitamins and trace elements.
Hemoglobin, iron, and bilirubin.
The porphyrias and other disorders of porphyrin metabolism.
Therapeutic drugs and their management.
Clinical toxicology.
Toxic metals.
Principles of molecular biology.
Genomes and nucleic acid alterations.
Nucleic acid isolation.
Inherited diseases.
Identity assessment.
Molecular methods in diagnosis and monitoring of infectious diseases.
Hematopoietic malignancies.
Plasma nucleic acids.
Diabetes mellitus.
Cardiac function.
Kidney disease.
Physiology and disorders of water, electrolyte, and acid-base metabolism.
Liver disease.
Gastric, pancreatic, and intestinal function.
Bone and mineral metabolism.
Pituitary function and pathophysiology.
The adrenal cortex.
The thyroid: pathophysiology and thyroid function testing.
Reproductive endocrinology and related disorders.
Pregnancy and its disorders.
Newborn screening and inborn errors of metabolism.
Reference information for the clinical laboratory.