Popular New
- Structure of an inactive conformation of GTP-bound RhoA GTPase9 hStructureRead
- A two-site flexible clamp mechanism for RET-GDNF-GFRα1 assembly reveals both conformational adaptation and strict geometric spacing3 daysStructureRead
- Unveiling the polarity of actin filaments by cryo-electron tomography5 daysStructureRead
- Structures of FHOD1-Nesprin1/2 complexes reveal alternate binding modes for the FH3 domain of formins6 daysStructureRead
- Cryo-EM structure of the EspA filament from enteropathogenic Escherichia coli: revealing the mechanism of effector translocation in the T3SS8 daysStructureRead
- Cryo-EM structure of K+-bound hERG channel complexed with the blocker astemizole8 daysStructureRead
- Using cryo-EM to understand antimycobacterial resistance in the catalase-peroxidase (KatG) from Mycobacterium tuberculosis12 daysStructureRead
- The active DNA-PK holoenzyme occupies a tensed state in a staggered synaptic complex19 daysStructureRead
- A comprehensive binding study illustrates ligand recognition in the periplasmic binding protein PotF20 daysStructureRead
- Structural and functional characterization of the N-terminal acetyltransferase Naa5021 daysStructureRead
- Structural analysis of Mycobacterium tuberculosis M13 metalloprotease Zmp1 open states27 daysStructureRead
- Structure and immune recognition of the porcine epidemic diarrhea virus spike protein27 daysStructureRead
- Allosteric HIV integrase inhibitors promote formation of inactive branched polymers via homomeric carboxy-terminal domain interactions33 daysStructureRead
- A Structural Guide to the Bloom Syndrome Complex34 daysStructureRead
- Clamping, bending, and twisting inter-domain motions in the misfold-recognizing portion of UDP-glucose:glycoprotein glucosyltransferase35 daysStructureRead
- CryoEM map of Pseudomonas aeruginosa PilQ enables structural characterization of TsaP39 daysStructureRead
- Motif orientation matters: structural characterization of TEAD1 recognition of genomic DNA40 daysStructureRead
- Calmodulin binds to Drosophila TRP with an unexpected mode41 daysStructureRead
- Transient association between proteins elicits alteration of dynamics at sites far away from interfaces46 daysStructureRead
- A Conformational Change in the N Terminus of SLC38A9 Signals mTORC1 Activation48 daysStructureRead
- Reprogramming the Specificity of a Protein Interface by Computational and Data-Driven Design48 daysStructureRead
- Allosteric Interference in Oncogenic FLI1 and ERG Transactions by Mithramycins53 daysStructureRead
- Phosphorylation of RIAM by Src Promotes Integrin Activation by Unmasking the PH Domain of RIAM53 daysStructureRead
- Assessing the Structures and Interactions of γD-Crystallin Deamidation Variants53 daysStructureRead
- Cryo-EM Structure of the Prostaglandin E Receptor EP4 Coupled to G Protein55 daysStructureRead
- DStabilize: A Web Resource to Generate Mirror Images of Biomolecules55 daysStructureRead
- Dimeric Structure of the Pseudokinase IRAK3 Suggests an Allosteric Mechanism for Negative Regulation62 daysStructureRead
- A2A Adenosine Receptor Partial Agonism Related to Structural Rearrangements in an Activation Microswitch62 daysStructureRead
- Structure of the Extracellular Region of the Bacterial Type VIIb Secretion System Subunit EsaA62 daysStructureRead
- Structural Basis of CYRI-B Direct Competition with Scar/WAVE Complex for Rac167 daysStructureRead
- Native Mass Spectrometry-Based Screening for Optimal Sample Preparation in Single-Particle Cryo-EM67 daysStructureRead
- Functional and Regulatory Roles of Fold-Switching Proteins76 daysStructureRead
- Malleability of the SARS-CoV-2 3CL Mpro active site cavity facilitates binding of clinical antivirals93 daysStructureRead
- Structural Basis for Toxin Inhibition in the VapXD Toxin-Antitoxin System95 daysStructureRead
- Serial cryoFIB/SEM Reveals Cytoarchitectural Disruptions in Leigh Syndrome Patient Cells95 daysStructureRead
- Amphipathic Motifs Regulate N-BAR Protein Endophilin B1 Auto-inhibition and Drive Membrane Remodeling97 daysStructureRead
- Toward Increased Reliability, Transparency, and Accessibility in Cross-linking Mass Spectrometry102 daysStructureRead
- The Architecture of Inactivated SARS-CoV-2 with Postfusion Spikes Revealed by Cryo-EM and Cryo-ET103 daysStructureRead
- Programmed Trade-offs in Protein Folding Networks104 daysStructureRead
- Structural and Functional Impact of SRP54 Mutations Causing Severe Congenital Neutropenia104 daysStructureRead
- Vaccinia Virus Immunomodulator A46: Destructive Interactions with MAL and MyD88 Shown by Negative-Stain Electron Microscopy109 daysStructureRead
- Ligand Incorporation into Protein Microcrystals for MicroED by On-Grid Soaking116 daysStructureRead
- Biophysical Characterization of Pro-apoptotic BimBH3 Peptides Reveals an Unexpected Capacity for Self-Association125 daysStructureRead
- A “Drug Sweeping” State of the TriABC Triclosan Efflux Pump from Pseudomonas aeruginosa125 daysStructureRead
- Molecular Mechanism of LEDGF/p75 Dimerization130 daysStructureRead
- Negative-Stain Electron Microscopy Reveals Dramatic Structural Rearrangements in Ni-Fe-S-Dependent Carbon Monoxide Dehydrogenase/Acetyl-CoA Synthase131 daysStructureRead
- Cryoelectron-Microscopic Structure of the pKpQIL Conjugative Pili from Carbapenem-Resistant Klebsiella pneumoniae137 daysStructureRead
- Signaling Mechanism of Phytochromes in Solution137 daysStructureRead
- NMR Structure and Dynamics Studies of Yeast Respiratory Supercomplex Factor 2138 daysStructureRead
- IPRO+/−: Computational Protein Design Tool Allowing for Insertions and Deletions151 daysStructureRead
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