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Structure of an inactive conformation of GTP-bound RhoA GTPase

A two-site flexible clamp mechanism for RET-GDNF-GFRα1 assembly reveals both conformational adaptation and strict geometric spacing

Unveiling the polarity of actin filaments by cryo-electron tomography

Structures of FHOD1-Nesprin1/2 complexes reveal alternate binding modes for the FH3 domain of formins

Cryo-EM structure of the EspA filament from enteropathogenic Escherichia coli: revealing the mechanism of effector translocation in the T3SS

Cryo-EM structure of K+-bound hERG channel complexed with the blocker astemizole

Using cryo-EM to understand antimycobacterial resistance in the catalase-peroxidase (KatG) from Mycobacterium tuberculosis

The active DNA-PK holoenzyme occupies a tensed state in a staggered synaptic complex

A comprehensive binding study illustrates ligand recognition in the periplasmic binding protein PotF

Structural and functional characterization of the N-terminal acetyltransferase Naa50

Structural analysis of Mycobacterium tuberculosis M13 metalloprotease Zmp1 open states

Structure and immune recognition of the porcine epidemic diarrhea virus spike protein

Allosteric HIV integrase inhibitors promote formation of inactive branched polymers via homomeric carboxy-terminal domain interactions

A Structural Guide to the Bloom Syndrome Complex

Clamping, bending, and twisting inter-domain motions in the misfold-recognizing portion of UDP-glucose:glycoprotein glucosyltransferase

CryoEM map of Pseudomonas aeruginosa PilQ enables structural characterization of TsaP

Motif orientation matters: structural characterization of TEAD1 recognition of genomic DNA

Calmodulin binds to Drosophila TRP with an unexpected mode

Transient association between proteins elicits alteration of dynamics at sites far away from interfaces

A Conformational Change in the N Terminus of SLC38A9 Signals mTORC1 Activation

Reprogramming the Specificity of a Protein Interface by Computational and Data-Driven Design

Allosteric Interference in Oncogenic FLI1 and ERG Transactions by Mithramycins

Phosphorylation of RIAM by Src Promotes Integrin Activation by Unmasking the PH Domain of RIAM

Assessing the Structures and Interactions of γD-Crystallin Deamidation Variants

Cryo-EM Structure of the Prostaglandin E Receptor EP4 Coupled to G Protein

DStabilize: A Web Resource to Generate Mirror Images of Biomolecules

Dimeric Structure of the Pseudokinase IRAK3 Suggests an Allosteric Mechanism for Negative Regulation

A2A Adenosine Receptor Partial Agonism Related to Structural Rearrangements in an Activation Microswitch

Structure of the Extracellular Region of the Bacterial Type VIIb Secretion System Subunit EsaA

Structural Basis of CYRI-B Direct Competition with Scar/WAVE Complex for Rac1

Native Mass Spectrometry-Based Screening for Optimal Sample Preparation in Single-Particle Cryo-EM

Functional and Regulatory Roles of Fold-Switching Proteins

Malleability of the SARS-CoV-2 3CL Mpro active site cavity facilitates binding of clinical antivirals

Structural Basis for Toxin Inhibition in the VapXD Toxin-Antitoxin System

Serial cryoFIB/SEM Reveals Cytoarchitectural Disruptions in Leigh Syndrome Patient Cells

Amphipathic Motifs Regulate N-BAR Protein Endophilin B1 Auto-inhibition and Drive Membrane Remodeling

Toward Increased Reliability, Transparency, and Accessibility in Cross-linking Mass Spectrometry

The Architecture of Inactivated SARS-CoV-2 with Postfusion Spikes Revealed by Cryo-EM and Cryo-ET

Programmed Trade-offs in Protein Folding Networks

Structural and Functional Impact of SRP54 Mutations Causing Severe Congenital Neutropenia

Vaccinia Virus Immunomodulator A46: Destructive Interactions with MAL and MyD88 Shown by Negative-Stain Electron Microscopy

Ligand Incorporation into Protein Microcrystals for MicroED by On-Grid Soaking

Biophysical Characterization of Pro-apoptotic BimBH3 Peptides Reveals an Unexpected Capacity for Self-Association

A “Drug Sweeping” State of the TriABC Triclosan Efflux Pump from Pseudomonas aeruginosa

Molecular Mechanism of LEDGF/p75 Dimerization

Negative-Stain Electron Microscopy Reveals Dramatic Structural Rearrangements in Ni-Fe-S-Dependent Carbon Monoxide Dehydrogenase/Acetyl-CoA Synthase

Cryoelectron-Microscopic Structure of the pKpQIL Conjugative Pili from Carbapenem-Resistant Klebsiella pneumoniae

Signaling Mechanism of Phytochromes in Solution

NMR Structure and Dynamics Studies of Yeast Respiratory Supercomplex Factor 2

IPRO+/−: Computational Protein Design Tool Allowing for Insertions and Deletions