Table of Contents

Vol-1; Front cover; IFC_Vol. 1; Sleisenger and Fordtran's Gastrointestinal and Liver Disease; Copyright page; Dedication; Contributors; Foreword; Preface; Table of Contents; Video Contents; Abbreviation List; I Biology of the Gastrointestinal Tract; 1 Cellular Growth and Neoplasia; Chapter Outline; Mechanisms of Normal Cell Homeostasis; Cellular Proliferation; Apoptosis; Senescence; Signaling Pathways That Regulate Cellular Growth; Intestinal Tumor Development; Multistep Formation; Clonal Expansion; Cancer Stem Cells; Neoplasia-Associated Genes; Oncogenes; Peptide Growth Factor Oncogenes. Intestinal Epithelial CellsAntigen Trafficking Across the Epithelium; Recognition of Pathogen-Associated Molecular Patterns by Pattern Recognition Receptors; Antigen Presentation in the Gut; Intestinal Mononuclear Cells; Intraepithelial Lymphocytes; Lamina Propria Mononuclear Cells; T Cell Differentiation; Innate Lymphoid Cells; Dendritic Cells; Gut-Associated Lymphoid Tissue-Relevant Chemokines; Key References; References; 3 The Enteric Microbiota; Chapter Outline; Life without Microbes; Primer on Terminology; Methodologies Used to Study the Microbiota; Next-Generation Sequencing; HITChip. MetagenomicsCharacteristics of the Human Gastrointestinal Microbiota; Host-Microbe Spatial Relationships; Host-Microbe Age-Sensitive Relationships; Microbe-Microbe Signaling; Language of Host-Microbe Dialogue; Microbes, Immunity, and Metabolic Health; Microbiota Composition and Disease Associations; Microbes and Drugs; Therapeutic Manipulation of the Microbiota; Intestinal Virome; Future Directions; Key References; References; 4 Gastrointestinal Hormones and Neurotransmitters; Chapter Outline; Hormones and Neurotransmitters; Definitions; Modes of Transmitter Release; Endocrine; Paracrine. Molecular Medicine: Current and Future Approaches in Gastrointestinal OncologyMolecular Diagnostics; Genome-wide Association Studies; Whole Genome Sequencing and Exome Sequencing; Key References; References; 2 Mucosal Immunology and Inflammation*; Chapter Outline; Immune Responses in Gut-Associated Lymphoid Tissue; Controlled/Physiologic Inflammation; Oral Tolerance; Unusual Immunoglobulins of Gut-Associated Lymphoid Tissue; Physiology of Gut-Associated Lymphoid Tissue and the Intestinal Barrier; Functional Anatomy of Gut-Associated Lymphoid Tissue; Peyer's Patches and M Cells. Protein Kinase-Related OncogenesSignal Transduction-Related Oncogenes (Membrane-Associated G Proteins); Nuclear Oncogenes; Tumor Suppressor Genes; Tumor Suppressor Gene Inactivation; Adenomatous Polyposis Coli Gene; TP53 Gene; SMAD4 Gene; DNA Repair Genes; Oncogenic Signaling Pathways; Noncoding RNAs; Epigenetics; Tumor Metabolism; Environmental and Microenvironmental Influences; Chemical Carcinogenesis; Dietary Factors; Microbiome; Inflammation and Cancer; Biological Features of Tumor Metastasis; Epithelial-Mesenchymal Transition; Angiogenesis and Lymphangiogenesis. Now in its 10th edition, Sleisenger and Fordtran's Gastrointestinal and Liver Disease remains your indispensable source for definitive, state-of-the-art answers on every aspect of gastroenterology and hepatology. Overcome your most complex clinical challenges and make optimal use of the newest techniques, technologies, and treatments-with superb guidance from hundreds of world-renowned authorities. Meticulous updates throughout include the latest approaches and improvements in gastrointestinal and liver disease diagnosis and therapy as well as hundreds of images and 35 new procedural videos.