Table of Contents

Epithelial and Nonepithelial Transport and Regulation.
General Principles of Epithelial and Nonepithelial Transport.
Transport Regulation.
Structural and Functional Organization of the Kidney.
Structural Organization.
Functional Organization.
Renal Differentiation and Growth.
Fluid and Electrolyte Regulation and Dysregulation.
Regulation and Disorders of Sodium Chloride Homeostasis.
Regulation and Disorders of Water Homeostasis.
Regulation and Disorders of Potassium Homeostasis.
Regulation and Disorders of Acid-Base Homeostasis.
Regulation and Disorders of Magnesium Homeostasis.
Regulation and Disorders of Calcium Homeostasis.
Regulation and Disorders of Phosphate Homeostasis.
Regulation and Disorders of Organic Solute Homeostasis.
Regulation and Disorders of Proteins and Macromolecules.
Pathophysiology of Renal Disease.
Clinical Presentation of Renal Derangements.
Mechanisms of Renal Injury.
Progression of Renal Disease.
Physiological Considerations in the Management of Renal Disease.
For full table of contents please see the link on the right below the blue bar "Look inside." Epithelial cell structure and polarity.
Mechanisms of ion transport across cell membranes and epithelia.
Renal ion-translocating ATPases: the P-type family.
The mammalian transporter families.
Mechanisms of water transport across cell membranes and epithelia.
Cell volume control.
Solute transport, energy consumption, and production in the kidney.
Electrophysiological analysis of transepithelial transport.
Exchange of fluid solutes across microvascular walls.
External balance of electrolytes acids and alkali.
Principles of cell signaling.
Scaffolding proteins in transport regulation.
The renin-angiotensin system.
Eicosanoids and the kidney.
Kinins and endothelin.
Adensoine in the kidney: physiological roles and mechanisms of biosynthesis.
Extracellular nucleotides and renal function.
Paracrine regulation of renal function by dompamine.
Uroguanylin and guanylin: endocrine link connecting the intestine and kidney for regulation of sodium balance.
Structural organization of the mammalian kidney.
Biophysical basis of glomerular filtration.
Function of the juxtaglomerular apparatus: control of glomerular hemodynamics and renin secretion.
Renal cortical and medullary microcirculations: structure and function.
Molecular and cellular mechanisms of kidney development.
Molecular and cellular mechanisms of glomerular capillary development.
Postnatal renal development.
Renal hyperplasia and hypertrophy: role of cell cycle regulatory proteins.
Epithelial Na+ channels.
Anion channels.
Sodium and chloride transport: proximal nephron.
Sodium chloride transport in the loop of henle, distal convoluted tubule, and collecting duct.
Mineralocorticoid action in the aldosterone-sensitive distal nephron.
Neural control of renal function.
Natriuretic hormones.
Classical and novel hormonal influences on renal tubular transport, and the emerging concept of intracrine regulation. Physiologic principles in the clinical evaluation of electolyte, water, and acid-base disorders.
Pathophysiology of acute kidney injury.
Ischemic renal disease.
Pathophysiology and pathogenesis of diabetic nephropathy.
Renal failure in cirrhosis.
Obstructive uropathy.
Autosomal dominant polycystic kidney disease and inherited cystic diseases.
Immunologic mechanisms of vasculitis.
Renal physiology and disease in pregnancy.
Immune-mediated and other glomerular diseases.
Genetic abnormalities in glomerular function.
Immunological mechanisms of interstitial disease.
Cellular mechanisms of drug nephotoxicity.
Role of glomerular pressure in progression.
Role of proteinuria in progression.
The inflammatory response to ischemic acute renal injury.
The role of dyslipidemias in the progression of chronic kidney disease.
Oxidants in progressive kidney disease.
Chronic kidney disease: pathophysiology and influence of dietary protein.
Management of calcium and bone disease in renal patients.
Hematopoiesis and the kidney.
Electrolyte disturbances in dialysis.
Homeostasis of solute and water by the transplanted kidney.
Disposition and dose requirements of drugs in renal insufficiency. Physiology and pathophysiology of sodium retention and wastage.
Physiology and pathophysiology of diuretic action.
Aquaporin water channels in mammalian kidney.
Thirst and vasopressin.
The urine concentrating mechanism and urea transporters.
Hypernatremic states.
Polyuria and diabetes insipidus.
The molecular biology of renal potassium channels.
Expression, function, and regulation of the H+, K+-ATPase in the kidney.
Extrarenal potassium metabolism.
Regulation of potassium excretion.
Potassium deficiency.
Clinical disorders of hyperkalemia.
The effects of electrolyte disorders on excitable membranes.
Control of intracellular pH.
Sodium-coupled bicarbonate transporters.
The SLC4 anion exchanger gene family.
Cellular mechanisms of renal tubular acidification.
Chemoreceptors, breathing, and pH.
Renal ammonium ion production and excretion.
The acid-base effects of the contemporary Western diet: an evolutionary perspective.
Clinical syndromes of metabolic alkalosis.
Clinical syndromes of metabolic acidosis.
Respiratory alkalosis and acidosis.
Mechanisms and disorders of magnesium metabolism.
Calcium channels.
The calcium-sensing receptor.
Vitamin D.
Renal calcium metabolism.
The hormonal regulation of calcium metabolism.
Disorders of calcium metabolism.
Pathogenesis and treatment of nephrolithiasis --Proximal tubular handling of phosphate: Na/Pi-cotransporters and their regulation.
Clinical disturbances of phosphate homeostasis.
Glucose reabsorption in the kidney: glucosuria: molecular mechanism of Na+/glucose cotransport.
Amino acids, oligopeptides, and hyperaminoacidurias.
Organic anion and cation transporters in renal elimination of drugs.
Renal filtration, transport, and metabolism of albumin and albuminuria. A classic nephrology reference for over 20 years, Seldin & Giebischs The Kidney, is the acknowledged authority on renal physiology and pathophysiology. The fourth edition follows the changed focus of nephrology research to the study of how individual molecules work together to affect cellular and organ function, emphasizing the mechanisms of disease. With over 40 new chapters and over 1000 illustrations, this edition offers the most in-depth discussion anywhere of the physiologic and pathophysiologic processes of renal disease. Comprehensive, authoritative coverage progresses from molecular biology and cell physiology to clinical issues regarding renal function and dysfunction. If you research the development of normal renal function or the mechanisms underlying renal disease, Seldin & Giebischs The Kidney is your number one source for information. Offers the most comprehensive coverage of fluid and electrolyte regulation and dysregulation in 51 completely revised chapters unlike Brenner & Rector's The Kidney which devotes only 7 chapters to this topic. Includes 3 sections, 31 chapters, devoted to regulation and disorders of acid-base homeostasis, and epithelial and nonepithelial transport regulation. Brenner & Rector's only devotes 5 chapters to these topics. Previous three editions edited by Donald Seldin and Gerhard Giebisch, world renowned names in nephrology. The title for the fourth edition has been changed to reflect their considerable work on previous editions and they have also written the forward for this edition. Over 20 million adults over age 20 have chronic kidney disease with the number of people diagnosed doubling each decade making it America's ninth leading cause of death.