Terkko Navigator / Science Translational Medicine

Toward robust mammography-based models for breast cancer risk

Folding DNA to foil the clotting cascade

Better together: Alveolar macrophage and memory T cell cosignaling in ex vivo human lungs

Visualizing antibody production in a human lymph node in a dish

Engineering biopharmaceutical formulations to improve diabetes management

Impaired prenatal motor axon development necessitates early therapeutic intervention in severe SMA

Stereotypic neutralizing VH antibodies against SARS-CoV-2 spike protein receptor binding domain in patients with COVID-19 and healthy individuals

A chimeric antigen receptor with antigen-independent OX40 signaling mediates potent antitumor activity

Whole-exome sequencing reveals germline-mutated small cell lung cancer subtype with favorable response to DNA repair-targeted therapies

Single-cell RNA sequencing reveals SARS-CoV-2 infection dynamics in lungs of African green monkeys

Extracellular vesicles deposit PCNA to rejuvenate aged bone marrow-derived mesenchymal stem cells and slow age-related degeneration

ACE2 abrogates tumor resistance to VEGFR inhibitors suggesting angiotensin-(1-7) as a therapy for clear cell renal cell carcinoma

Characterization of ascites- and tumor-infiltrating {gamma}{delta} T cells reveals distinct repertoires and a beneficial role in ovarian cancer

The cortical origin and initial spread of medial temporal tauopathy in Alzheimers disease assessed with positron emission tomography

Does protein aggregation drive postmitotic tissue degeneration?

Enhanced SARS-CoV-2 neutralization by dimeric IgA

IgA dominates the early neutralizing antibody response to SARS-CoV-2

Could COVID-19 eliminate the alarm clock?

The benefits of memory growing granular

Unconventional interleukin-1{beta} release suppresses antitumor immunity

Diet-induced obesity promotes infection by impairment of the innate antimicrobial defense function of dermal adipocyte progenitors

Small-molecule screen reveals synergy of cell cycle checkpoint kinase inhibitors with DNA-damaging chemotherapies in medulloblastoma

Spatiotemporal single-cell profiling reveals that invasive and tissue-resident memory donor CD8+ T cells drive gastrointestinal acute graft-versus-host disease

The microbiota in pneumonia: From protection to predisposition

Kidney disease genetic risk variants alter lysosomal beta-mannosidase (MANBA) expression and disease severity

In aged hosts, T cells turn traitorous

A QuICR test to diagnose Parkinsons disease

Probing the entire vascular system

The intratumoral CXCR3 chemokine system is predictive of chemotherapy response in human bladder cancer

Targeting cartilage EGFR pathway for osteoarthritis treatment

Measurement of leukocyte trafficking kinetics in macaques by serial intravascular staining

Enhanced drug delivery to the reproductive tract using nanomedicine reveals therapeutic options for prevention of preterm birth

Heightened resistance to host type 1 interferons characterizes HIV-1 at transmission and after antiretroviral therapy interruption

CRISPR cuts disease course short in blood disorders

Unraveling the mysteries of microsatellite instability

A protein sandwich enables real-time in vivo biomarker measurement

A genome-wide CRISPR-based screen identifies KAT7 as a driver of cellular senescence

Bacteria-specific phototoxic reactions triggered by blue light and phytochemical carvacrol

Delivery of single-domain antibodies into neurons using a chimeric toxin-based platform is therapeutic in mouse models of botulism

Mitochondrial metabolic reprogramming controls the induction of immunogenic cell death and efficacy of chemotherapy in bladder cancer

Reversible ON- and OFF-switch chimeric antigen receptors controlled by lenalidomide

Necrotizing enterocolitis induces T lymphocyte-mediated injury in the developing mammalian brain

Neuronal delivery of antibodies has therapeutic effects in animal models of botulism

Quarterly picks from the editors

Mutant huntingtin and neurofilament light have distinct longitudinal dynamics in Huntingtons disease

Chi3l1/YKL-40 is controlled by the astrocyte circadian clock and regulates neuroinflammation and Alzheimers disease pathogenesis

Lung transplantation for patients with severe COVID-19

Wireless sensors for continuous, multimodal measurements at the skin interface with lower limb prostheses

Targeting therapy-resistant prostate cancer via a direct inhibitor of the human heat shock transcription factor 1

Plasma exosomal miR-375-3p regulates mitochondria-dependent keratinocyte apoptosis by targeting XIAP in severe drug-induced skin reactions