Terkko Navigator / Science Translational Medicine

Glycolysis links reciprocal activation of myeloid cells and endothelial cells in the retinal angiogenic niche

Confetti illuminates the cryptic way calorie restriction protects from cancer

Chrono-immunization with BCG: It is about "time"!

Not all fibroblasts are equal in cancer

Estrogen receptor {alpha} controls metabolism in white and brown adipocytes by regulating Polg1 and mitochondrial remodeling

Colorectal cancer residual disease at maximal response to EGFR blockade displays a druggable Paneth cell-like phenotype

An Alphavirus-derived replicon RNA vaccine induces SARS-CoV-2 neutralizing antibody and T cell responses in mice and nonhuman primates

CytoPAN--Portable cellular analyses for rapid point-of-care cancer diagnosis

Using influenza surveillance networks to estimate state-specific prevalence of SARS-CoV-2 in the United States

Scientific considerations for global drug development

The safety and clinical effects of administering a multiantigen-targeted T cell therapy to patients with multiple myeloma

Activation of NRF2 ameliorates oxidative stress and cystogenesis in autosomal dominant polycystic kidney disease

Stimulated bone growth and metal-infused skeletons: From comic books to commonplace

Living swine to maintain donor organs

Understanding sex-related differences in immune responses

Cellular senescence impairs the reversibility of pulmonary arterial hypertension

Clinical trial in a dish using iPSCs shows lovastatin improves endothelial dysfunction and cellular cross-talk in LMNA cardiomyopathy

Apoptosis of hematopoietic progenitor-derived adipose tissue-resident macrophages contributes to insulin resistance after myocardial infarction

siRNA nanoparticles targeting CaMKII{gamma} in lesional macrophages improve atherosclerotic plaque stability in mice

Could gut flora cycles be key to treating diabetes?

Loss of TET2 boosts cell fitness

Brain structural changes in sync with the cycle

Mapping functional humoral correlates of protection against malaria challenge following RTS,S/AS01 vaccination

Multichannel optogenetic stimulation of the auditory pathway using microfabricated LED cochlear implants in rodents

Disrupting the platelet internal membrane via PI3KC2{alpha} inhibition impairs thrombosis independently of canonical platelet activation

Mapping the tumor frontline

Plasma proteins have a ticket to ride the blood-brain barrier

Care packages for the bone marrow

STING differentially regulates experimental GVHD mediated by CD8 versus CD4 T cell subsets

Two-miRNA-based finger-stick assay for estimation of absorbed ionizing radiation dose

High-loading G{alpha}13-binding EXE peptide nanoparticles prevent thrombosis and protect mice from cardiac ischemia/reperfusion injury

Dynamic changes in glioma macrophage populations after radiotherapy reveal CSF-1R inhibition as a strategy to overcome resistance

Ethical challenges for pediatric liver organoid transplantation

Gut microbiota dysbiosis and altered tryptophan catabolism contribute to autoimmunity in lupus-susceptible mice

Clearing the path for gene therapy

Do dendritic cells hold the key to regulating cancer antitumor immunity?

Paving the path to in-patient printing

Staphylococcus Agr virulence is critical for epidermal colonization and associates with atopic dermatitis development

Cyclin-dependent-like kinase 5 is required for pain signaling in human sensory neurons and mouse models

An extracorporeal bioartificial liver embedded with 3D-layered human liver progenitor-like cells relieves acute liver failure in pigs

PRMT5 control of cGAS/STING and NLRC5 pathways defines melanoma response to antitumor immunity

Circulating transcripts in maternal blood reflect a molecular signature of early-onset preeclampsia

Intestinal goblet cells protect against GVHD after allogeneic stem cell transplantation via Lypd8

Cellular senolytics

Less is more for adoptive immunotherapy?

Nanosponges intercept coronavirus infection

Antibody signature induced by SARS-CoV-2 spike protein immunogens in rabbits

An ultrafast insulin formulation enabled by high-throughput screening of engineered polymeric excipients

Enhanced efficacy of mesothelin-targeted immunotoxin LMB-100 and anti-PD-1 antibody in patients with mesothelioma and mouse tumor models

Quarterly picks from the editors