Terkko Navigator / Science Translational Medicine

Engineered probiotics for local tumor delivery of checkpoint blockade nanobodies

The tick tock of toxicity

Bilirubin enhances the activity of ASIC channels to exacerbate neurotoxicity in neonatal hyperbilirubinemia in mice

JAK inhibition increases bone mass in steady-state conditions and ameliorates pathological bone loss by stimulating osteoblast function

Mannose receptor (CD206) activation in tumor-associated macrophages enhances adaptive and innate antitumor immune responses

Two drugs converged in a pancreatic {beta} cell

Elevated plasma {beta}-hydroxybutyrate predicts adverse outcomes and disease progression in patients with arrhythmogenic cardiomyopathy

Maybe not an overreaction

A spring-like renewal in the lungs

GLP-1 receptor agonists synergize with DYRK1A inhibitors to potentiate functional human {beta} cell regeneration

Distinct immune phenotypes in infants developing asthma during childhood

APOE4 exacerbates {alpha}-synuclein pathology and related toxicity independent of amyloid

APOE genotype regulates pathology and disease progression in synucleinopathy

Osteoclast-mediated bone resorption is controlled by a compensatory network of secreted and membrane-tethered metalloproteinases

The prolactin receptor long isoform regulates nociceptor sensitization and opioid-induced hyperalgesia selectively in females

Livening up pertussis vaccine development

Undressing drug reactions, one cell at a time

Lets switch on AAV!

Immune system development varies according to age, location, and anemia in African children

Immune correlates of tuberculosis disease and risk translate across species

Airway macrophages reveal their origins

Unfolding the mystery of UPR in astrocytes

Immunomodulation in the front, bone-binding in the back

Mapping global variation in dengue transmission intensity

Preclinical efficacy of the GPER-selective agonist G-1 in mouse models of obesity and diabetes

Different human resting memory CD4+ T cell subsets show similar low inducibility of latent HIV-1 proviruses

A dual apolipoprotein C-II mimetic-apolipoprotein C-III antagonist peptide lowers plasma triglycerides

Mixed chimerism and acceptance of kidney transplants after immunosuppressive drug withdrawal

Gene therapy delivering a paraoxonase 1 variant offers long-term prophylactic protection against nerve agents in mice

Deep phenotyping during pregnancy for predictive and preventive medicine

The IDH-TAU-EGFR triad defines the neovascular landscape of diffuse gliomas

Pan-viral protection against arboviruses by activating skin macrophages at the inoculation site

Hitting a double to treat cancer

Neurodevelopment and risk for ADHD and depression

Angling for a bug-inspired method of coating therapeutics onto microneedles

PI4KIII{beta} is a therapeutic target in chromosome 1q-amplified lung adenocarcinoma

Long-gap peripheral nerve repair through sustained release of a neurotrophic factor in nonhuman primates

Cerebellar oscillations driven by synaptic pruning deficits of cerebellar climbing fibers contribute to tremor pathophysiology

Weighing in on asthma

The "cancer flu shot"?

Organoid optimization: Engineering a better cell therapy to treat type 1 diabetes

Human umbilical cord perivascular cells improve human pancreatic islet transplant function by increasing vascularization

Engraftment of rare, pathogenic donor hematopoietic mutations in unrelated hematopoietic stem cell transplantation

{beta}-amyloid redirects norepinephrine signaling to activate the pathogenic GSK3{beta}/tau cascade

Intratumoral expression of IL-7 and IL-12 using an oncolytic virus increases systemic sensitivity to immune checkpoint blockade

Stromal cell protein kinase C-{beta} inhibition enhances chemosensitivity in B cell malignancies and overcomes drug resistance

Bystanders get in the game

Microglial sex affects Alzheimers disease

A potential gut punch to gastric cancer

GDNF rescues the fate of neural progenitor grafts by attenuating Notch signals in the injured spinal cord in rodents