Table of Contents

Properties that Impact Sample Preparation and Extraction of Pharmaceutical Dosage Forms.
Sampling Considerations.
Agitation and Particle Size Reduction Techniques.
Liquid-Liquid and Solid-Phase Extraction Techniques.
Extraction Techniques Leveraging Elevated Temperature and Pressure.
Addressing Drug-Excipient Interactions.
Sample Preparation for Solid Oral Dosage Forms.
Sample Preparation for Select Non Solid Dosage Forms.
Post-Extraction Considerations.
Sample Preparation Method Validation.
Application of Quality by Design (QbD) Principles for Sample Preparation.
Automation and Sample Preparation.
A Systematic Approach for Investigating Aberrant Potency Values.
Green Chemistry Considerations for Sample Preparation.
No Sample Preparation. This book is a resource for analysts in developing and troubleshooting sample preparation methods, which are critical activities in providing accurate data throughout the lifecycle of a drug product. Multiple examples and case studies are presented.