Table of Contents

Prologue: Signal Transduction, origins and ancestors.
First messengers.
Receptors.
GTP-binding proteins and signal transduction.
Effector enzymes coupled to GTP binding proteins: adenylyl cyclase and phospholipase C.
The regulation of visual transduction and olfaction.
Intracellular calcium.
Calcium effectors.
Phosphorylation and dephosphorylation: protein kinases A and C.
Nuclear receptors.
Growth Factors: Setting the framework.
Signalling pathways operated by receptor protein tyrosine kinases.
Signal transduction to and from adhesion molecules.
Adhesion molecules in the regulation of cell differentiation: Mainly about Wnt.
Activation of the innate immune system: the Toll-like receptor 4 and Signalling through Ubiquitylation.
Traffic of white blood cells.
Tyrosine protein kinases and adaptive immunity : TCR, BCR, soluble tyrosine kinases and NFAT.
Phosphoinositide 3-kinases, protein kinase B and signalling through the insulin receptor.
Protein Kinase C revisited.
Signalling through receptor serine/threonine kinases.
Protein dephosphorylation and protein phosphorylation.
Notch.
Targeting transduction pathways for research and medical intervention.
Protein domains and signal transduction.