Terkko Navigator / Proceedings of the National Academy of Sciences of the United States of America

The hygiene hypothesis, the COVID pandemic, and consequences for the human microbiome [Microbiology]

Coronavirus replication-transcription complex: Vital and selective NMPylation of a conserved site in nsp9 by the NiRAN-RdRp subunit [Microbiology]

Water emissions put a damper on the coal-to-gas transition [Earth, Atmospheric, and Planetary Sciences]

Tornado-inspired acoustic vortex tweezer for trapping and manipulating microbubbles [Medical Sciences]

A cancer in hybrids [Genetics]

R-spondin substitutes for neuronal input for taste cell regeneration in adult mice [Neuroscience]

Control of septum thickness by the curvature of SepF polymers [Microbiology]

A rate threshold mechanism regulates MAPK stress signaling and survival [Systems Biology]

Real-time observation of Cas9 postcatalytic domain motions [Biophysics and Computational Biology]

Convective isolation of Hadean mantle reservoirs through Archean time [Environmental Sciences]

Efficient CRISPR-mediated base editing in Agrobacterium spp. [Applied Biological Sciences]

Reston virus causes severe respiratory disease in young domestic pigs [Medical Sciences]

Mechanisms and plasticity of chemogenically induced interneuronal suppression of principal cells [Neuroscience]

Molecular mechanism of the repressive phase of the mammalian circadian clock [Biochemistry]

Knockout of the HMG domain of the porcine SRY gene causes sex reversal in gene-edited pigs [Genetics]

Cerebellar Purkinje cells can differentially modulate coherence between sensory and motor cortex depending on region and behavior [Neuroscience]

Sound-induced motion in chimpanzees does not imply shared ancestry for music or dance [Social Sciences]

Additional observations regarding glyphosate-based herbicides and developmental toxicity [Biological Sciences]

Reply to Reeves and Dunn: Risk for autism in offspring after maternal glyphosate exposure [Biological Sciences]

Reply to Bertolo et al.: Rhythmic swaying in chimpanzees has implications for understanding the biological roots of music and dance [Social Sciences]

Sarcomeres regulate murine cardiomyocyte maturation through MRTF-SRF signaling [Developmental Biology]

Forward-looking serial intervals correctly link epidemic growth to reproduction numbers [Population Biology]

DeepTracer for fast de novo cryo-EM protein structure modeling and special studies on CoV-related complexes [Biophysics and Computational Biology]

Structure of SARS-CoV-2 ORF8, a rapidly evolving immune evasion protein [Biophysics and Computational Biology]

A data-driven approach to identify risk profiles and protective drugs in COVID-19 [Statistics]

Environmental noise degrades hippocampus-related learning and memory [Neuroscience]

Binding of cardiotonic steroids to Na+,K+-ATPase in the E2P state [Biochemistry]

Targeting transcriptional regulation of SARS-CoV-2 entry factors ACE2 and TMPRSS2 [Medical Sciences]

Mobility restrictions are more than transient reduction of travel activities [Commentaries]

Opinion: We need to improve the welfare of life science trainees [Economic Sciences]

Correction to Supporting Information for Kim and Kim, Prediction of inherited genomic susceptibility to 20 common cancer types by a supervised machine-learning method [SI Correction]

In This Issue [This Week in PNAS]

Lower Paleolithic bone handaxes and chopsticks: Tools and symbols? [Biological Sciences]

Reply to Barkai: Implications of the Konso bone handaxe [Biological Sciences]

Does tocilizumab have a magical therapeutic effect on COVID-19 patients without obvious adverse reactions? [Biological Sciences]

Reply to Wang et al.: Tocilizumab treatment should be used in a timely manner, at suitable dose, and in suitable patients [Biological Sciences]

QnAs with Catherine L. Kling [QnAs]

Profile of Se-Jin Lee [Profiles]

A Golgi-associated lipid kinase controls peripheral nerve myelination [Cell Biology]

A MASCOT for mosaic analysis [Genetics]

Angiosperms versus gymnosperms in the Cretaceous [Evolution]

Post-2020 biodiversity targets need to embrace climate change [Sustainability Science]

Development of cyclic peptides with potent in vivo osteogenic activity through RaPID-based affinity maturation [Applied Biological Sciences]

Local conformal autoencoder for standardized data coordinates [Applied Mathematics]

Moth wings are acoustic metamaterials [Applied Mathematics]

Global analysis of more than 50,000 SARS-CoV-2 genomes reveals epistasis between eight viral genes [Applied Physical Sciences]

The Arg/N-degron pathway targets transcription factors and regulates specific genes [Biochemistry]

Mutation-oriented profiling of autoinhibitory kinase conformations predicts RAF inhibitor efficacies [Biochemistry]

The SERCA residue Glu340 mediates interdomain communication that guides Ca2+ transport [Biochemistry]

Hsp40 proteins phase separate to chaperone the assembly and maintenance of membraneless organelles [Biochemistry]