Terkko Navigator / Proceedings of the National Academy of Sciences of the United States of America

In This Issue [This Week in PNAS]

On the multibin logarithmic score used in the FluSight competitions [Biological Sciences]

Reply to Bracher: Scoring probabilistic forecasts to maximize public health interpretability [Biological Sciences]

Reward prediction tells us less than expected about musical pleasure [Biological Sciences]

Reply to de Fleurian et al.: Toward a fuller understanding of reward prediction errors and their role in musical pleasure [Biological Sciences]

Messenger RNA therapy as an option for treating metabolic disorders [Medical Sciences]

Forgetting memories through distinct actin remodeling mechanisms [Neuroscience]

Wildfire prevention through prophylactic treatment of high-risk landscapes using viscoelastic retardant fluids [Applied Physical Sciences]

A general constitutive model for dense, fine-particle suspensions validated in many geometries [Applied Physical Sciences]

Reviving rare chicken breeds using genetically engineered sterility in surrogate host birds [Agricultural Sciences]

Xanthomonas translucens commandeers the host rate-limiting step in ABA biosynthesis for disease susceptibility [Agricultural Sciences]

Francisella novicida Cas9 interrogates genomic DNA with very high specificity and can be used for mammalian genome editing [Applied Biological Sciences]

Rationally engineered Staphylococcus aureus Cas9 nucleases with high genome-wide specificity [Biochemistry]

A CTG repeat-selective chemical screen identifies microtubule inhibitors as selective modulators of toxic CUG RNA levels [Biochemistry]

Mapping low-affinity/high-specificity peptide-protein interactions using ligand-footprinting mass spectrometry [Biochemistry]

Overcoming insecticide resistance through computational inhibitor design [Biochemistry]

Capsid expansion of bacteriophage T5 revealed by high resolution cryoelectron microscopy [Biophysics and Computational Biology]

Empirical measures of mutational effects define neutral models of regulatory evolution in Saccharomyces cerevisiae [Evolution]

A functional enrichment test for molecular convergent evolution finds a clear protein-coding signal in echolocating bats and whales [Evolution]

Allele-specific nonstationarity in evolution of influenza A virus surface proteins [Evolution]

Extrapituitary prolactin promotes generation of Eomes-positive helper T cells mediating neuroinflammation [Immunology and Inflammation]

ROR{alpha} is crucial for attenuated inflammatory response to maintain intestinal homeostasis [Immunology and Inflammation]

Lipid nanoparticle-targeted mRNA therapy as a treatment for the inherited metabolic liver disorder arginase deficiency [Medical Sciences]

Photopotentiation of the GABAA receptor with caged diazepam [Neuroscience]

Gradients of structure-function tethering across neocortex [Neuroscience]

Muscle acetylcholine receptor conversion into chloride conductance at positive potentials by a single mutation [Neuroscience]

KCNQ5 activation is a unifying molecular mechanism shared by genetically and culturally diverse botanical hypotensive folk medicines [Pharmacology]

Interaction between VPS35 and RABG3f is necessary as a checkpoint to control fusion of late compartments with the vacuole [Plant Biology]

Contemporary evolution of maize landraces and their wild relatives influenced by gene flow with modern maize varieties [Population Biology]

Neural dynamics of semantic composition [Psychological and Cognitive Sciences]

Engineering the stereoisomeric structure of seed oil to mimic human milk fat [Applied Biological Sciences]

A large-scale study reveals 24-h operational rhythms in hospital treatment [Applied Biological Sciences]

Rotational symmetry of the structured Chip/LDB-SSDP core module of the Wnt enhanceosome [Biochemistry]

Structural basis of light-induced redox regulation in the Calvin-Benson cycle in cyanobacteria [Biochemistry]

How internal cavities destabilize a protein [Biophysics and Computational Biology]

Structure of a C2S2M2N2-type PSII-LHCII supercomplex from the green alga Chlamydomonas reinhardtii [Biophysics and Computational Biology]

Intact carbonic acid is a viable protonating agent for biological bases [Chemistry]

Waterproof molecular monolayers stabilize 2D materials [Chemistry]

The binuclear cluster of [FeFe] hydrogenase is formed with sulfur donated by cysteine of an [Fe(Cys)(CO)2(CN)] organometallic precursor [Chemistry]

Theory and simulations for RNA folding in mixtures of monovalent and divalent cations [Chemistry]

A triple drug combination targeting components of the nutrient-sensing network maximizes longevity [Developmental Biology]

Paternal knockout of Slc38a4/SNAT4 causes placental hypoplasia associated with intrauterine growth restriction in mice [Developmental Biology]

{beta}-Catenin is required for radial cell patterning and identity in the developing mouse cochlea [Developmental Biology]

The conflict between adaptation and dispersal for maintaining biodiversity in changing environments [Ecology]

Declining CO2 price paths [Economic Sciences]

Shape-shifting structured lattices via multimaterial 4D printing [Engineering]

Multibioinspired slippery surfaces with wettable bump arrays for droplets pumping [Engineering]

Core Concept: Blockchain offers applications well beyond Bitcoin but faces its own limitations [Environmental Sciences]

Rapid increase in Asian bottles in the South Atlantic Ocean indicates major debris inputs from ships [Environmental Sciences]

On the feasibility of saltational evolution [Evolution]