Terkko Navigator / Proceedings of the National Academy of Sciences of the United States of America

In This Issue [This Week in PNAS]

Temperature impact on GDP growth is overestimated [Social Sciences]

Reply to Rosen: Temperature-growth relationship is robust [Social Sciences]

Familial hyperkalemia and hypertension and a hypothesis to explain proximal renal tubular acidosis [Biological Sciences]

Reply to Farfel et al.: Is enhanced chloride reabsorption in proximal tubule a possible mechanism of metabolic acidosis in PHAII? [Biological Sciences]

QnAs with Elizabeth Ainsworth [QnAs]

Water and methane stay together at extreme pressures [Chemistry]

Origin of programmed cell death from antiviral defense? [Genetics]

Universal amplification-free molecular diagnostics by billion-fold hierarchical nanofluidic concentration [Engineering]

Infants expect leaders to right wrongs [Psychological and Cognitive Sciences]

Selective incorporation of proteinaceous over nonproteinaceous cationic amino acids in model prebiotic oligomerization reactions [Biochemistry]

Two PKA RI{alpha} holoenzyme states define ATP as an isoform-specific orthosteric inhibitor that competes with the allosteric activator, cAMP [Biochemistry]

In vitro 0N4R tau fibrils contain a monomorphic {beta}-sheet core enclosed by dynamically heterogeneous fuzzy coat segments [Biophysics and Computational Biology]

High-speed AFM reveals subsecond dynamics of cardiac thin filaments upon Ca2+ activation and heavy meromyosin binding [Biophysics and Computational Biology]

Structural basis for GPCR-independent activation of heterotrimeric Gi proteins [Biophysics and Computational Biology]

Regulation of CCL2 expression in human vascular endothelial cells by a neighboring divergently transcribed long noncoding RNA [Cell Biology]

Disruption of IRE1{alpha} through its kinase domain attenuates multiple myeloma [Cell Biology]

Meiotic viral attenuation through an ancestral apoptotic pathway [Genetics]

A deep intronic splice mutation of STAT3 underlies hyper IgE syndrome by negative dominance [Genetics]

TMEM203 is a binding partner and regulator of STING-mediated inflammatory signaling in macrophages [Immunology and Inflammation]

SLAMF9 regulates pDC homeostasis and function in health and disease [Immunology and Inflammation]

Autophagy genes in myeloid cells counteract IFN{gamma}-induced TNF-mediated cell death and fatal TNF-induced shock [Immunology and Inflammation]

How Kaposi’s sarcoma-associated herpesvirus stably transforms peripheral B cells towards lymphomagenesis [Medical Sciences]

Kinome profiling of non-Hodgkin lymphoma identifies Tyro3 as a therapeutic target in primary effusion lymphoma [Microbiology]

Leptin signaling impairs macrophage defenses against Salmonella Typhimurium [Microbiology]

Dynamic colocalization of 2 simultaneously active VSG expression sites within a single expression-site body in Trypanosoma brucei [Microbiology]

Parvalbumin interneuron in the ventral hippocampus functions as a discriminator in social memory [Neuroscience]

Mutant huntingtin disrupts mitochondrial proteostasis by interacting with TIM23 [Neuroscience]

In vivo imaging reveals transient microglia recruitment and functional recovery of photoreceptor signaling after injury [Neuroscience]

Parietal low beta rhythm provides a dynamical substrate for a working memory buffer [Neuroscience]

Blastocyst activation engenders transcriptome reprogram affecting X-chromosome reactivation and inflammatory trigger of implantation [Physiology]

A thylakoid membrane-bound and redox-active rubredoxin (RBD1) functions in de novo assembly and repair of photosystem II [Plant Biology]

Histone acetylation recruits the SWR1 complex to regulate active DNA demethylation in Arabidopsis [Plant Biology]

Functional selection of protease inhibitory antibodies [Applied Biological Sciences]

The role of shape-dependent flight stability in the origin of oriented meteorites [Applied Physical Sciences]

Anisotropic spin-orbit torque generation in epitaxial SrIrO3 by symmetry design [Applied Physical Sciences]

Phase separation and clustering of an ABC transporter in Mycobacterium tuberculosis [Biochemistry]

Phosphatidylserine flipping by the P4-ATPase ATP8A2 is electrogenic [Biochemistry]

Mechanical and kinetic factors drive sorting of F-actin cross-linkers on bundles [Biophysics and Computational Biology]

UvrD helicase activation by MutL involves rotation of its 2B subdomain [Biophysics and Computational Biology]

Protein stability engineering insights revealed by domain-wide comprehensive mutagenesis [Biophysics and Computational Biology]

Frustration and folding of a TIM barrel protein [Biophysics and Computational Biology]

Aging of spermatogonial stem cells by Jnk-mediated glycolysis activation [Cell Biology]

Excitation energy-dependent photocurrent switching in a single-molecule photodiode [Chemistry]

Observation of methane filled hexagonal ice stable up to 150 GPa [Chemistry]

Energy conversion via metal nanolayers [Chemistry]

Hox genes limit germ cell formation in the short germ insect Gryllus bimaculatus [Developmental Biology]

Opinion: To advance sustainable stewardship, we must document not only biodiversity but geodiversity [Earth, Atmospheric, and Planetary Sciences]

Core Concept: Seismic tomography uses earthquake waves to probe the inner Earth [Earth, Atmospheric, and Planetary Sciences]

African biomass burning is a substantial source of phosphorus deposition to the Amazon, Tropical Atlantic Ocean, and Southern Ocean [Earth, Atmospheric, and Planetary Sciences]