Table of Contents

Modelling in the pharmaceutical industry.
Physiologically-based modelling.
A review of pharmacokinetic principles.
Physiological model for absorption.
Physiological model for distribution.
Physiological models for drug metabolism and excretion.
Generic whole-body physiologically-based pharmacokinetic modelling.
Variability, uncertainty and sensitivity analysis.
Evaluation of drug-drug interaction risk with pbpk models.
PBPK of biotherapeutics.
Data integration and sensitivity analysis.
Hypothesis generation and pharmacokinetic predictions.
Integration of PBPK and pharmacodynamics.
PBPK modelling of populations.
PBPK models along the drug discovery and development value chain.