Table of Contents

part I. Introduction to tumor biology from a biophysical point of view.
1. Initiation of a neoplasm or tumor.
1.1. Initiation of a neoplasm, tumor growth and neoangiogenesis.
1.2. Malignant progression of cancer (metastasis).
1.3. Hallmarks of cancer.
1.4. The impact of the mechanical properties of cancer cells on their migration 2. Inflammation and cancer.
2.1. Inflammation : acute and chronic.
2.2. The dual relationship between inflammation and cancer part II. The role of the mechanical properties of cancer cells in cellular invasion. 3. Cellular stiffness and deformability.
3.1. How can cellular stiffness and the deformability of cells be measured?.
3.2. Magnetic tweezers.
3.3. Optical cell stretcher.
3.4. Optical tweezers.
3.5. Microfluidic filtration and mechanical deformability.
3.6. Real-time deformation cytometry 4. Cell-cell and cell-matrix adhesion strength, local cell stiffness and forces.
4.1. Atomic force microscopy.
4.2. Traction forces.
4.3. Lipid drops as stress sensors.
4.4. Dual micropipette aspiration (DPA).
4.5. Förster resonance energy transfer (FRET)-based molecular tension sensors 5. Cell surface tension, the mobility of cell surface receptors and their location in specific regions.
5.1. Surface tension.
5.2. The mobility of surface receptors.
5.3. Specific membrane regions as a location for surface receptors.
5.4. Role of the cortex confinement on membrane diffusion 6. Cytoskeletal remodeling dynamics.
6.1. Cytoskeletal remodeling dynamics within unperturbed cells.
6.2. Cytoskeletal remodeling dynamics upon mechanical stretching.
6.3. Dynamic cell-level responses derive from local physical cues.
6.4. Cytoskeletal dynamics in 3D differ from those observed in 2D.
6.5. Nano-scale particle tracking.
6.6. FRAP 8. Intermediate filaments and nuclear deformability during matrix invasion.
8.1. Structure and assembly of intermediate filaments.
8.2. Involvement of intermediate filaments in vesicular trafficking.
8.3. Intermediate filaments play a crucial role in cellular mechanical properties and cellular motility.
8.4. Viscoelasticity of purified intermediate filaments in vitro.
8.5. Functional role of intermediate filaments in mechanotransduction processes.
8.6. The role of intermediate and actin filament interactions.
8.7. The role of vimentin as a promotor of cell migration during cancer progression.
8.8. The impact of keratins 8/18 on epithelial cell migration.
8.9. Interaction between filamin A and vimentin in cellular motility.
8.10. The role of nuclear intermediate filaments in cell invasion.
8.11. The role of cell division in cellular motility. In order to increase the healing opportunities of cancer, it is important to impair the dissemination and the spreading of cancer cells from the initial tumor and the formation of metastases in other organs or tissues of the human body. The underlying physical principles of these oncological processes are a major constituent of the research field highlighted in Physics of Cancer. This revised second edition is improved linguistically with multiple increases of the number of figures and the inclusion of several novel chapters such as actin filaments during matrix invasion, microtubuli during migration and matrix invasion, nuclear deformability during migration and matrix invasion, and the active role of the tumor stroma in regulating cell invasion