Table of Contents

part IV. The effect of microtubules and the mechanical properties of the nucleus on matrix invasion.
9. Microtubules during migration and matrix invasion.
9.1. The structure and assembly of microtubules.
9.2. The assembly of the mitotic spindle during cell division.
9.3. Microtubules and cell motility.
9.4. Effect of microtubules on cell mechanical properties.
9.5. The interactions of microtubules with actin filaments.
9.6. Effect of the microtubule-actin interaction on the mechanical properties of cells.
9.7. The impact of microtubule alterations on diseases such as cancer metastasis 10. Nuclear deformability during migration and matrix invasion.
10.1. The physical role of the nucleus in cell migration.
10.2. Mechanical properties of the nucleus.
10.3. Nucleus-cytoskeleton-extracellular matrix connections.
10.4. Mechanosensitivity and mechanotransduction.
10.5. Nuclear positioning and cell polarization in cell migration.
10.6. Nucleus-cytoskeleton connection dependent cell migration.
10.7. Cell squeezing through constrictions.
10.8. Models of the nucleus during cell migration.
10.9. Nucleoskeleton.
10.10. Cytoskeletal forces pulling or pushing on the nucleus.
10.11. Physical compartmentalization by the nucleus.
10.12. Biological consequences of nuclear deformation during 3D cell migration.
10.13. Nuclear mechanotransduction.
10.14. Nuclear envelope rupture and repair during cancer cell migration part V. The impact of the tumor microenvironment on cellular invasion.
11. The mechanical and structural properties of the microenvironment.
11.1. Why is the extracellular matrix of connective tissue crucial for the invasion of cancer cells?.
11.2. 3D collagen matrices partly mimic the natural extracellular matrix scaffold.
11.3. Pore size.
11.4. Matrix stiffness.
11.5. Matrix composition.
11.6. The impact of fiber thickness, connection points and polymerization dynamics on cancer cell invasion.
11.7. The role of a matrix stiffness gradient in cancer cell invasion 12. The impact of cells and substances within the extracellular matrix tissue on mechanical properties and cell invasion.
12.1. The impact of tumor-associated fibroblasts on matrix mechanical properties.
12.2. Cancer-associated fibroblasts align fibronectin in the matrix to enhance cancer cell migration.
12.3. The role of substances and growth factors within the extracellular matrix for cancer cell mechanical properties.
12.4. Mechanical properties of extracellular matrix fiber networks using magnetic twisting cytometry 13. The active role of the tumor stroma in regulating cell invasion.
13.1. The stroma enhances malignant cancer progression.
13.2. Biomechanical alterations in cancer cells.
13.3. Extracellular matrix evoked alterations in cancer cell functions.
13.4. Biomechanical alterations in multicellular spheroids.
13.5. Biomechanical alterations of extracellular matrix stroma in cancer.
13.6. Stromal influence on the behavior of cancer cells.
13.7. How can the extracellular matrix of the stroma be mimicked?.
13.8. The stroma decreases malignant cancer progression.
13.9. How is the dual role of the stroma affected? part VI. The impact of the mechanical and biochemical interaction of cancer cells with other cells in transendothelial migration.
14. The impact of the mechanical and biochemical interaction of cancer cells with other cells in transendothelial migration.
14.1. The expression of cell-cell adhesion molecules.
14.2. The strength of cell-cell adhesions.
14.3. The cancer cell transmigration route.
14.4. The role of cancer cell exerted invadopodia during transendothelial migration.
14.5. Tumor extracellular vesicles and interaction with the vascular system such as endothelial cells and immune cells 15. The mechanical properties of endothelial cells altered by aggressive cancer cells.
15.1. The role of endothelial cell stiffness.
15.2. The role of the endothelial contractile apparatus.
15.3. Interaction between cancer cells and endothelial cells in 3D spheroids 16. The role of macrophages during cancer cell transendothelial migration.
16.1. What is the role of macrophages during cancer disease?.
16.2. Impact of Mena on cancer cell invasion and macrophages.
16.3. Impact of Mena on macrophages.
16.4. Impact of Notch and Mena signaling during cancer cell and macrophage interaction. In order to increase the healing opportunities of cancer, it is important to impair the dissemination and the spreading of cancer cells from the initial tumor and the formation of metastases in other organs or tissues of the human body. The underlying physical principles of these oncological processes are a major constituent of the research field highlighted in Physics of Cancer. This completely revised second edition of is improved linguistically with multiple increases of the number of figures and the inclusion of several novel chapters such as actin filaments during matrix invasion, microtubuli during migration and matrix invasion, nuclear deformability during migration and matrix invasion, and the active role of the tumor stroma in regulating cell invasion.