Terkko Navigator / Pharmacology and Pharmacotherapy/ Feeds

Mini-ecosystems developed to test a molecules therapeutic effect

Application note: Real-time detection of Gs and Gi Signalling in living cells

Storbritannien utvärderar medicinsk cannabis

Neisseria meningitidis antimicrobial resistance in Italy, 2006-2016.

Colistin heteroresistance and the involvement of the PmrAB regulatory system in Acinetobacter baumannii.

A New Locus of Drug Resistance in the Human Cytomegalovirus UL56 Gene Revealed by in vitro Exposure to Letermovir and Ganciclovir.

In vitro susceptibility of Burkholderia cepacia complex isolated from cystic fibrosis patients to ceftazidime-avibactam and ceftolozane-tazobactam.

Do fitness costs explain the rapid spread of kelch13-C580Y substitutions conferring artemisinin resistance?

In vitro activity of ceftolozane-tazobactam against Enterobacter cloacae complex clinical isolates with differentβ-lactam resistance phenotypes.

Activity of Telavancin against S. aureus isolated from cystic fibrosis patients including those with decreased susceptibility to Ceftaroline.

Evaluation of the Adequacy of WHO revised Dosages of the First-Line Anti-Tuberculosis Drugs in Children with Tuberculosis using Population Pharmacokinetic Modeling and Simulations.

Mutations in gyrA and gyrB in Moxifloxacin-Resistant Mycobacterium avium Complex and Mycobacterium abscessus Complex Clinical Isolates.

Pharmacokinetics of a pediatric tribendimidine dose-finding study to treat hookworm infection in African children.

Extinction of Zika virus and Usutu virus by lethal mutagenesis reveals different patterns of sensitivity to three mutagenic drugs.

Cas9/CRISPR genome editing to demonstrate the contribution of Cyp51A Gly138Ser to azole resistance in Aspergillus fumigatus.

Pharmacokinetics, Safety, and Tolerability of Single and Multiple Doses of Relebactam, aβ-Lactamase Inhibitor, in Combination With Imipenem and Cilastatin in Healthy Participants.

Ten-day quadruple therapy comprising low-dose rabeprazole, bismuth, amoxicillin and tetracycline is an effective and safe first-line treatment for Helicobacter pylori infection in population with high antibiotic resistance: a prospective, multicenter

Genes and Proteins Involved in qnrS1 Induction.

Contribution of novel amino acid alterations in PmrA or PmrB to colistin resistance in mcr-negative Escherichia coli clinical isolates including major multidrug-resistant lineages O25b:H4-ST131-H30Rx and non-x.

Efficacy and Pharmacokinetics Evaluation of a Single Oral Dose of Afoxolaner against Sarcoptes scabiei in the Porcine Scabies Model for Human Infestation.

Antibacterial Activity of Human Simulated Epithelial Lining Fluid Concentrations of Ceftazidime-Avibactam Alone or in Combination with Amikacin Inhale (BAY41-6551) against Carbapenem Resistant Pseudomonas aeruginosa and Klebsiella pneumoniae.

Pharmacokinetics of Tedizolid in Plasma and Sputum of Adults with Cystic Fibrosis.

Population Pharmacokinetic Study of Amoxicillin-treated Burn Patients Hospitalized at a Tertiary Swiss Centre.

External Evaluation of a Gentamicin Infant Population Pharmacokinetic Model Using Data from a National Electronic Health Record Database.

Activity of RX-04 pyrrolocytosine protein synthesis inhibitors against multiresistant Gram-negative bacteria.

Pharmacological inhibition of the vacuolar ATPase in bloodstream form Trypanosoma brucei rescues genetic knockdown of mitochondrial gene expression.

Thailandamide: a fatty acid synthesis antibiotic that is co-expressed with a resistant target gene.

Population pharmacokinetics and cerebrospinal fluid penetration of fluconazole in adults with cryptococcal meningitis.

Molecular characterization of nasal MRSA isolates showing increasing prevalence of mupirocin resistance and associated multi-drug resistance following attempted decolonization.

Assessment of the In Vivo Activity of SPR741 in Combination with Azithromycin against Multidrug Resistant Enterobacteriaceae isolates in the Neutropenic Murine Thigh Infection model.

Gene signature holds promise for early detection of active TB

Organ-Specific Phytochemical Profiling and Antioxidant Analysis of Parthenium hysterophorus L.

Impulsivity and vitamin D in bariatric surgery candidates.

Effect of selected drugs on zinc accumulation in teeth of laboratory animals.

Identification of a Novel EF-Loop in the N-terminus of TRPM2 Channel Involved in Calcium Sensitivity.

Mitochondrial Delivery of Phenol Substructure Triggers Mitochondrial Depolarization and Apoptosis of Cancer Cells.

Efficacy and Safety of Once-Weekly Semaglutide for the Treatment of Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Preclinical Animal Models for Dravet Syndrome: Seizure Phenotypes, Comorbidities and Drug Screening.

Use of Submicron Vaterite Particles Serves as an Effective Delivery Vehicle to the Respiratory Portion of the Lung.

The Therapeutic Efficacy of Danhong Injection Combined With Percutaneous Coronary Intervention in Acute Coronary Syndrome: A Systematic Review and Meta-Analysis.

Regorafenib: A Review in Hepatocellular Carcinoma.

Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide: A Review in HIV-1 Infection.

Targeting EGFR in Lung Cancer: Current Standards and Developments.

The Evolution of Lung Transplant Immunosuppression.

Experiences of guilt, shame and blame in those affected by burns: A qualitative systematic review

Potential PGPR properties of cellulolytic, nitrogen-fixing, and phosphate-solubilizing bacteria of a rehabilitated tropical forest soil

Correction to: Polymyxin B causes DNA damage in HK-2 cells and mice.

Xenobiotica-metabolizing enzymes in the skin of rat, mouse, pig, guinea pig, man, and in human skin models.

Opioid analgesic drugs and serotonin toxicity (syndrome): mechanisms, animal models, and links to clinical effects.

A phase I study of LY3164530, a bispecific antibody targeting MET and EGFR, in patients with advanced or metastatic cancer