Terkko Navigator / Pharmacology and Pharmacotherapy/ Feeds

Triterpene saponins from the roots of Acacia senegal (L.) Willd.

Phytochemical and anti-inflammatory properties of Senegalese propolis and isolated compounds

Characteristics to consider when selecting a positive control material for an in vitro assay

Guidelines for FAIR sharing of preclinical safety and off-target pharmacology data

Mind the gaps: Prioritizing activities to meet regulatory needs for acute systemic lethality

An alternative in vivo model to evaluate pluripotency of patient-specific iPSCs

Sensitization potential of medical devices detected by in vitro and in vivo methods

Identifying, naming and documenting of test and tool compound stocks

TEDD Annual Meeting 2020: 10th anniversary - 10 years of innovation in tissue engineering

A new gold standard: Paradigm shift in research on human diseases and therapy developments

Replacing fetal bovine serum (FBS) in research and testing

Summer school on innovative approaches in science

Virtual class on alternative methods: Ethics and science

Using the monocyte activation test as a stand-alone release test for medical devices

NAM-supported read-across: From case studies to regulatory guidance in safety assessment

Pyrogen testing revisited on occasion of the 25th anniversary of the whole blood monocyte activation test

In vitro assessment of tick-borne encephalitis vaccine: Suitable human cell platforms and potential biomarkers

Detection of low levels of genotoxic compounds in food contact materials using an alternative HPTLC-SOS-Umu-C assay

Predicting the transfer of contaminants in ruminants by models - potentials and challenges

Modular micro-physiological human tumor/tissue models based on decellularized tissue for improved preclinical testing

Clean bioprinting - Fabrication of 3D organ models devoid of animal components

Predicting human tissue exposures to xenobiotics using a bottom-up physiologically-based biokinetic model

Associations between clinical signs and pathological findings in toxicity testing

Performance of monocyte activation test supplemented with human serum compared to fetal bovine serum

TBBPA targets converging key events of human oligodendrocyte development resulting in two novel AOPs

Driver mutations in major lung cancer oncogenes can be analyzed in Drosophila models

Grouping of UVCB substances with new approach methodologies (NAMs) data

Measuring endogenous corticosterone in laboratory mice - a mapping review, meta-analysis, and open source database

Consensus Statement from the European Network of 3R Centres (EU3Rnet)

Galleria mellonella as an alternative in vivo model to study bacterial biofilms on stainless steel and titanium implants

Chemical concentrations in cell culture compartments (C5) - free concentrations

R2N and the use of alternative methods in COVID-19 research

Innovative in vitro strategies for food and environmental safety

Increasing the availability of quality human tissue for research

Non-aversive mouse handling techniques: A survey on the acceptance and concerns of the animal facility and scientific staff

Limitations and uncertainties of acute fish toxicity assessments can be reduced using alternative methods

Predictivity of the kinetic direct peptide reactivity assay (kDPRA) for sensitizer potency assessment and GHS subclassification

3D fluid-dynamic ovarian cancer model resembling systemic drug administration for efficacy assay

Extending the applicability domain of the human cell line activation test (h-CLAT)

Making better use of toxicity studies for human health by extrapolating across endpoints

Corrigendum to An advanced in vitro model to assess glaucoma onset

Setting the trend for the alternatives movement in India: The Second National Conference of the Society for Alternatives to Animal Experiments-India

Virtual Summer School: Alternative methods and models in science: A multidisciplinary in vitro approach

Swiss-Chinese cooperation for organs-on-a-chip and stem cell research

2nd Centro3R Annual Meeting: 3Rs in Italian universities

Good Cell and Tissue Culture Practice 2.0 (GCCP 2.0) - Draft for stakeholder discussion and call for action

Automated screening for oxidative or methylation-induced DNA damage in human cells

Infectability of human BrainSphere neurons suggests neurotropism of SARS-CoV-2

Tradition, not science, is the basis of animal model selection in translational and applied research

Examination of microcystin neurotoxicity using central and peripheral human neurons