Terkko Navigator / Pharmacology and Pharmacotherapy/ Feeds

In Vivo Emergence of a Novel Protease Inhibitor Resistance Signature in HIV-1 Matrix

Correlated evolution between heat tolerance and thermal performance curves in Drosophila subobscura

Hidden dynamic signatures drive substrate selectivity in the disordered phosphoproteome

MrDNA: A multi-resolution model for predicting the structure and dynamics of nanoscale DNA objects

Combining machine learning and a universal acoustic feature-set yields efficient automated monitoring of ecosystems

Combining high-resolution AFM with MD simulations shows that DNA supercoiling induces kinks and defects that enhance flexibility and recognition.

Comparing current noise in biological and solid-state nanopores

From the Editor-in-Chief's Desk

Inferring translational heterogeneity from ribosome profiling data

The Trk fused gene-product (Tfg) is part of a 600-700kDa CARMA1 complex

A female patient with retinoblastoma and severe intellectual disability carrying an X;13 balanced translocation without rearrangement in the RB1 gene: a case report

Local axonal conduction delays underlie precise timing of a neural sequence

Trans-acting role of the leader peptide peTrpL in posttranscriptional regulation of multiresistance

Verbal suggestions of nicotine content modulate ventral tegmental neural activity during the presentation of a nicotine-free odor in cigarette smokers

Rapanone, a naturally occurring benzoquinone, inhibits mitochondrial respiration and induces HepG2 cell death

Antiplasmodial natural products: an update

Metagenomic shotgun analyses reveal complex patterns of intra- and interspecific variation in the intestinal microbiomes of codfishes

Glial cell mechanosensitivity is reversed by adhesion cues

Antibiograms and Molecular Characterization of Drug Resistance of Mycobacterium abscessus complex from Patients with Multidrug-Resistant Pulmonary Tuberculosis (MDR TB) Infection

The nucleus acts as a ruler tailoring cell responses to spatial constraints

Contaminant levels and endocrine disruptive effects in Clarias gariepinus exposed to simulated leachate from a solid waste dumpsite in Calabar, Nigeria

The human organic cation transporter OCT1 and its role as a target for drug responses

Clinical and genetic predictors of diabetes drug’s response

Aldehyde oxidase at the crossroad of metabolism and preclinical screening

Bioactivation of herbal constituents: mechanisms and toxicological relevance

Systemic drugs with impact on osteoarthritis

Quantifying fetal alcohol exposure by meconium fatty acid ethyl esters (FAEE); association with adverse fetal outcomes and population estimates of fetal alcohol exposure

Commercially available bone graft substitutes: the impact of origin and processing on graft functionality

Ethanol and its metabolites: update on toxicity, benefits, and focus on immunomodulatory effects

Current evidence on thyroid related adverse events in patients treated with protein tyrosine kinase inhibitors

Target genes associated with lipid and glucose metabolism in non-alcoholic fatty liver disease

Phyllanthus emblica fruit extract attenuates lipid metabolism in 3T3-L1 adipocytes via activating apoptosis mediated cell death

New treatment possible to tackle drug-resistant strains of TB

Cancer immunotherapies may be improved with early immune response

Two new retinal pigment epithelial cell models developed

Common signalling pathway across cancer and diabetes discovered by researchers

Regulatory asymmetry in the negative single-input module network motif: Role of network size, growth rate and binding affinity

An unsupervised feature extraction and selection strategy for identifying epithelial-mesenchymal transition state metrics in breast cancer and melanoma

Clair: Exploring the limit of using a deep neural network on pileup data for germline variant calling

Conceptual models of entrainment, jet-lag, and seasonality

Clinical outcomes following conservative and surgical management of floating shoulder injuries: a systematic review

Pregnane X receptor activation by its natural ligand Ginkgolide-A improves tight junction proteins expression and attenuates bacterial translocation in cirrhosis

Sickle cell disease celebration

RNAi agents score an approval and drive an acquisition

The nucleus measures shape deformation for cellular proprioception and regulates adaptive morphodynamics

Determination of secretory granule maturation times in pancreatic islet beta-cells by serial block face scanning electron microscopy

Sensing Traction Force on Matrix Induces Cell-Cell Distant Mechanical Communications for Self-assembly

Identification of a functional small non-coding RNA encoded by African swine fever virus

Parallel siRNA screens to identify kinase and phosphatase modulators of NF-κB activity following DNA damage

Investigating the Role of Hypoxia-Induced Migration in Glioblastoma Growth Rates