Terkko Navigator / Pharmacology and Pharmacotherapy/ Feeds

Differences in signalling, trafficking and glucoregulatory properties of glucagon-like peptide-1 receptor agonists exendin-4 and lixisenatide

A model to study NMDA receptors in early nervous system development

Biased M1 positive allosteric modulators reveal novel role of phospholipase D in M1-dependent rodent cortical plasticity

Integrating healthcare and research genetic data empowers the discovery of 49 novel developmental disorders

Selective Translation Complex Profiling Reveals Staged Initiation and Co-translational Assembly of Initiation Factor Complexes

Selective 40S footprinting reveals that scanning ribosomes remain cap-tethered in human cells

Identification Of Peptides Interfering The LRRK2/PP1 Interaction

A memory of RPS25 loss drives resistance phenotypes

Dis3L2 regulates cellular proliferation through a PI3-Kinase dependent signalling pathway

Extracellular ATP and CD39 activate cAMP-mediated mitochondrial stress response to promote cytarabine resistance in acute myeloid leukemia

AKT2 deficiency causes sarcopenia and metabolic disorder of skeletal muscle

Polyadenylation of Histone H3.1 mRNA Promotes Cell Transformation by Displacing H3.3 from Gene Regulatory Elements

DNA hydroxymethylation reveals transcription regulation networks and prognostic signatures in multiple myeloma

Exosomes transmit retroelement RNAs to drive inflammation and immunosuppression in Ewing Sarcoma

In vivo imaging defines vascular interplay in the development of lymphocytic leukemia in zebrafish models

Rescuing the attentional performance of rats with cholinergic losses by the M1 positive allosteric modulator TAK-071

Pharmacogenetic determinants of kidney-associated urinary and serum abnormalities in antiretroviral-treated HIV-positive patients

Coding and noncoding somatic mutations in basal cell carcinoma

Modulating Sphingosine-1-Phosphate receptors to improve chemotherapy delivery to Ewing sarcoma

Low dose Cold Atmospheric Plasma induces membrane oxidation, stimulates endocytosis and enhances uptake of nanomaterials in Glioblastoma multiforme cells

Analysis of the FBXO7 promoter reveals overlapping Pax5 and c-Myb binding sites functioning in B cells

Denitrification responses to increasing cadmium exposure in Baltic Sea sediments

[ASAP] Nitrate and Phosphate Transporters Rescue Fluoride Toxicity in Yeast

Inhaled gold nanoparticles cause cerebral edema and upregulate endothelial aquaporin 1 expression, involving caveolin 1 dependent repression of extracellular regulated protein kinase activity

Quantitative systems toxicology (QST) reproduces species differences in PF‐04895162 liver safety due to combined mitochondrial and bile acid toxicity

Issue Information

GSTZ1 genotypes correlate with dichloroacetate pharmacokinetics and chronic side effects in multiple myeloma patients in a pilot phase 2 clinical trial

The hubris and humility of cancer pharmacology in the post immuno‐oncology era

Selective inhibitor could reduce resistance to cancer therapies

Platform may find new options for mental health treatment

Drug Combination Antagonism and Single Agent Dominance Result from Differences in Death Activation Kinetics

Enzyme Catalytic Activity Emulated Within DNA-based Nanodevice

HPLC-DAD-ESI-QTOF-MS/MS profiling of Zygophyllum album roots extract and assessment of its cardioprotective effect against deltamethrin-induced myocardial injuries in rat, by suppression of oxidative stress-related inflammation and apoptosis via NF-κ

Reduction of blood glucose by plant extracts and their use in the treatment of diabetes mellitus; discrepancies in effectiveness between animal and human studies

Protective effect of Liuwei Dihuang Pill on cisplatin-induced reproductive toxicity and genotoxicity in male mice

Gastrointestinal and uterine smooth muscles relaxant and anti-inflammatory effects of corchorus olitorius leaf extract in laboratory animal models

Structural characterization and anticomplement activities of three acidic homogeneous polysaccharides from Artemisia annua

Euryops arabicus displays anti-inflammatory activities in experimental models

Astrocaryum aculeatum fruit improves inflammation and redox balance in phytohemagglutinin-stimulated macrophages

Pharmacodynamics and pharmacokinetics of Danshen in isoproterenol-induced acute myocardial ischemic injury combined with Honghua

Mechanistic and therapeutic study of novel anti-tumor function of natural compound imperialine for treating non-small cell lung cancer

In vitro anti-inflammatory properties of Smilax campestris aqueous extract in human macrophages, and characterization of its flavonoid profile

Protective role of cinnabar and realgar in Hua-Feng-Dan against LPS plus rotenone-induced neurotoxicity and disturbance of gut microbiota in rats

Antiplasmodial activity of triterpenes isolated from the methanolic leaf extract of Combretum racemosum P. Beauv

Ganoderma lucidum spore oil induces apoptosis of breast cancer cells in vitro and in vivo by activating caspase-3 and caspase-9

Ameliorative effects of Hydrolea zeylanica in streptozotocin-induced oxidative stress and metabolic changes in diabetic rats

Anti-hyperglycemic and anti-hyperlipidemic effects of a special fraction of Luohanguo extract on obese T2DM rats

Microneedles coated with peanut allergen enable desensitization of peanut sensitized mice

In vitro release testing methods for drug-releasing vaginal rings

Stromal-targeting radioimmunotherapy mitigates the progression of therapy-resistant tumors