Table of Contents

Front Cover; Neurovirology; Copyright; Available titles; Foreword; Preface; Contributors; Contents; Section 1: Introduction; Chapter 1: A history of viral infections of the central nervous system: foundations, milestones, and patterns; Introduction; Foundations; Hippocratic medicine and Galen; Germ theory of disease: Pasteur and Koch; The discovery of viruses; Tobacco mosaic virus; Foot and mouth disease; Yellow fever; Milestones; The first "filterable" viral diseases of the nervous system: rabies and polio; Rabies; Polio; Epidemics of viral encephalitis; St. Louis encephalitis. Experimental allergic encephalomyelitis (EAE) and ADEMGray matter and ADEM; PNS in ADEM; Relapsing ADEM; Slow viral encephalitis/encephalopathy; Viral aseptic meningitis; Wallgren and acute aseptic meningitis; Viral myelitis; Poliomyelitis; Herpes B virus; Rabies; Herpes family viruses; Chronic retroviral myelitis; Tropical spastic paraparesis/HTLV-1-associated myelopathy (HAM/TSP); HIV-associated vacuolar myelopathy; Conclusions: patterns observed and patterns predicted; References; Chapter 2: Basics of Virology; Introduction; What is a Virus?; Virus Taxonomy and Nomenclature. Japanese B encephalitisAustralian X disease and Murray Valley encephalitis; Western equine encephalomyelitis; Eastern equine encephalomyelitis (EEE); Venezuelan equine encephalomyelitis (VEE); West Nile fever; Tick-borne encephalitis (TBE); Omsk hemorrhagic fever, Kyasanur Forest disease, and Powasson virus; California encephalitis/La Crosse encephalitis; Nipah encephalitis; Sporadic viral encephalitis; Herpes simplex encephalitis; Acute disseminated encephalomyelitis (ADEM); Postvaccinial encephalomyelitis; Neuroparalytic accidents following rabies treatment. Reverse Transcribing Viruses (Baltimore class VI)Retroviruses; Fundamental Aspects of Viral Pathogenesis; Immunity to Viruses; Diagnosis of Viral Infections; Antivirals; References; Chapter 3: Neuroepidemiology and the Epidemiology of Viral Infections Of the Nervous System; Introduction; A Brief Overview of Neuroepidemiology; Basic Epidemiologic Terms and Concepts (Lilienfeld and Stolley, 1994); Epidemiologic Studies (Lilienfeld And Stolley, 1994); Epidemiology of Viral Infections of the Nervous System; Mechanisms of viral-mediated Neurologic disease. Virion StructureVirus Origins and Evolution; Virus Origins; Virus and Host Coevolution; Mechanisms of Mutation; Evolution in the Host; Virus Replication Cycles; Overview; Entry; Gene Expression; Genome Replication; Assembly and Egress; Neurotropic Viruses; dsDna Viruses (Baltimore Class I); Herpesviruses; Polyomaviruses; Poxviruses; Reoviridae; Rna Viruses; Positive-strand Rna Viruses (Baltimore class IV); Picornaviruses; Flaviviruses; Togaviruses; Coronaviruses; Negative-strand Rna Viruses (Baltimore class V); Arenaviruses; Bunyaviruses; Orthomyxoviruses; Paramyxoviruses; Rhabdoviruses. This volume in the Handbook of Clinical Neurology series provides a complete review of the history, science and current state of neurovirology. It covers the science and clinical presentation, diagnosis, and treatment of viruses of the brain and central nervous system, and is a trusted resource for scholars, scientists, neuroscientists, neurologists, virologists, and pharmacologists working on neurovirology. Neurovirology has been significantly bolstered by modern technologies such as PCR and MRI with direct impact on isolating viruses and advancing therapeutics based on mole.