Terkko Navigator / Molecular Therapy - Nucleic Acids

Dual effects of N6-methyladenosine on cancer progression and immunotherapy

Selective suppression of polyglutamine-expanded protein by lipid nanoparticle-delivered siRNA targeting CAG expansions in the mouse CNS

Comprehensive characterization of a drug-resistance-related ceRNA network across 15 anti-cancer drug categories

Separation-related rapid nuclear transport of DNA/RNA heteroduplex oligonucleotide: unveiling distinctive intracellular trafficking

miRNA-92a-3p regulates osteoblast differentiation in patients with concomitant limb fractures and TBI via IBSP/PI3K-AKT inhibition

Exosomes derived from miR-188-3p-modified adipose-derived mesenchymal stem cells protect Parkinson’s disease

SIRT1-induced deacetylation of Akt expedites platelet phagocytosis and delays HEMEC aging

Exosomal LINC00174 derived from vascular endothelial cells attenuates myocardial I/R injury via p53-mediated autophagy and apoptosis

Tumor suppressor lnc-CTSLP4 inhibits EMT and metastasis of gastric cancer by attenuating HNRNPAB-dependent Snail transcription

Whole-genome methylation analysis reveals novel epigenetic perturbations of congenital scoliosis

Lnc(ing)RNAs to the “shock and kill” strategy for HIV-1 cure

miR-146a inhibits mitochondrial dysfunction and myocardial infarction by targeting cyclophilin D

Circular RNA in tumor metastasis

Immune-related genes with APA in microenvironment indicate risk stratification and clinical prognosis in grade II/III gliomas

miR-224-5p-enriched exosomes promote tumorigenesis by directly targeting androgen receptor in non-small cell lung cancer

Plasmid encoding microRNA-200c ameliorates periodontitis and systemic inflammation in obese mice

Osteoclast-derived small extracellular vesicles induce osteogenic differentiation via inhibiting ARHGAP1

AGO-accessible anticancer siRNAs designed with synergistic miRNA-like activity

Transcriptome-wide analysis reveals insight into tumor suppressor functions of 1B3, a novel synthetic miR-193a-3p mimic

Targeting the epigenome in in-stent restenosis: from mechanisms to therapy

circCAMSAP1 promotes osteosarcoma progression and metastasis by sponging miR-145-5p and regulating FLI1 expression

miR-4478 sensitizes ovarian cancer cells to irradiation by inhibiting Fus and attenuating autophagy

Elucidation of the Hdac2/Sp1/miR-204-5p/Bcl-2 axis as a modulator of cochlear apoptosis via in vivo/in vitro models of acute hearing loss

Hypoxic tumor-derived exosomal circular RNA SETDB1 promotes invasive growth and EMT via the miR-7/Sp1 axis in lung adenocarcinoma

SIRT1 alleviates hepatic ischemia-reperfusion injury via the miR-182-mediated XBP1/NLRP3 pathway

Long non-coding RNA linc00665 inhibits CDKN1C expression by binding to EZH2 and affects cisplatin sensitivity of NSCLC cells

miR-223-3p as a potential biomarker and player for adipose tissue dysfunction preceding type 2 diabetes onset

Efficacy, accumulation, and transcriptional profile of anti-HIV shRNAs expressed from human U6, 7SK, and H1 promoters

hsa_circNFXL1_009 modulates apoptosis, proliferation, migration, and potassium channel activation in pulmonary hypertension

miRNA in food simultaneously controls animal viral disease and human tumorigenesis

Identification of a novel RNA aptamer that selectively targets breast cancer exosomes

miR-130a activates the VEGFR2/STAT3/HIF1α axis to potentiate the vasoregenerative capacity of endothelial colony-forming cells in hypoxia

Insights into adaption and growth evolution: a comparative genomics study on two distinct cattle breeds from Northern and Southern China

Epigenetically modulated miR-1224 suppresses the proliferation of HCC through CREB-mediated activation of YAP signaling pathway

ncRNA therapy with miRNA-22-3p suppresses the growth of triple-negative breast cancer

Roles of circRNAs on tumor autophagy

Pathogenic mechanisms and the potential clinical value of circFoxo3 in cancers

MALAT1 sponges miR-26a and miR-26b to regulate endothelial cell angiogenesis via PFKFB3-driven glycolysis in early-onset preeclampsia

The role of RNA N6-methyladenosine methyltransferase in cancers

Circular RNA RBPMS inhibits bladder cancer progression via miR-330-3p/RAI2 regulation

Expanding the recognition interface of the thrombin-binding aptamer HD1 through modification of residues T3 and T12

Circular RNA circPSD3 alleviates hepatic fibrogenesis by regulating the miR-92b-3p/Smad7 axis

Blocking the IGF2BP1-promoted glucose metabolism of colon cancer cells via direct de-stabilizing mRNA of the LDHA enhances anticancer effects

Engineering highly efficient backsplicing and translation of synthetic circRNAs

circFOXM1 contributes to sorafenib resistance of hepatocellular carcinoma cells by regulating MECP2 via miR-1324

LOXL1 exerts oncogenesis and stimulates angiogenesis through the LOXL1-FBLN5/αvβ3 integrin/FAK-MAPK axis in ICC

circRNA hsa_circ_0018414 inhibits the progression of LUAD by sponging miR-6807-3p and upregulating DKK1

Oncogenic ZEB2/miR-637/HMGA1 signaling axis targeting vimentin promotes the malignant phenotype of glioma

An aptamer interacting with heat shock protein 70 shows therapeutic effects and prognostic ability in serous ovarian cancer

Angiotensin II-induced muscle atrophy via PPARγ suppression is mediated by miR-29b