Table of Contents

Cover.
Contents.
List of Contributors.
Foreword.
Preface.
CHAPTER 1: Molecular Diagnostics: Past, Present, and Future.
SECTION 1: Molecular Diagnostic Technology.
CHAPTER 2: Allele-Specific Mutation Detection by PCR-ARMS and PCR-ASO.
CHAPTER 3: Competitive Oligopriming.
CHAPTER 4: Oligonucleotide Ligation Assays for the Diagnosis of Inherited Diseases.
CHAPTER 5: Enzymatic and Chemical Cleavage Methods to Identify Genetic Variation.
CHAPTER 6: Mutation Detection by Single Strand Conformation Polymorphism and Heteroduplex Analysis.
CHAPTER 7: Capillary Electrophoresis.
CHAPTER 8: Temperature and Denaturing Gradient Gel Electrophoresis.
CHAPTER 9: Two-Dimensional Gene Scanning.
CHAPTER 10: Real-Time Polymerase Chain Reaction.
CHAPTER 11: Pyrosequencing.
CHAPTER 12: Molecular Cytogenetics in Molecular Diagnostics.
CHAPTER 13: Detection of Genomic Duplications and Deletions.
CHAPTER 14: Analysis of Human Splicing Defects Using Hybrid Minigenes.
CHAPTER 15: DNA Microarrays and Genetic Testing.
CHAPTER 16: Human Genome Microarray in Biomedical Applications.
CHAPTER 17: Use of High Throughput Mass Spectrographic Methods to Identify Disease Processes.
CHAPTER 18: The Application of Proteomics to Disease Diagnostics.
SECTION II: Applications of Molecular Diagnostics and Related Issues.
CHAPTER 19: Identification of Genetically Modified Organisms.
CHAPTER 20: Pharmacogenetics and Pharmacogenomics: Impact on Drug Discovery and Development.
CHAPTER 21: Molecular Diagnostic Applications in Forensic Science.
CHAPTER 22: Molecular Diagnostics and Comparative Genomics in Clinical Microbiology.
CHAPTER 23: Preimplantation Genetic Diagnosis.
CHAPTER 24: Genetic Monitoring of Laboratory Animals.
CHAPTER 25: The Use of Locus-Specific Databases in Molecular Diagnostics.
CHAPTER 26: Safety Analysis in Retroviral Gene Therapy: Identifying Virus Integration Sites in Gene-Modified Cells.
CHAPTER 27: Automated DNA Hybridization and Detection.
CHAPTER 28: The Use of Microelectronic-Based Techniques in Molecular Diagnostic Assays.
CHAPTER 29: Miniaturization Technologies for Molecular Diagnostics.
CHAPTER 30: Human Gene Patents and Genetic Testing.
CHAPTER 31: Genetic Counselling and Ethics in Molecular Diagnostics.
CHAPTER 32: Genetic Testing and Psychology.
CHAPTER 33: Safety in Biomedical and Other Laboratories.
CHAPTER 34: Quality Management in the Laboratory.
Glossary.
Index.
Last Page. Exclusively dedicated to diagnosis of inherited diseases at the molecular level.