Table of Contents

Part I. Microbial glycolipids, glyoproteins and glycopolymers€ 1. Overview of the glycosylated components of the bacterial cell wall€€ 2. Bacterial cell wall envelope peptidoglycan€€ 3. Core oligosaccharide and lipid A components of lipopolysaccharides€€ 4. O-Specific polysaccharides of Gram-negative bacteria€€ 5. Teichoic acids, lipoteichoic acids, and related cell wall glycopolymers of Gram-positive bacteria€€ 6. Bacterial capsular polysaccharides and exopolysaccharides€€ 7. Bacterial surface layer glycoproteins and "non-classical" secondary cell wall polymers€€ 8. Glycosylation of bacterial and archaeal flagellins€€ 9. Glycosylated components of the mycobacterial cell wall: structure and function€€ 10. Glycoconjugate structure and function in fungal cell walls€€ 11. Cytoplasmic carbohydrate molecules: trehalose and glycogen€€ 12. Glycosylated compounds of parasitic protozoa€€ 13. Analytical approaches towards the structural characterization of microbial wall glycopolymers€€ 14. Single-molecule characterization of microbial polysaccharides€€ 15. Viral surface glycoproteins in carbohydrate recognition: structure and modeling€Part II. Synthesis of microbial glycosylated components; A. Biosynthesis and biosynthetic processes€ 16. Biosynthesis of bacterial peptidoglycan€€ 17. Biosynthesis and membrane assembly of lipid A€€ 18. Biosynthesis of O-antigen chains and assembly€€ 19. Biosynthesis of cell wall teichoic acid polymers€€ 20. Biosynthesis and assembly of capsular polysaccharides€€ 21. Biosynthesis of the mycobacterial cell envelope components€€ 22. Biosynthesis of fungal and yeast glycans€B. Chemical synthesis€€ 23. Chemical synthesis of bacterial lipid A€€ 24. Chemical synthesis of the core oligosaccharide of bacterial lipopolysaccharide€€ 25. Chemical synthesis of lipoichoic acid and derivatives€€ 26. Chemical synthesis of parasitic glycoconjugates and phosphoglycans€ Part III. Microbe-host glycosylated interactions€€ 27. Bacterial lectin-like interactions in cell recognition and adhesion€€ 28. Lectin-like interactions in virus-cell recognition: human immunodeficiency virus and C-type lectin interactions€€ 29. Sialic acid-specific microbial lectins€€€ 30. Bacterial toxins and their carbohydrate receptors at the host-pathogen interface€€ 31. Toll-like receptor recognition of lipoglycans, glycolipids and lipopeptides€€ 32. NOD receptor recognition of peptidoglycan€€ 33. Microbial interaction with mucus and mucins€€ 34. Mannose-fucose recognition by DC-SIGN€€ 35. Host surfactant proteins in microbial recognition€€ 36. T-cell recognition of microbial lipoglycans and glycolipids€ Part IV. Biological relevance of microbial glycosylated components; A. Environmental relevance€€ 37. Extracellular polymeric substances in microbial biofilms€€ 38. Physico-chemical properties of microbial glycopolymers€€ 39. Microbial biofilm-related polysaccharides in biofouling and corrosion€€ 40. Microbial glycosylated components in plant disease€€B. Medical relevance€€ 41. Antigenic variation of microbial surface glycosylated molecules€€ 42. Phase variation of bacterial surface glycosylated molecules in immune evasion€€ 43. Molecular mimicry of host glycosylated structures by bacteria€€ 44. Role of microbial glycosylation in host cell invasion€ Part V. Biotechnological and medical applications€€ 45. Exopolysaccharides produced by lactic acid bacteria in food and probiotic applications€€ 46. Industrial exploitation by genetic engineering of bacterial glycosylation systems€€ 47. Glycomimetics as inhibitors in anti-infection therapy€€ 48. Bacterial polysaccharide vaccines: glycogonjugates and peptide-mimetics€€ 49. Immunomodulation by zwitterionic polysaccharides€€ 50. Future potential of glycomics in microbiology and infectious diseases€ This book presents in an easy-to-read format a summary of the important central aspects of microbial glycobiology, i.e. the study of carbohydrates as related to the biology of microorganisms. Microbial glycobiology represents a multidisciplinary and emerging area with implications for a range of basic and applied research fields, as well as having industrial, medical and biotechnological implications. Key Features and Benefits * Individual chapters provided by leading international scientists in the field yield insightful, concise and stimulating reviews. - Provides researchers with an overview and synthesis of the latest research * Each chapter begins with a brief 200 word Summary/Abstract detailing the topic and focus of the chapter, as well as the concepts to be addressed. - Allows researchers to see at a glance what each chapter will cover * Each chapter includes a Research Focus Box - Identifies important problems that still need to be solved and areas that require further investigation.