Table of Contents

Principles of human energy metabolism.
Intermediary metabolsim of carbohydrate, protein, and fat.
Adipose tissue development, structure and function.
Adipokines in health and disease.
Neural control of feeding and energy homeostasis.
Gastrointestinal hormones and obesity.
Genes and human obesity.
Classical hormones linked to obesity.
Inflammation and adipose dysfunction.
Insulin resistance in the metabolic syndrome.
Pancreatic islet ß-cell failure in obesity.
Non-alcoholic fatty liver disease.
Sleep, circadian rhytms and metabolism.
Obesity and cardiac dysfunction.
Atherogenic lipid metabolism in obesity.
Gut microbes, immunity, and metabolism.
Impact of obesity on female reproductive health.
Lessons from HIV lipodystrophy.
Principles of obesity therapy. The obesity epidemic has generated immense interest in recent years due to the wide-ranging and significant adverse health and economic consequences that surround the problem. Much attention has been focused on behaviors that lead to obesity, in particular to over consumption of energy-dense food and to sedentary lifestyle. However, obesity is an extremely complex condition with poorly defined pathogenesis. Thanks to greatly enhanced research in the area, the discovery of pathways in the brain and peripheral organs that mediate energy homeostasis has provided a framework for understanding the.