Terkko Navigator / Lehti, K(aisa)

Molecular, cellular and systemic aspects of epithelial ovarian cancer and its tumor microenvironment

Chemotherapy as a regulator of extracellular matrix-cell communication: implications in therapy resistance

FOXP3+ T cells in uterine sarcomas are associated with favorable prognosis, low extracellular matrix expression and reduced YAP activation

Phosphodiesterase type 5 inhibitor (sildenafil) - impact in proliferative diabetic retinopathy?

Proliferative diabetic retinopathy transcriptomes reveal angiogenesis, anti-angiogenic therapy escape mechanisms, fibrosis and lymphatic involvement

WNT2 activation through proximal germline deletion predisposes to small intestinal neuroendocrine tumors and intestinal adenocarcinomas

Sarcoma Tumor Microenvironment

Co-evolution of matrisome and adaptive adhesion dynamics drives ovarian cancer chemoresistance

Aggressive and recurrent ovarian cancers upregulate ephrinA5, a non-canonical effector of EphA2 signaling duality

CD11c-CD8 Spatial Cross Presentation: A Novel Approach to Link Immune Surveillance and Patient Survival in Soft Tissue Sarcoma

Mesothelin-specific CAR T cells target ovarian cancer

Multi-modal meta-analysis of cancer cell line omics profiles identifies ECHDC1 as a novel breast tumor suppressor

Crosstalk Between Cancer Associated Fibroblasts and Cancer Cells in Scirrhous Type Gastric Cancer

Adaptive RSK-EphA2-GPRC5A signaling switch triggers chemotherapy resistance in ovarian cancer

PTPRA Phosphatase Regulates GDNF-Dependent RET Signaling and Inhibits the RET Mutant MEN2A Oncogenic Potential

Thermal Proteome Profiling Identifies Oxidative-Dependent Inhibition of the Transcription of Major Oncogenes as a New Therapeutic Mechanism for Select Anticancer Compounds

High tissue MMP14 expression predicts worse survival in gastric cancer, particularly with a low PROX1

MMP14 in Sarcoma: A Regulator of Tumor Microenvironment Communication in Connective Tissues

A novel mutation in the matrix metallopeptidase 2 coding gene associated with intrafamilial variability of multicentric osteolysis, nodulosis, and arthropathy

Vulnerability of invasive glioblastoma cells to lysosomal membrane destabilization

FGFR4 phosphorylates MST1 to confer breast cancer cells resistance to MST1/2-dependent apoptosis

An Ex Vivo Tissue Culture Model for Fibrovascular Complications in Proliferative Diabetic Retinopathy

Soluble and membrane-bound adenylate kinase and nucleotidases augment ATP-mediated inflammation in diabetic retinopathy eyes with vitreous hemorrhage

Integrated Molecular Analysis of Undifferentiated Uterine Sarcomas Reveals Clinically Relevant Molecular Subtypes

Lymphatic Vascular Structures: A New Aspect in Proliferative Diabetic Retinopathy

Liprin-α1 modulates cancer cell signaling by transmembrane protein CD82 in adhesive membrane domains linked to cytoskeleton

PROX1 is a transcriptional regulator of MMP14

Fibroblasts in the Tumor Microenvironment: Shield or Spear?

A Functional Homologous Recombination Assay Predicts Primary Chemotherapy Response and Long-Term Survival in Ovarian Cancer Patients

Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 andβ1-integrin activation

The microenvironment of proliferative diabetic retinopathy supports lymphatic neovascularization

Membrane-type matrix metalloproteases as diverse effectors of cancer progression

RhoA knockout fibroblasts lose tumor-inhibitory capacity in vitro and promote tumor growth in vivo

Somatic MED12 Nonsense Mutation Escapes mRNA Decay and Reveals a Motif Required for Nuclear Entry

Liprin-α1 is a regulator of vimentin intermediate filament network in the cancer cell adhesion machinery

Proactive for invasion: Reuse of matrix metalloproteinase for structural memory

Quantitative Proteomics Analysis of Vitreous Humor from Diabetic Retinopathy Patients

A Case of Abnormal Lymphatic-Like Differentiation and Endothelial Progenitor Cell Activation in Neovascularization Associated with Hemi-Retinal Vein Occlusion

Indications of lymphatic endothelial differentiation and endothelial progenitor cell activation in the pathology of proliferative diabetic retinopathy

MMP16 Mediates a Proteolytic Switch to Promote Cell-Cell Adhesion, Collagen Alignment, and Lymphatic Invasion in Melanoma

Identification of 33 candidate oncogenes by screening for base-specific mutations

Actin-associated protein palladin promotes tumor cell invasion by linking extracellular matrix degradation to cell cytoskeleton

Eph- and ephrin-dependent mechanisms in tumor and stem cell dynamics

Increased intravitreal angiopoietin-2 levels associated with rhegmatogenous retinal detachment

EphA2 bears plasticity to tumor invasion

EphA2 cleavage by MT1-MMP triggers single cancer cell invasion via homotypic cell repulsion

Ang-2 upregulation correlates with increased levels of MMP-9, VEGF, EPO and TGFβ1 in diabetic eyes undergoing vitrectomy

An optimized isolation of biotinylated cell surface proteins reveals novel players in cancer metastasis

MT1-MMP inactivates ADAM9 to regulate FGFR2 signaling and calvarial osteogenesis

KSHV-initiated notch activation leads to membrane-type-1 matrix metalloproteinase-dependent lymphatic endothelial-to-mesenchymal transition