Terkko Navigator / Laboratory Investigation

Differential regulation of claudin-2 and claudin-15 expression in children and adults with malabsorptive disease

Genetic alterations in cell cycle regulation-associated genes may promote primary progression of gastrointestinal stromal tumors

PI3K/Akt pathway-mediated HO-1 induction regulates mitochondrial quality control and attenuates endotoxin-induced acute lung injury

Inhibition of microRNA-21-5p reduces keloid fibroblast autophagy and migration by targeting PTEN after electron beam irradiation

Inside the USCAP Journals

The Shh/Gli signaling cascade regulates myofibroblastic activation of lung-resident mesenchymal stem cells via the modulation of Wnt10a expression during pulmonary fibrogenesis

Bone marrow mesenchymal stem cell-derived exosomal miR-144-5p improves rat ovarian function after chemotherapy-induced ovarian failure by targeting PTEN

Blockade of intercellular adhesion molecule-1 prevents angiotensin II-induced hypertension and vascular dysfunction

Prostaglandin E2 receptor EP1 (PGE2/EP1) deletion promotes glomerular podocyte and endothelial cell injury in hypertensive TTRhRen mice

Fatty acid beta oxidation enzyme HADHA is a novel potential therapeutic target in malignant lymphoma

RIP1/RIP3/MLKL mediates dopaminergic neuron necroptosis in a mouse model of Parkinson disease

Automated computerized image analysis for the user-independent evaluation of disease severity in preclinical models of NAFLD/NASH

Impairment of autophagy in scrapie-infected transgenic mice at the clinical stage

Inside the USCAP Journals

The NanoSuit method: a novel histological approach for examining paraffin sections in a nondestructive manner by correlative light and electron microscopy

Antifibrotic effects of hypocalcemic vitamin D analogs in murine and human hepatic stellate cells and in the CCl4 mouse model

The high-density lipoprotein receptor Scarb1 is required for normal bone differentiation in vivo and in vitro

JAK2/STAT1-mediated HMGB1 translocation increases inflammation and cell death in a ventilator-induced lung injury model

TRPM7 mediates kidney injury, endothelial hyperpermeability and mortality during endotoxemia

Blockade of MDM2 with inactive Cas9 prevents epithelial to mesenchymal transition in retinal pigment epithelial cells

Correction: Micheliolide ameliorates renal fibrosis by suppressing the Mtdh/BMP/MAPK pathway

Selective Ah receptor modulators attenuate NPC1L1-mediated cholesterol uptake through repression of SREBP-2 transcriptional activity

TRPV4 is dispensable for the development of airway allergic asthma

Development of a simple osteoarthritis model useful to predict in vitro the anti-hypertrophic action of drugs

Lipid droplet velocity is a microenvironmental sensor of aggressive tumors regulated by V-ATPase and PEDF

Retinoid-related orphan nuclear receptor alpha (RORα)-deficient mice display morphological testicular defects

Murine neuroblastoma cell lines developed by conditional reprogramming preserve heterogeneous phenotypes observed in vivo

SnoN residue (1–366) attenuates hypertrophic scars through resistance to transforming growth factor-β1-induced degradation

Quantitative assessment of PD-L1 as an analyte in immunohistochemistry diagnostic assays using a standardized cell line tissue microarray

NSG mice as hosts for oncological precision medicine

Muc5ac null mice are predisposed to spontaneous gastric antro-pyloric hyperplasia and adenomas coupled with attenuated H. pylori-induced corpus mucous metaplasia

Inside the USCAP Journals

TERT assists GDF11 to rejuvenate senescent VEGFR2+/CD133+ cells in elderly patients with myocardial infarction

GEAMP, a novel gastroesophageal junction carcinoma cell line derived from a malignant pleural effusion

Ang-(1-7) treatment attenuates lipopolysaccharide-induced early pulmonary fibrosis

Search for novel STAT3-dependent genes reveals SERPINA3 as a new STAT3 target that regulates invasion of human melanoma cells

Cas9-based enrichment and single-molecule sequencing for precise characterization of genomic duplications

Inside the USCAP Journals

TNFAIP2 expression induces epithelial-to-mesenchymal transition and confers platinum resistance in urothelial cancer cells

A new role for host annexin A2 in establishing bacterial adhesion to vascular endothelial cells: lines of evidence from atomic force microscopy and an in vivo study

Wisteria floribunda agglutinin staining for the quantitative assessment of cardiac fibrogenic activity in a mouse model of dilated cardiomyopathy

Thy-1 depletion and integrin β3 upregulation-mediated PI3K-Akt-mTOR pathway activation inhibits lung fibroblast autophagy in lipopolysaccharide-induced pulmonary fibrosis

Role of prion protein glycosylation in replication of human prions by protein misfolding cyclic amplification

Promotion of β-catenin/Foxo1 signaling ameliorates renal interstitial fibrosis

Differential engagement of ORAI1 and TRPC1 in the induction of vimentin expression by different stimuli

Ascl1-induced Wnt11 regulates neuroendocrine differentiation, cell proliferation, and E-cadherin expression in small-cell lung cancer and Wnt11 regulates small-cell lung cancer biology

Deep learning assisted mitotic counting for breast cancer

Synthetic circular multi-miR sponge simultaneously inhibits miR-21 and miR-93 in esophageal carcinoma

A DSTYK mutation activates ERK1/2 signaling to promote intraspinal dissemination in a case of solitary fibrous tumor/hemangiopericytoma

Microvascularity detection and quantification in glioma: a novel deep-learning-based framework