Terkko Navigator / JCI Insight

Targeting CAR and Nrf2 improves cyclophosphamide bioactivation while reducing doxorubicin-induced cardiotoxicity in triple-negative breast cancer treatment

A pathogenic mechanism associated with myopathies and structural birth defects involves TPM2-directed myogenesis

Biochemical, biophysical, and immunological characterization of respiratory secretions in severe SARS-CoV-2 infections

Deciphering the tumor microenvironment cell–infiltrating landscape reveals microenvironment subtypes and therapeutic potentials for nonsquamous NSCLC

Coimmunomodulation of tumor and tumor-draining lymph nodes during in situ vaccination promotes antitumor immunity

Blocking cell cycle progression through CDK4/6 protects against chronic kidney disease

Age-dependent gray matter demyelination is associated with leptomeningeal neutrophil accumulation

Alu RNA induces NLRP3 expression through TLR7 activation in α-1-antitrypsin–deficient macrophages

Immune landscape of a genetically engineered murine model of glioma compared with human glioma

Boosting corrects a memory B cell defect in SARS-CoV-2 mRNA–vaccinated patients with inflammatory bowel disease

Biological aging of CNS-resident cells alters the clinical course and immunopathology of autoimmune demyelinating disease

Cystathionine γ-lyase exacerbates Helicobacter pylori immunopathogenesis by promoting macrophage metabolic remodeling and activation

Myocardial ATP depletion detected noninvasively predicts sudden cardiac death risk in patients with heart failure

STAT1 signaling protects self-reactive T cells from control by innate cells during neuroinflammation

Tissue-localized immune responses in people with cystic fibrosis and respiratory nontuberculous mycobacteria infection

Human CD4+CD8α+ Tregs induced by Faecalibacterium prausnitzii protect against intestinal inflammation

Neutralizing antibody activity against SARS-CoV-2 variants in gestational age–matched mother-infant dyads after infection or vaccination

Cross-reactive antibodies facilitate innate sensing of dengue and Zika viruses

Bioactive extracellular vesicles from a subset of endothelial progenitor cells rescue retinal ischemia and neurodegeneration

CXCL13-producing CD4+ T cells accumulate in the early phase of tertiary lymphoid structures in ovarian cancer

Transhemispheric cortex remodeling promotes forelimb recovery after spinal cord injury

IL-4 prevents adenosine-mediated immunoregulation by inhibiting CD39 expression

Targeted gut microbiota manipulation attenuates seizures in a model of infantile spasms syndrome

Dichloroacetate improves systemic energy balance and feeding behavior during sepsis

Activated CLL cells regulate IL-17F–producing Th17 cells in miR155-dependent and outcome-specific manners

Immunization using ApoB-100 peptide–linked nanoparticles reduces atherosclerosis

Blimp-1 molds the epigenetic architecture of IL-21–mediated autoimmune diseases through an autoregulatory circuit

Vertical sleeve gastrectomy induces enteroendocrine cell differentiation of intestinal stem cells through bile acid signaling

EBAG9 controls CD8+ T cell memory formation responding to tumor challenge in mice

Decoding the PITX2-controlled genetic network in atrial fibrillation

Targeting IL-1β as an immunopreventive and therapeutic modality for K-ras–mutant lung cancer

Heteroplasmic and homoplasmic m.616T>C in mitochondria tRNAPhe promote isolated chronic kidney disease and hyperuricemia

Placental dysfunction influences fetal monocyte subpopulation gene expression in preterm birth

EBV/HHV-6A dUTPases contribute to myalgic encephalomyelitis/chronic fatigue syndrome pathophysiology by enhancing TFH cell differentiation and extrafollicular activities

JAK inhibitor blocks COVID-19 cytokine–induced JAK/STAT/APOL1 signaling in glomerular cells and podocytopathy in human kidney organoids

Multiomic analysis of microRNA-mediated regulation reveals a proliferative axis involving miR-10b in fibrolamellar carcinoma

Targeting genome integrity dysfunctions impedes metastatic potency in non–small cell lung cancer circulating tumor cell–derived explants

Immune and epithelial determinants of age-related risk and alveolar injury in fatal COVID-19

Single-cell RNA-Seq of human esophageal epithelium in homeostasis and allergic inflammation

A peptide blocking the ADORA1-neurabin interaction is anticonvulsant and inhibits epilepsy in an Alzheimer’s model

Linked sensitization by memory CD4+ T cells prevents costimulation blockade–induced transplantation tolerance

IL-17–producing follicular Th cells enhance plasma cell differentiation in lupus-prone mice

Bacillus Calmette-Guérin–induced trained immunity protects against SARS-CoV-2 challenge in K18-hACE2 mice

Lethal synergy between SARS-CoV-2 and Streptococcus pneumoniae in hACE2 mice and protective efficacy of vaccination

A phase I trial of cyclosporine for hospitalized patients with COVID-19

Accelerated waning of immunity to SARS-CoV-2 mRNA vaccines in patients with immune-mediated inflammatory diseases

Glucose supply and glycolysis inhibition shape the clinical fate of Staphylococcus epidermidis–infected preterm newborns

Single-cell transcriptomic profiling of lung endothelial cells identifies dynamic inflammatory and regenerative subpopulations

CD206+ tumor-associated macrophages cross-present tumor antigen and drive antitumor immunity

The innate immune response following multivalent dengue vaccination and implications for protection against dengue challenge