Table of Contents

Rationale and Historical Perspective of Intraoperative Irradiation.
Biology of Large Dose per Fraction Irradiation.
Intraoperative Electron Beam Irradiation: Physics and Techniques.
HDR-IORT: Physics and Techniques.
Electronic Brachytherapy/Low KV-IORT: Physics and Techniques.
IORT with Electron-Beam, High-Dose-Rate Brachytherapy or Low-KV/Electronic Brachytherapy: Methodological Comparisons.
Normal-Tissue Tolerance to IOERT, EBRT, or Both: Animal and Clinical Studies.
Central Nervous System Tumors.
Head and Neck Cancer.
Breast Cancer.
Lung Cancer.
Gastric Cancer.
Pancreas Cancer.
Bile Duct and Gallbladder Cancer.
Primary Colorectal Cancer.
Recurrent Colorectal Cancer.
Retroperitoneal Sarcomas.
Extremity and Trunk Soft-Tissue Sarcomas.
Bone Sarcomas.
Gynecologic Malignancies.
Genitourinary Cancer.
Pediatric Malignancies.
Conclusions and Future Possibilities: IORT.