Table of Contents

Insulin and the Physiology of Carbohydrate Metabolism.
Insulin/IGF-1 Signaling Nodes and their Role in Carcinogenesis.
The Mechanisms and Impact of Obesity and Insulin Resistance on Breast Cancer Incidence.
Obesity and Cancer: Epidemiology.
Insulin, Insulin Resistance, and Cancer Associations.
Animal Models of Hyperinsulinemia, Insulin Resistance, and Cancer.
Potential Mechanisms Linking Insulin to Cancer.
Actions of Insulin As a Survival and Growth Factor: Akt, mTOR, and Regulation of Translation.
AMP-Activated Protein Kinase and Cancer Cell Metabolism.
The Role of the IGF Axis in Human Malignancy: Evidence from Epidemiological Studies and Tissue Analysis.
IGF-I and Insulin Receptor Families in Cancer.
Insulin Resistance: Clinical Implications for Cancer Treatment and Prevention.