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A manual connecting pathophysiology to clinical management principles encountered on medical clerkship rotations. The author, through her own recent experiences as a medical student and resident in internal medicine, has succinctly organized foundational science learned in years one and two of medical school and provides a framework for clinical learning encountered in year three clerkship and beyond. This marriage of pathophysiology and basic treatment principles helps users make sense of clinical concepts mechanistically, rather than through memorization. Filled with visuals and pearls, this portable guide will help medical students bridge the gap between science lectures and patient wards.