Table of Contents

Acute myeloid leukemia in children.
Myelodysplastic and myeloproliferative neoplasms in children.
Pathobiology of acute lymphoblastic leukemia.
Clinical manifestations and treatment of acute lymphoblastic leukemia in children.
Acute lymphoblastic leukemia in adults.
Chronic myeloid leukemia.
The polycythemias.
Essential thrombocythemia.
Primary myelofibrosis.
Eosinophilia, eosinophil-associated diseases, chronic eosinophil leukemia, and the hypereosinophilic syndromes.
Mast cellls and systemic mastocytosis.
Pathologic basis for the classification of non-hodgkin and hodgkin lymphomas.
Origin of hodgkin lymphoma.
Hodgkin lymphoma: clinical manifestations, staging, and therapy.
Origin of non-Hodgkin lymphoma.
Chronic lymphocytic leukemia.
Hairy cell leukemia.
Clinical manifestations and treatment of marginal zone lymphomas (extranodal/malt, splenic, and nodal).
Clinical manifestations, staging, and treatment of follicular lymphoma.
Mantle cell lymphoma.
Diagnosis and treatment of diffuse large b-cell lymphoma and Burkitt lymphoma.
Virus-associated lymphoma.
Malignant lymphomas in childhood.
T-cell lymphomas.
Plasma cell neoplasms.
Waldenström macroglobulinemia and lymphoplasmacytic lymphoma.
Immunoglobulin light-chain amyloidosis (primary amyloidosis).
Clinical approach to infections in the compromised host.
Indwelling access devices.
Nutritional issues in patients with hematologic malignancies.
Psychosocial aspects of hematologic disorders.
Pain management and antiemetic therapy in hematologic disorders.
Palliative care.
Late complications of hematologic diseases and their therapies.
Overview and historical perspecitve of current cell-based therapies.
Practical aspects of hematologic stem cell harvesting and mobilization.
Preclinical process of cell-based therapies.
Graft engineering and cell processing.
Principles of cell-based genetic therapies.
Mesenchymal stromal cells.
T-cell therapy of hematologic diseases.
Natural killer cell-based therapies.
Dendritic cell therapies.
Overview of hematopoietic stem cell transplantation.
Indications and outcome of allogeneic hematopoietic cell transplantation for hematologic malignancies in adults.
Unrelated donor hematopoietic cell transplantation.
Haploidentical hematopoietic cell transplantation.
Unrelated donor cord blood transplantation for hematologic malignancies.
Graft-versus-host disease and graft-versus-leukemia responses.
Complications after hematopoietic stem cell transplantation.
Human blood group antigens and antibodies.
Principles of red blood cell transfusion.
Principles of platelet transfusion therapy.
Human leukocyte antigen and human neutrophil antigen systems.
Principles of neutrophil (granulocyte) transfusions.
Principles of plasma transfusion: plasma, cryoprecipitate, albumin, and immunoglobulins --. Anatomy and physiology of the gene.
Genomic approaches to hematology.
Regulation of gene expression, transcription, splicing, and RNA metabolism.
Protein synthesis, processing, and trafficking.
Protein architecture: relationship of form and function.
Signaling transduction and regulation of cell metabolism.
Pharmacogenomics and hematologic diseases.
Hematopoietic stem cell biology.
Hematopoietic microenvironment.
Cell adhesion.
Hematopoietic cell trafficking and chemokines.
Dynamic interactions between hematopoietic stem and progenitor cells and the bone marrow: current biology of stem cell homing and mobilization.
Vascular growth in heatlh and disease.
Principles of cytokine signaling.
Control of cell division.
Cell death.
Overview and compartmentalization of the immune system.
B-cell development.
T-cell immunity.
Natural killer cell immunity.
Dendritic cell biology.
Complement and immunoglobulin biology.
Tolerance and autoimmunity.
Biology of erythropoiesis, erythroid differentiation, and maturation.
Granulocytopoiesis and monocytopoiesis.
Inherited forms of bone marrow failure.
Aplastic anemia.
Paroxysmal nocturnal hemoglobinuria.
Acquried disorders of red cell, white cell, and platelet production.
Pathobiology of the human erythrocyte and its hemoglobins.
Approach to anemia in the adult and child.
Pathophysiology of iron homeostasis.
Disorders of iron homeostasis: iron deficiency and overload.
Anemia of chronic diseases.
Heme biosynthesis and its disorders: porphyrias and sideroblastic anemias.
Megaloblastic anemias.
Thalassemia syndromes.
Pathobiology of sickle cell disease.
Sickle cell disease: clinical features and management.
Hemoglobin variants associated with hemolytic anemia, altered oxygen affinity, and methemoglobinemias.
Red blood cell enzymopathies.
Red blood cell membrane disorders.
Autoimmune hemolytic anemia.
Extrinsic nonimmune hemolytic anemias.
Neurotrophilic leukocytosis, neurotropenia, monocytosis, and monocytopenia.
Lymphocytosis, lymphocytopenia, hypergammaglobulinemia, and hypogammaglobulinema.
Disorders of phagocyte function.
Congenital disorders of lymphocyte function.
Histiocytic disorders.
Lysosomal storage diseases: perspectives and principles.
Infections mononucleosis and other Epstein-Barr virus-associated diseases.
Progress in the classification of myeloid neoplasms: clinical implications.
Conventional and molecular cytogenetic basis of hemotologic malignancies.
Radiation therapy in the treatment of hematologic malignancies.
Pathobiology of acute myeloid leukema.
Clinical mainfestations and treatment of acute myeloid leukemia.
Myelodysplastic syndromes: biology and treatment.
Allogenic hematopoietic stem cell transplantation for acute myeloid leukemia and myelodysplastic syndrome in adults --. Preparation of plasma-derived and recombinant human plasma proteins.
Transfusion therapy for coagulation factor deficiencies.
Transfusion reactions to blood and cell therapy products.
Transfusion-transmitted diseases.
Transfusion medicine in hematopoietic stem cell and solid organ transplantation.
Pediatric transfusion medicine.
Overview of hemostasis and thrombosis.
The blood vessel wall.
Megakaryocyte and platelet structure.
Molecular basis for platelet function.
Molecular basis of blood coagulation.
Regulatory mechanisms in hemostasis.
Clinical approach to the patient with bleeding or bruising.
Laboratory evaluation of hemostatic and thrombotic disorders.
Acquired disorders of platelet function.
Diseases of platelet number: immune thrombocytopenia, neonatal alloimmune thrombocytopenia, and posttransfusion purpura.
Thrombocytopenia caused by platelet destruction, hypersplenism, or hemodilution.
Heparin-induced thrombocytopenia.
Thrombotic thrombocytopenic purpura and the hemolytic uremic syndrome.
Hemophilia A and B.
Inhibitors in hemophilia A and B.
Rare coagulation factor deficiencies.
Structure, biology, and genetics of von willebrand factor.
Disseminated intravascular coagulation.
Hypercoagulable states - Antiphospholipid syndrome.
Venous thromboembolism.
Mechanical interventions in arterial and venous thrombosis.
Acute coronary syndromes.
Atrial fibrillation.
Peripheral artery disease.
Antithrombotic drugs.
Disorders of coagulation in the neonate.
Hematologic changes in pregnancy.
Hematologic manifestations of childhood illness.
Hematologic manifestations of liver disease.
Hematologic manifestations of systemic disease: renal disease.
Hematologic manifestations of cancer.
Integrative therapies in patients with hematologic diseases.
Hematologic manifestations of HIV/AIDS.
Hematologic aspects of parasitic diseases.
Hematologic problems in the surgical patient: bleeding and thrombosis.
The spleen and its disorders.
Hematology in aging.
Resources for the hematologist: interpretive comments and selected reference values for neonatal, pediatric, and adult populations. Hematology, 6th Edition encompasses all of the latest scientific knowledge and clinical solutions in the field, equipping you with the expert answers you need to offer your patients the best possible outcomes. Ronald Hoffman, MD, Edward J. Benz, Jr., MD, Leslie E. Silberstein, MD, Helen Heslop, MD, Jeffrey Weitz, MD, John Anastasi, MD, and a host of world-class contributors present the expert, evidence-based guidance you need to make optimal use of the newest diagnostic and therapeutic options. Make confident, effective clinical decisions by consulting the world's most trusted hematology reference. Access the complete contents online at, with a downloadable image collection, regular updates, case studies, patient information sheets, and more.