Table of Contents

Section I. General principles.
Chapter 1. Drug invention and the pharmaceutical industry.
Chapter 2. Pharmacokinetics: the dynamics of drug absorption, distribution, metabolism, and elimination.
Chapter 3. Pharmacodynamics: molecular mechanisms of drug action.
Chapter 4. Drug toxicity and poisoning.
Chapter 5. Membrane transporters and drug response.
Chapter 6. Drug metabolism.
Chapter 7. Pharmacogenetics.
Section II. Neuropharmacology.
Chapter 8. Neurotransmission: the autonomic and somatic motor nervous systems.
Chapter 9. Muscarinic receptor agonists and antagonists.
Chapter 10. Anticholinesterase agents.
Chapter 11. Agents acting at the neuromuscular junction and autonomic ganglia.
Chapter 12. Adrenergic agonists and antagonists.
Chapter 13. 5-hydroxytryptamine (serotonin) and dopamine.
Chapter 14. Neurotransmission and the central nervous system.
Chapter 15. Drug therapy of depression and anxiety disorders.
Chapter 16. Pharmacotherapy of psychosis and mania.
Chapter 17. Hypnotics and sedatives.
Chapter 18. Opioids, analgesia, and pain management.
Chapter 19. General anesthetics and therapeutic gases.
Chapter 20. Local anesthetics.
Chapter 21. Pharmacotherapy of the epilepsies.
Chapter 22. Treatment of central nervous system degenerative disorders.
Chapter 23. Ethanol and methanol.
Chapter 24. Drug addiction.
Section III. Modulation of cardiovascular function.
Chapter 25. Regulation of renal function and vascular volume.
Chapter 26. Renin and angiotensin.
Chapter 27. Treatment of myocardial ischemia and hypertension.
Chapter 28. Pharmacotherapy of congestive heart failure.
Chapter 29. Anti-arrhythmic drugs.
Chapter 30. Blood coagulation and anticoagulant, fibrinolytic, and antiplatelet drugs.
Chapter 31. Drug therapy for hypercholesterolemia and dyslipidemia.
Section IV. Inflammation, immunomodulation, and hematopoiesis.
Chapter 32. Histamine, bradykinin, and their antagonists.
Chapter 33. Lipid-derived autacoids: eicosanoids and platelet-activating factor.
Chapter 34. Anti-inflammatory, antipyretic, and analgesic agents; pharmacotherapy of gout.
Chapter 35. Immunosuppressants, tolerogens, and immunostimulants.
Chapter 36. Pulmonary pharmacology.
Chapter 37. Hematopoietic agents: growth factors, minerals, and vitamins.
Section V. Hormones and hormone antagonists.
Chapter 38. Introduction to endocrinology: the hypothalamic-pituitary axis.
Chapter 39. Thyroid and anti-thyroid drugs.
Chapter 40. Estrogens and progestins.
Chapter 41. Androgens.
Chapter 42. Acth, adrenal steroids, and pharmacology of the adrenal cortex.
Chapter 43. Endocrine pancreas and pharmacotherapy of diabetes mellitus and hypoglycemia.
Chapter 44. Agents affecting mineral ion homeostasis and bone turnover.
Section VI. Drugs affecting gastrointestinal function.
Chapter 45. Pharmacotherapy of gastric acidity, peptic ulcers, and gastroesophageal reflux disease.
Chapter 46. Treatment of disorders of bowel motility and water flux; anti-emetics; agents used in biliary and pancreatic disease.
Chapter 47. Pharmacotherapy of inflammatory bowel disease.
Section VII. Chemotherapy of microbial diseases.
Chapter 48. General principles of antimicrobial therapy.
Chapter 49. Chemotherapy of malaria.
Chapter 50. Chemotherapy of protozoal infections: amebiasis, giardiasis, trichomoniasis, trypanosomiasis, leishmaniasis, and other protozoal infections.
Chapter 51. Chemotherapy of helminth infections.
Chapter 52. Sulfonamides, trimethoprim-sulfamethoxazole, quinolones, and agents for urinarytract infections.
Chapter 53. Penicillins, cephalosporins, and other β-lactam antibiotics.
Chapter 54. Aminoglycosides.
Chapter 55. Protein synthesis inhibitors and miscellaneous antibacterial agents.
Chapter 56. Chemotherapy of tuberculosis, mycobacterium avium complex disease, and leprosy.
Chapter 57. Antifungal agents.
Chapter 58. Antiviral agents (nonretroviral).
Chapter 59. Antiretroviral agents and treatment of hiv infection.
Section VIII. Chemotherapy of neoplastic diseases.
Chapter 60. General principles of cancer chemotherapy.
Chapter 61. Cytotoxic agents.
Chapter 62. Targeted therapies: tyrosine kinase inhibitors, monoclonal antibodies, and cytokines.
Chapter 63. Natural products in cancer chemotherapy: hormones and related agents.
Section IX. Special systems pharmacology.
Chapter 64. Ocular pharmacology.
Chapter 65. Dermatological pharmacology.
Chapter 66. Contraception and pharmacotherapy of obstetrical and gynecological disorders.
Chapter 67. Environmental toxicology: carcinogens and heavy metals.
Section X. Appendices.
Appendix i. Principles of prescription order writing and patient compliance.
Appendix ii. Design and optimization of dosage regimens: pharmacokinetic data. Goodman & Gilman's careful balance of basic science and clinical application has guided thousands of practitioners and students to a clear understanding of the drugs essential to preventing, diagnosing, and treating disease. Enriched by a new full-color presentation and updated to reflect all critical new developments in drug action and drug-disease interaction, the twelfth edition includes more than 440 color illustrations depicting key principles and actions of specific pathways and therapeutic agents. The companion DVD includes all the images and tables in the text along with narrated animations. More than a textbook, Goodman & Gilman's is a working template for the effective and rational prescribing of drugs in daily practice.