Terkko Navigator / Genes and Development

Guide RNA acrobatics: the one-for-two shuffle [Outlook]

Coupling crossover and synaptonemal complex in meiosis [Outlook]

The transcription factor activity gradient (TAG) model: contemplating a contact-independent mechanism for enhancer-promoter communication [Perspectives]

Functional interaction between the RNA exosome and the sirtuin deacetylase Hst3 maintains transcriptional homeostasis [Research Communications]

Functional rejuvenation of aged neural stem cells by Plagl2 and anti-Dyrk1a activity [Research Papers]

Transcription factor-mediated intestinal metaplasia and the role of a shadow enhancer [Research Papers]

The Zip4 protein directly couples meiotic crossover formation to synaptonemal complex assembly [Research Papers]

Guide RNA acrobatics: positioning consecutive uridines for pseudouridylation by H/ACA pseudouridylation loops with dual guide capacity [Research Papers]

Highly rigid H3.1/H3.2-H3K9me3 domains set a barrier for cell fate reprogramming in trophoblast stem cells [Research Papers]

Time is of the essence: the molecular mechanisms of primary microcephaly [Reviews]

Replication protein A associates with nucleolar R loops and regulates rRNA transcription and nucleolar morphology [Research Papers]

Widespread microRNA degradation elements in target mRNAs can assist the encoded proteins [Research Papers]

Distinct histone H3-H4 binding modes of sNASP reveal the basis for cooperation and competition of histone chaperones [Research Papers]

The evolution of metazoan shelterin [Research Papers]

A trivalent nucleosome interaction by PHIP/BRWD2 is disrupted in neurodevelopmental disorders and cancer [Research Papers]

TBX2 controls a proproliferative gene expression program in melanoma [Research Papers]

Recognition of acetylated histone by Yaf9 regulates metabolic cycling of transcription initiation and chromatin regulatory factors [Research Papers]

Corrigendum: In vivo CRISPR screening for phenotypic targets of the mir-35-42 family in C. elegans [Errata]

Reviewers, Volume 35 (2021) [Reviewers]

Unraveling the complexity of thermogenic remodeling of white fat reveals potential antiobesity therapies [Outlook]

Opening the window for endothelial-to-hematopoietic transition [Outlook]

Dissecting CTCF site function in a tense HoxD locus [Outlook]

Sentinels of chromatin: chromodomain helicase DNA-binding proteins in development and disease [Reviews]

Neural stem/precursor cells dynamically change their epigenetic landscape to differentially respond to BMP signaling for fate switching during brain development [Research Papers]

CEP120-mediated KIAA0753 recruitment onto centrioles is required for timely neuronal differentiation and germinal zone exit in the developing cerebellum [Research Papers]

ZFP423 controls EBF2 coactivator recruitment and PPAR{gamma} occupancy to determine the thermogenic plasticity of adipocytes [Research Papers]

Efficient hemogenic endothelial cell specification by RUNX1 is dependent on baseline chromatin accessibility of RUNX1-regulated TGF{beta} target genes [Research Papers]

Sequential in cis mutagenesis in vivo reveals various functions for CTCF sites at the mouse HoxD cluster [Research Papers]

Dynamics in Fip1 regulate eukaryotic mRNA 3' end processing [Research Papers]

Integrated loss- and gain-of-function screens define a core network governing human embryonic stem cell behavior [Resource/Methodology]

Corrigendum: Hepatocytes with extensive telomere deprotection and fusion remain viable and regenerate liver mass through endoreduplication [Errata]

Anticipating resistance to KRAS inhibition: a novel role for USP21 in macropinocytosis regulation [Outlook]

USP21 deubiquitinase elevates macropinocytosis to enable oncogenic KRAS bypass in pancreatic cancer [Research Communications]

Cold-responsive adipocyte progenitors couple adrenergic signaling to immune cell activation to promote beige adipocyte accrual [Research Communications]

Disruption of origin chromatin structure by helicase activation in the absence of DNA replication [Research Papers]

Role of 53BP1 in end protection and DNA synthesis at DNA breaks [Research Papers]

Vertebrate CTF18 and DDX11 essential function in cohesion is bypassed by preventing WAPL-mediated cohesin release [Research Papers]

Systematic functional characterization of antisense eRNA of protocadherin {alpha} composite enhancer [Research Papers]

Dissecting dual roles of MyoD during lineage conversion to mature myocytes and myogenic stem cells [Research Papers]

REST is a major negative regulator of endocrine differentiation during pancreas organogenesis [Research Papers]

Discovery of ciliary G protein-coupled receptors regulating pancreatic islet insulin and glucagon secretion [Research Papers]

Implications of inhibition of Rev1 interaction with Y family DNA polymerases for cisplatin chemotherapy [Research Papers]

The trans cell cycle effects of PARP inhibitors underlie their selectivity toward BRCA1/2-deficient cells [Research Papers]

Three-layered control of mRNA poly(A) tail synthesis in Saccharomyces cerevisiae [Research Papers]

Structural basis of PETISCO complex assembly during piRNA biogenesis in C. elegans [Research Papers]

Solving the chromosome puzzle of aneuploidy in cancer [Outlook]

BMAL1 dephosphorylation determines the pace of the circadian clock [Outlook]

Clonal selection of stable aneuploidies in progenitor cells drives high-prevalence tumorigenesis [Research Papers]

Transient genomic instability drives tumorigenesis through accelerated clonal evolution [Research Papers]

miR-200 deficiency promotes lung cancer metastasis by activating Notch signaling in cancer-associated fibroblasts [Research Papers]