Terkko Navigator / Genes and Development

Top1 and Top2 promote replication fork arrest at a programmed pause site [Outlook]

Linking cancer transcriptional addictions by CDK7 to YAP/TAZ [Outlook]

53BP1: a DSB escort [Reviews]

Genomic imprinting in plants--revisiting existing models [Reviews]

Muscle-derived Dpp regulates feeding initiation via endocrine modulation of brain dopamine biosynthesis [Research Papers]

CDK7 regulates organ size and tumor growth by safeguarding the Hippo pathway effector Yki/Yap/Taz in the nucleus [Research Papers]

Induction of AP-1 by YAP/TAZ contributes to cell proliferation and organ growth [Research Papers]

Fork pausing complex engages topoisomerases at the replisome [Research Papers]

Set1/COMPASS repels heterochromatin invasion at euchromatic sites by disrupting Suv39/Clr4 activity and nucleosome stability [Research Papers]

Control of noncoding RNA production and histone levels by a 5' tRNA fragment [Research Papers]

A unified allosteric/torpedo mechanism for transcriptional termination on human protein-coding genes [Research Papers]

Corrigendum: DNA polymerase {theta} accomplishes translesion synthesis opposite 1,N6-ethenodeoxyadenosine with a remarkably high fidelity in human cells [Errata]

Mixed ubiquitin chains regulate DNA repair [Outlook]

The human nucleolus organizer regions [Outlook]

Evaluating phase separation in live cells: diagnosis, caveats, and functional consequences [Perspectives]

Cell-type-specific dysregulation of RNA alternative splicing in short tandem repeat mouse knockin models of myotonic dystrophy [Research Communications]

Dual functions of angiopoietin-like protein 2 signaling in tumor progression and anti-tumor immunity [Research Papers]

Activation of invariant natural killer T cells stimulates adipose tissue remodeling via adipocyte death and birth in obesity [Research Papers]

Context-specific regulation of cell survival by a miRNA-controlled BIM rheostat [Research Papers]

Human NORs, comprising rDNA arrays and functionally conserved distal elements, are located within dynamic chromosomal regions [Research Papers]

Crosstalk between Lys63- and Lys11-polyubiquitin signaling at DNA damage sites is driven by Cezanne [Research Papers]

The KDM5A/RBP2 histone demethylase represses NOTCH signaling to sustain neuroendocrine differentiation and promote small cell lung cancer tumorigenesis [Research Papers]

Paralytic, the Drosophila voltage-gated sodium channel, regulates proliferation of neural progenitors [Research Papers]

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity [Resource/Methodology]

Reviewers, Volume 33 (2019) [Reviewers]

Hippo signaling does it again: arbitrating cardiac fibroblast identity and activation [Outlook]

Metabolic dependencies and vulnerabilities in leukemia [Reviews]

Human stem cell models: lessons for pancreatic development and disease [Reviews]

Hippo pathway deletion in adult resting cardiac fibroblasts initiates a cell state transition with spontaneous and self-sustaining fibrosis [Research Papers]

Structural basis for distinct roles of SMAD2 and SMAD3 in FOXH1 pioneer-directed TGF-{beta} signaling [Research Papers]

The Integrator complex cleaves nascent mRNAs to attenuate transcription [Research Papers]

Checkpoint inhibition of origin firing prevents DNA topological stress [Research Papers]

Termination of pre-mRNA splicing requires that the ATPase and RNA unwindase Prp43p acts on the catalytic snRNA U6 [Research Papers]

Planarians recruit piRNAs for mRNA turnover in adult stem cells [Research Papers]

Hi-C guided assemblies reveal conserved regulatory topologies on X and autosomes despite extensive genome shuffling [Resource Methodology]

Erratum: Single-nucleus transcriptomic survey of cell diversity and functional maturation in postnatal mammalian hearts [Errata]

Erratum: Dedifferentiation by adenovirus E1A due to inactivation of Hippo pathway effectors YAP and TAZ [Errata]

Ways to unwind with HROB, a new player in homologous recombination [Outlook]

Melanoma plasticity and phenotypic diversity: therapeutic barriers and opportunities [Reviews]

Kidney organoids: accurate models or fortunate accidents [Reviews]

Intricate SUMO-based control of the homologous recombination machinery [Reviews]

Molecular basis for GIGYF-Me31B complex assembly in 4EHP-mediated translational repression [Research Communications]

USP21 deubiquitinase promotes pancreas cancer cell stemness via Wnt pathway activation [Research Communications]

miR-26 suppresses adipocyte progenitor differentiation and fat production by targeting Fbxl19 [Research Papers]

ZCCHC8, the nuclear exosome targeting component, is mutated in familial pulmonary fibrosis and is required for telomerase RNA maturation [Research Papers]

Control of homologous recombination by the HROB-MCM8-MCM9 pathway [Research Papers]

Regulation of histone methylation by automethylation of PRC2 [Research Papers]

Automethylation of PRC2 promotes H3K27 methylation and is impaired in H3K27M pediatric glioma [Research Papers]

An improved auxin-inducible degron system preserves native protein levels and enables rapid and specific protein depletion [Resource/Methodology]

Nxf3: a middleman with the right connections for unspliced piRNA precursor export [Outlook]