Terkko Navigator / Gene Therapy

Delivering cellular and gene therapies to patients: solutions for realizing the potential of the next generation of medicine

Reviewer recognition

Cell therapy for Parkinson′s disease is coming of age: current challenges and future prospects with a focus on immunomodulation

Astrocyte-selective AAV gene therapy through the endogenous GFAP promoter results in robust transduction in the rat spinal cord following injury

Polarized AAVR expression determines infectivity by AAV gene therapy vectors

Regulated ex vivo regional gene therapy for bone repair using an inducible caspase-9 suicide gene system

Adeno-associated virus neutralising antibodies in type 1 diabetes mellitus

Magic realism: a Latin American paradigm for stem cell research & development?

Inhibition of microRNA-495 suppresses chondrocyte apoptosis through activation of the NF-κB signaling pathway by regulating CCL4 in osteoarthritis

Stability of the adeno-associated virus 8 reference standard material

Combination of cabazitaxel and p53 gene therapy abolishes prostate carcinoma tumor growth

Safe and neuroprotective vectors for long-term traumatic brain injury gene therapy

A novel xenograft mouse model for testing approaches targeting human kappa light-chain diseases

A novel approach for assessment of prostate cancer aggressiveness using survivin-driven tumour-activatable minicircles

Combination of cytokine-enhanced vaccine and chemo-gene therapy as surgery adjuvant treatments for spontaneous canine melanoma

Gene and cell therapy on the acquisition and relapse-like binge drinking in a model of alcoholism: translational options

ILK promotes survival and self-renewal of hypoxic MSCs via the activation of lncTCF7-Wnt pathway induced by IL-6/STAT3 signaling

scFv6.C4 DNA vaccine with fragment C of Tetanus toxin increases protective immunity against CEA-expressing tumor

Regulatable adenovector harboring the GFP and Yamanaka genes for implementing regenerative medicine in the brain

Measles vector as a multiple genes delivery platform facilitating iPSC reprogramming

Helper-dependent adenovirus-mediated gene transfer of a secreted LDL receptor/transferrin chimeric protein reduces aortic atherosclerosis in LDL receptor-deficient mice

Factors governing the transduction efficiency of adeno-associated virus in the retinal ganglion cells following intravitreal injection

Safety and efficacy evaluations of an adeno-associated virus variant for preparing IL10-secreting human neural stem cell-based therapeutics

Dual-targeted NIS polyplexes—a theranostic strategy toward tumors with heterogeneous receptor expression

Production of lentiviral vectors using novel, enzymatically produced, linear DNA

Correction: Epistasis between Pax6Sey and genetic background reinforces the value of defined hybrid mouse models for therapeutic trials

Histone deacetylase inhibitors reactivate silenced transgene in vivo

GDNF-mediated rescue of the nigrostriatal system depends on the degree of degeneration

Immunosuppression overcomes insulin- and vector-specific immune responses that limit efficacy of AAV2/8-mediated insulin gene therapy in NOD mice

Reviewer recognition

Unilateral ex vivo gene therapy by GDNF in epileptic rats

HIV infection alters the human epigenetic landscape

Comparative efficacy of dermal fibroblast-mediated and direct adenoviral bone morphogenetic protein-2 gene therapy for bone regeneration in an equine rib model

Gene therapy progress and prospects: synthetic polymer-based systems

The radiation-inducible pE9 promoter driving inducible nitric oxide synthase radiosensitizes hypoxic tumour cells to radiation

Correction of a genetic defect in multipotent germline stem cells using a human artificial chromosome

Expression and maturation of Sendai virus vector-derived CFTR protein: functional and biochemical evidence using a GFP-CFTR fusion protein

Topical matrix-based siRNA silences local gene expression in a murine wound model

Complete knockdown of CCR5 by lentiviral vector-expressed siRNAs and protection of transgenic macrophages against HIV-1 infection

Human neural stem cells target and deliver therapeutic gene to experimental leptomeningeal medulloblastoma

Biocompatible micellar nanovectors achieve efficient gene transfer to vascular lesions without cytotoxicity and thrombus formation

In vivo gene silencing in solid tumors by targeted electrically mediated siRNA delivery