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AddAla-Kokko, T(ero)
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AddAntikainen, R.
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AddKettunen, J(ohannes)
AddKietzmann, T(homas).
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AddKnuuttila, M.
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Substrate specificity and conformational flexibility properties of the Mycobacterium tuberculosisβ-oxidation trifunctional enzymeWierenga, R.K.159 dayssaveRefWorksSFX Info
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IceBear: an intuitive and versatile web application for research-data tracking from crystallization experiment to PDB depositionWierenga, R.K.263 dayssaveRefWorksSFX Info
Structure of transmembrane prolyl 4-hydroxylase reveals unique organization of EF and dioxygenase domainsWierenga, R.K.263 dayssaveRefWorksSFX Info
Crystallographic binding studies of rat peroxisomal multifunctional enzyme type 1 with 3-ketodecanoyl-CoA: capturing active and inactive states of its hydratase and dehydrogenase catalytic sitesWierenga, R.K.263 dayssaveRefWorksSFX Info
Insights into the stability and substrate specificity of the E. coli aerobicβ-oxidation trifunctional enzyme complexWierenga, R.K.263 dayssaveRefWorksSFX Info
Mutation update on ACAT1 variants associated with mitochondrial acetoacetyl-CoA thiolase (T2) deficiencyWierenga, R.K.263 dayssaveRefWorksSFX Info
Complementary substrate specificity and distinct quaternary assembly of the <em>Escherichia coli</em> aerobic and anaerobicβ-oxidation trifunctional enzyme complexesWierenga, R.K.263 dayssaveRefWorksSFX Info
The peroxisomal zebrafish SCP2-thiolase (type-1) is a weak transient dimer as revealed by crystal structures and native mass spectrometryWierenga, R.K.263 dayssaveRefWorksSFX Info
Structural enzymology binding studies of the peptide-substrate-binding domain of human collagen prolyl 4-hydroxylase (type-II): High affinity peptides have a PxGP sequence motifWierenga, R.K.263 dayssaveRefWorksSFX Info
Crystal structure of human anterior gradient protein 3Wierenga, R.K.263 dayssaveRefWorksSFX Info
De novo biosynthesis of sterols and fatty acids in the Trypanosoma brucei procyclic form: Carbon source preferences and metabolic flux redistributionsWierenga, R.K.263 dayssaveRefWorksSFX Info
Structural enzymology comparisons of multifunctional enzyme, type-1 (MFE1): the flexibility of its dehydrogenase partWierenga, R.K.263 dayssaveRefWorksSFX Info
Assembly of the elongated collagen prolyl 4-hydroxylaseα<sub>2</sub>β<sub>2</sub> heterotetramer around a central α<sub>2</sub> dimerWierenga, R.K.263 dayssaveRefWorksSFX Info
Crystallographic substrate binding studies of Leishmania mexicana SCP2-thiolase (type-2): unique features of oxyanion hole-1Wierenga, R.K.263 dayssaveRefWorksSFX Info
Crystal structure of a thiolase from Escherichia coli at 1.8 Å resolutionWierenga, R.K.263 dayssaveRefWorksSFX Info
Crystal structures of two monomeric triosephosphate isomerase variants identified via a directed-evolution protocol selecting for L-arabinose isomerase activityWierenga, R.K.263 dayssaveRefWorksSFX Info
Structure-Function Studies of Hydrophobic Residues That Clamp a Basic Glutamate Side Chain during Catalysis by Triosephosphate IsomeraseWierenga, R.K.263 dayssaveRefWorksSFX Info
The SCP2-thiolase-like protein (SLP) of Trypanosoma brucei is an enzyme involved in lipid metabolismWierenga, R.K.263 dayssaveRefWorksSFX Info
The extended structure of the periplasmic region of CdsD, a structural protein of the type III secretion system of Chlamydia trachomatisWierenga, R.K.263 dayssaveRefWorksSFX Info
Structural characterization of a mitochondrial 3-ketoacyl-CoA (T1)-like thiolase from Mycobacterium smegmatisWierenga, R.K.263 dayssaveRefWorksSFX Info
Structures of yeast peroxisomalΔ(3),Δ(2)-enoyl-CoA isomerase complexed with acyl-CoA substrate analogues: the importance of hydrogen-bond networks for the reactivity of the catalytic base and the oxyanion holeWierenga, R.K.263 dayssaveRefWorksSFX Info
ATGme: Open-source web application for rare codon identification and custom DNA sequence optimizationWierenga, R.K.263 dayssaveRefWorksSFX Info
Structure-based directed evolution of a monomeric triosephosphate isomerase: toward a pentose sugar isomeraseWierenga, R.K.263 dayssaveRefWorksSFX Info
HumanΔ³,Δ²-enoyl-CoA isomerase, type 2: a structural enzymology study on the catalytic role of its ACBP domain and helix-10Wierenga, R.K.263 dayssaveRefWorksSFX Info
The crystal structure of human mitochondrial 3-ketoacyl-CoA thiolase (T1): insight into the reaction mechanism of its thiolase and thioesterase activitiesWierenga, R.K.263 dayssaveRefWorksSFX Info
Crystallization and preliminary X-ray diffraction studies of the C-terminal domain of Chlamydia trachomatis CdsDWierenga, R.K.263 dayssaveRefWorksSFX Info
Insights into mitochondrial fatty acid synthesis from the structure of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA dehydrogenaseWierenga, R.K.263 dayssaveRefWorksSFX Info
Phylogenetic relationships and classification of thiolases and thiolase-like proteins of Mycobacterium tuberculosis and Mycobacterium smegmatisWierenga, R.K.263 dayssaveRefWorksSFX Info
A comprehensive analysis of the geranylgeranylglyceryl phosphate synthase enzyme family identifies novel members and reveals mechanisms of substrate specificity and quaternary structure organizationWierenga, R.K.263 dayssaveRefWorksSFX Info
The structural motifs for substrate binding and dimerization of theα subunit of collagen prolyl 4-hydroxylaseWierenga, R.K.263 dayssaveRefWorksSFX Info
Development of MLPA for human ACAT1 gene and identification of a heterozygous Alu-mediated deletion of exons 3 and 4 in a patient with mitochondrial acetoacetyl-CoA thiolase (T2) deficiencyWierenga, R.K.263 dayssaveRefWorksSFX Info
Structural mutations that probe the interactions between the catalytic and dianion activation sites of triosephosphate isomeraseWierenga, R.K.263 dayssaveRefWorksSFX Info
Crystal structures of SCP2-thiolases of Trypanosomatidae, human pathogens causing widespread tropical diseases: the importance for catalysis of the cysteine of the unique HDCF loopWierenga, R.K.263 dayssaveRefWorksSFX Info
Structure of mycobacterialβ-oxidation trifunctional enzyme reveals its altered assembly and putative substrate channeling pathwayWierenga, R.K.263 dayssaveRefWorksSFX Info
Three Japanese Patients with Beta-Ketothiolase Deficiency Who Share a Mutation, c.431A&gt;C (H144P) in ACAT1 : Subtle Abnormality in Urinary Organic Acid Analysis and Blood Acylcarnitine Analysis Using Tandem Mass SpectrometryWierenga, R.K.263 dayssaveRefWorksSFX Info
The isomerase and hydratase reaction mechanism of the crotonase active site of the multifunctional enzyme (type-1), as deduced from structures of complexes with 3S-hydroxy-acyl-CoAWierenga, R.K.263 dayssaveRefWorksSFX Info
Crystal structure of a monomeric thiolase-like protein type 1 (TLP1) from Mycobacterium smegmatisWierenga, R.K.263 dayssaveRefWorksSFX Info
The enolization chemistry of a thioester-dependent racemase: the 1.4Å crystal structure of a reaction intermediate complex characterized by detailed QM/MM calculationsWierenga, R.K.263 dayssaveRefWorksSFX Info
The characterization and evolutionary relationships of a trypanosomal thiolaseWierenga, R.K.263 dayssaveRefWorksSFX Info
Cloning, expression, purification and preliminary X-ray diffraction studies of a putative Mycobacterium smegmatis thiolaseWierenga, R.K.263 dayssaveRefWorksSFX Info
High resolution crystal structures of triosephosphate isomerase complexed with its suicide inhibitors: the conformational flexibility of the catalytic glutamate in its closed, liganded active siteWierenga, R.K.263 dayssaveRefWorksSFX Info
Stereoelectronic requirements for optimal hydrogen-bond-catalyzed enolizationWierenga, R.K.263 dayssaveRefWorksSFX Info
Triosephosphate isomerase: a highly evolved biocatalystWierenga, R.K.263 dayssaveRefWorksSFX Info
Crystallographic binding studies with an engineered monomeric variant of triosephosphate isomeraseWierenga, R.K.263 dayssaveRefWorksSFX Info
Crystal structure of liganded rat peroxisomal multifunctional enzyme type 1: a flexible molecule with two interconnected active sitesWierenga, R.K.263 dayssaveRefWorksSFX Info
Atomic resolution crystallography of a complex of triosephosphate isomerase with a reaction-intermediate analog: new insight in the proton transfer reaction mechanismWierenga, R.K.263 dayssaveRefWorksSFX Info
The thiolase reaction mechanism: the importance of Asn316 and His348 for stabilizing the enolate intermediate of the Claisen condensationWierenga, R.K.263 dayssaveRefWorksSFX Info
Mitochondrial fatty acid synthesis--an adopted set of enzymes making a pathway of major importance for the cellular metabolismWierenga, R.K.263 dayssaveRefWorksSFX Info
17beta-hydroxysteroid dehydrogenase type 8 and carbonyl reductase type 4 assemble as a ketoacyl reductase of human mitochondrial FASWierenga, R.K.263 dayssaveRefWorksSFX Info
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