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Substrate specificity and conformational flexibility properties of the Mycobacterium tuberculosisβ-oxidation trifunctional enzymeWierenga, R.K.69 dayssaveRefWorksSFX Info
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IceBear: an intuitive and versatile web application for research-data tracking from crystallization experiment to PDB depositionWierenga, R.K.173 dayssaveRefWorksSFX Info
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Crystallographic binding studies of rat peroxisomal multifunctional enzyme type 1 with 3-ketodecanoyl-CoA: capturing active and inactive states of its hydratase and dehydrogenase catalytic sitesWierenga, R.K.173 dayssaveRefWorksSFX Info
Insights into the stability and substrate specificity of the E. coli aerobicβ-oxidation trifunctional enzyme complexWierenga, R.K.173 dayssaveRefWorksSFX Info
Mutation update on ACAT1 variants associated with mitochondrial acetoacetyl-CoA thiolase (T2) deficiencyWierenga, R.K.173 dayssaveRefWorksSFX Info
Complementary substrate specificity and distinct quaternary assembly of the <em>Escherichia coli</em> aerobic and anaerobicβ-oxidation trifunctional enzyme complexesWierenga, R.K.173 dayssaveRefWorksSFX Info
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Structural enzymology binding studies of the peptide-substrate-binding domain of human collagen prolyl 4-hydroxylase (type-II): High affinity peptides have a PxGP sequence motifWierenga, R.K.173 dayssaveRefWorksSFX Info
Crystal structure of human anterior gradient protein 3Wierenga, R.K.173 dayssaveRefWorksSFX Info
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Structural enzymology comparisons of multifunctional enzyme, type-1 (MFE1): the flexibility of its dehydrogenase partWierenga, R.K.173 dayssaveRefWorksSFX Info
Assembly of the elongated collagen prolyl 4-hydroxylaseα<sub>2</sub>β<sub>2</sub> heterotetramer around a central α<sub>2</sub> dimerWierenga, R.K.173 dayssaveRefWorksSFX Info
Crystallographic substrate binding studies of Leishmania mexicana SCP2-thiolase (type-2): unique features of oxyanion hole-1Wierenga, R.K.173 dayssaveRefWorksSFX Info
Crystal structure of a thiolase from Escherichia coli at 1.8 Å resolutionWierenga, R.K.173 dayssaveRefWorksSFX Info
Crystal structures of two monomeric triosephosphate isomerase variants identified via a directed-evolution protocol selecting for L-arabinose isomerase activityWierenga, R.K.173 dayssaveRefWorksSFX Info
Structure-Function Studies of Hydrophobic Residues That Clamp a Basic Glutamate Side Chain during Catalysis by Triosephosphate IsomeraseWierenga, R.K.173 dayssaveRefWorksSFX Info
The SCP2-thiolase-like protein (SLP) of Trypanosoma brucei is an enzyme involved in lipid metabolismWierenga, R.K.173 dayssaveRefWorksSFX Info
The extended structure of the periplasmic region of CdsD, a structural protein of the type III secretion system of Chlamydia trachomatisWierenga, R.K.173 dayssaveRefWorksSFX Info
Structural characterization of a mitochondrial 3-ketoacyl-CoA (T1)-like thiolase from Mycobacterium smegmatisWierenga, R.K.173 dayssaveRefWorksSFX Info
Structures of yeast peroxisomalΔ(3),Δ(2)-enoyl-CoA isomerase complexed with acyl-CoA substrate analogues: the importance of hydrogen-bond networks for the reactivity of the catalytic base and the oxyanion holeWierenga, R.K.173 dayssaveRefWorksSFX Info
ATGme: Open-source web application for rare codon identification and custom DNA sequence optimizationWierenga, R.K.173 dayssaveRefWorksSFX Info
Structure-based directed evolution of a monomeric triosephosphate isomerase: toward a pentose sugar isomeraseWierenga, R.K.173 dayssaveRefWorksSFX Info
HumanΔ³,Δ²-enoyl-CoA isomerase, type 2: a structural enzymology study on the catalytic role of its ACBP domain and helix-10Wierenga, R.K.173 dayssaveRefWorksSFX Info
The crystal structure of human mitochondrial 3-ketoacyl-CoA thiolase (T1): insight into the reaction mechanism of its thiolase and thioesterase activitiesWierenga, R.K.173 dayssaveRefWorksSFX Info
Crystallization and preliminary X-ray diffraction studies of the C-terminal domain of Chlamydia trachomatis CdsDWierenga, R.K.173 dayssaveRefWorksSFX Info
Insights into mitochondrial fatty acid synthesis from the structure of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA dehydrogenaseWierenga, R.K.173 dayssaveRefWorksSFX Info
Phylogenetic relationships and classification of thiolases and thiolase-like proteins of Mycobacterium tuberculosis and Mycobacterium smegmatisWierenga, R.K.173 dayssaveRefWorksSFX Info
A comprehensive analysis of the geranylgeranylglyceryl phosphate synthase enzyme family identifies novel members and reveals mechanisms of substrate specificity and quaternary structure organizationWierenga, R.K.173 dayssaveRefWorksSFX Info
The structural motifs for substrate binding and dimerization of theα subunit of collagen prolyl 4-hydroxylaseWierenga, R.K.173 dayssaveRefWorksSFX Info
Development of MLPA for human ACAT1 gene and identification of a heterozygous Alu-mediated deletion of exons 3 and 4 in a patient with mitochondrial acetoacetyl-CoA thiolase (T2) deficiencyWierenga, R.K.173 dayssaveRefWorksSFX Info
Structural mutations that probe the interactions between the catalytic and dianion activation sites of triosephosphate isomeraseWierenga, R.K.173 dayssaveRefWorksSFX Info
Crystal structures of SCP2-thiolases of Trypanosomatidae, human pathogens causing widespread tropical diseases: the importance for catalysis of the cysteine of the unique HDCF loopWierenga, R.K.173 dayssaveRefWorksSFX Info
Structure of mycobacterialβ-oxidation trifunctional enzyme reveals its altered assembly and putative substrate channeling pathwayWierenga, R.K.173 dayssaveRefWorksSFX Info
Three Japanese Patients with Beta-Ketothiolase Deficiency Who Share a Mutation, c.431A&gt;C (H144P) in ACAT1 : Subtle Abnormality in Urinary Organic Acid Analysis and Blood Acylcarnitine Analysis Using Tandem Mass SpectrometryWierenga, R.K.173 dayssaveRefWorksSFX Info
The isomerase and hydratase reaction mechanism of the crotonase active site of the multifunctional enzyme (type-1), as deduced from structures of complexes with 3S-hydroxy-acyl-CoAWierenga, R.K.173 dayssaveRefWorksSFX Info
Crystal structure of a monomeric thiolase-like protein type 1 (TLP1) from Mycobacterium smegmatisWierenga, R.K.173 dayssaveRefWorksSFX Info
The enolization chemistry of a thioester-dependent racemase: the 1.4Å crystal structure of a reaction intermediate complex characterized by detailed QM/MM calculationsWierenga, R.K.173 dayssaveRefWorksSFX Info
The characterization and evolutionary relationships of a trypanosomal thiolaseWierenga, R.K.173 dayssaveRefWorksSFX Info
Cloning, expression, purification and preliminary X-ray diffraction studies of a putative Mycobacterium smegmatis thiolaseWierenga, R.K.173 dayssaveRefWorksSFX Info
High resolution crystal structures of triosephosphate isomerase complexed with its suicide inhibitors: the conformational flexibility of the catalytic glutamate in its closed, liganded active siteWierenga, R.K.173 dayssaveRefWorksSFX Info
Stereoelectronic requirements for optimal hydrogen-bond-catalyzed enolizationWierenga, R.K.173 dayssaveRefWorksSFX Info
Triosephosphate isomerase: a highly evolved biocatalystWierenga, R.K.173 dayssaveRefWorksSFX Info
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Crystal structure of liganded rat peroxisomal multifunctional enzyme type 1: a flexible molecule with two interconnected active sitesWierenga, R.K.173 dayssaveRefWorksSFX Info
Atomic resolution crystallography of a complex of triosephosphate isomerase with a reaction-intermediate analog: new insight in the proton transfer reaction mechanismWierenga, R.K.173 dayssaveRefWorksSFX Info
The thiolase reaction mechanism: the importance of Asn316 and His348 for stabilizing the enolate intermediate of the Claisen condensationWierenga, R.K.173 dayssaveRefWorksSFX Info
Mitochondrial fatty acid synthesis--an adopted set of enzymes making a pathway of major importance for the cellular metabolismWierenga, R.K.173 dayssaveRefWorksSFX Info
17beta-hydroxysteroid dehydrogenase type 8 and carbonyl reductase type 4 assemble as a ketoacyl reductase of human mitochondrial FASWierenga, R.K.173 dayssaveRefWorksSFX Info
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