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Activation of nuclear receptor PXR induces atherogenic lipids and PCSK9 through SREBP2-mediated mechanismHakkola, J.31 dayssaveRefWorksSFX Info
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Regulation of hepatic energy metabolism by the nuclear receptor PXRHakkola, J.46 dayssaveRefWorksSFX Info
Hypoxia-Inducible Factor Prolyl 4-Hydroxylase-2 Inhibition Protects Against Development of AtherosclerosisHakkola, J.46 dayssaveRefWorksSFX Info
The effect of pregnane X receptor agonists on postprandial incretin hormone secretion in rats and humansHakkola, J.46 dayssaveRefWorksSFX Info
Tumour suppressor protein p53 regulates the stress activated bilirubin oxidase cytochrome P450 2A6Hakkola, J.46 dayssaveRefWorksSFX Info
Sodium valproate induces mitochondrial respiration dysfunction in HepG2 in vitro cell modelHakkola, J.46 dayssaveRefWorksSFX Info
Reactive metabolites in early drug development: predictive in vitro toolsHakkola, J.46 dayssaveRefWorksSFX Info
SIRT5 is under the control of PGC-1α and AMPK and is involved in regulation of mitochondrial energy metabolismHakkola, J.46 dayssaveRefWorksSFX Info
Metformin induces PGC-1α expression and selectively affects hepatic PGC-1α functionsHakkola, J.46 dayssaveRefWorksSFX Info
Pregnane X receptor (PXR)--a contributor to the diabetes epidemic?Hakkola, J.46 dayssaveRefWorksSFX Info
Pregnane X receptor agonists impair postprandial glucose toleranceHakkola, J.46 dayssaveRefWorksSFX Info
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Heme and heme biosynthesis intermediates induce heme oxygenase-1 and cytochrome P450 2A5, enzymes with putative sequential roles in heme and bilirubin metabolism: different requirement for transcription factor nuclear factor erythroid- derived 2-likeHakkola, J.46 dayssaveRefWorksSFX Info
Preservation, induction or incorporation of metabolism into the in vitro cellular system - views to current opportunities and limitationsHakkola, J.46 dayssaveRefWorksSFX Info
Function and regulation of the Cyp2a5/CYP2A6 genes in response to toxic insults in the liverHakkola, J.46 dayssaveRefWorksSFX Info
Characterization of human cytochrome P450 induction by pesticidesHakkola, J.46 dayssaveRefWorksSFX Info
Energy-sensing factors coactivator peroxisome proliferator-activated receptorγ coactivator 1-α (PGC-1α) and AMP-activated protein kinase control expression of inflammatory mediators in liver: induction of interleukin 1 receptor antagonistHakkola, J.46 dayssaveRefWorksSFX Info
Energy sensing factors PGC-1α and SIRT1 modulate PXR expression and functionHakkola, J.46 dayssaveRefWorksSFX Info
Metabolism of ophthalmic timolol: new aspects of an old drugHakkola, J.46 dayssaveRefWorksSFX Info
Cytochrome P450-mediated pulmonary metabolism of carcinogens: regulation and cross-talk in lung carcinogenesisHakkola, J.46 dayssaveRefWorksSFX Info
Cytochrome P450 2A5 constitutive expression and induction by heavy metals is dependent on redox-sensitive transcription factor Nrf2 in liverHakkola, J.46 dayssaveRefWorksSFX Info
Effects of selective serotonin reuptake inhibitors on timolol metabolism in human liver microsomes and cryo-preserved hepatocytesHakkola, J.46 dayssaveRefWorksSFX Info
Expression of cytochrome P450 (CYP) enzymes in human nonpigmented ciliary epithelial cells: induction of CYP1B1 expression by TCDDHakkola, J.46 dayssaveRefWorksSFX Info
Cytochromes P450, induction and cholesterol--what are the connections?Hakkola, J.46 dayssaveRefWorksSFX Info
Inhibition and induction of human cytochrome P450 enzymes: current statusHakkola, J.46 dayssaveRefWorksSFX Info
Coactivator PGC-1alpha regulates the fasting inducible xenobiotic-metabolizing enzyme CYP2A5 in mouse primary hepatocytesHakkola, J.46 dayssaveRefWorksSFX Info
Influence of adenosine triphosphate and ABCB1 (MDR1) genotype on the P-glycoprotein-dependent transfer of saquinavir in the dually perfused human placentaHakkola, J.46 dayssaveRefWorksSFX Info
Microarray analysis of the global alterations in the gene expression in the placentas from cigarette-smoking mothersHakkola, J.46 dayssaveRefWorksSFX Info
Transcription factor binding to a putative double E-box motif represses CYP3A4 expression in human lung cellsHakkola, J.46 dayssaveRefWorksSFX Info
Aryl hydrocarbon receptor nuclear translocator and upstream stimulatory factor regulate Cytochrome P450 2a5 transcription through a common E-box siteHakkola, J.46 dayssaveRefWorksSFX Info
Regulation of CYP2A5 gene by the transcription factor nuclear factor (erythroid-derived 2)-like 2Hakkola, J.46 dayssaveRefWorksSFX Info
Placental transfer of quetiapine in relation to P-glycoprotein activityHakkola, J.46 dayssaveRefWorksSFX Info
Characterization of androgen-regulated expression of CYP3A5 in human prostateHakkola, J.46 dayssaveRefWorksSFX Info
Functional role of P-glycoprotein in the human blood-placental barrierHakkola, J.46 dayssaveRefWorksSFX Info
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