Table of Contents
Introduction / Michael J Barratt, Donald E Frail.
Drug Repositioning: Business Case, Strategies, and Operational Considerations. Drug Repositioning: The Business Case and Current Strategies to Repurpose Shelved Candidates and Marketed Drugs / John Arrowsmith, Richard Harrison.
Opportunities and Challenges Associated with Developing Additional Indications for Clinical Development Candidates and Marketed Drugs / Donald E Frail, Michael J Barratt.
Clinical and Operational Considerations in Repositioning Marketed Drugs and Drug Candidates / Damian O'connell, David J Sequeira, Maria L Miller.
Regulatory Considerations and Strategies for Drug Repositioning / Ken Phelps.
Application of Technology Platforms to Uncover New Indications and Repurpose Existing Drugs. Computational and Bioinformatic Strategies for Drug Repositioning / Richard Mazzarella, Craig Webb.
Mining Scientific and Clinical Databases to Identify Novel Uses for Existing Drugs / Christos Andronis, Anuj Sharma, Spyros Deftereos, Vassilis Virvilis, Ourania Konstanti, Andreas Persidis, Aris Persidis.
Predicting the Polypharmacology of Drugs: Identifying New Uses through Chemoinformatics, Structural Informatics, and Molecular Modeling-Based Approaches / Li Xie, Sarah L Kinnings, Lei Xie, Philip E Bourne.
Systematic Phenotypic Screening for Novel Synergistic Combinations: A New Paradigm for Repositioning Existing Drugs / Margaret S Lee.
Phenotypic Screening to Identify New, Unpredicted Indications for Existing Drugs and Drug Candidates / Michael S Saporito, Christopher A Lipinski, Andrew G Reaume.
Old Drugs Yield New Discoveries: Examples from the Prodrug, Chiral Switch, and Site-Selective Deuteration Strategies / Adam J Morgan, Bhaumik A Pandya, Craig E Masse, Scott L Harbeson.
Academic and Nonprofit Initiatives and the Role of Alliances in the Drug Repositioning Industry. Repurposing Drugs for Tropical Diseases: Case Studies and Open-Source Screening Initiatives / Curtis R Chong.
Drug Repositioning Efforts by Nonprofit Foundations / Donald E Frail, Louis Degennaro, Aaron Schimmer, James Kasper, Richard Winneker, Todd B Sherer, Alison Urkowitz, Kuldip D Dave, Jill Panetta, John McCall.
Business Development Strategies in the Repositioning Industry / Aris Persidis, Elizabeth T Stark.
A Case Study in Drug Repositioning: Sosei / Akinori Mochizuki, Makiko Aoyama.
Appendix: Additional Drug Repositioning Resources and Links.
Index.
Drug Repositioning: Business Case, Strategies, and Operational Considerations. Drug Repositioning: The Business Case and Current Strategies to Repurpose Shelved Candidates and Marketed Drugs / John Arrowsmith, Richard Harrison.
Opportunities and Challenges Associated with Developing Additional Indications for Clinical Development Candidates and Marketed Drugs / Donald E Frail, Michael J Barratt.
Clinical and Operational Considerations in Repositioning Marketed Drugs and Drug Candidates / Damian O'connell, David J Sequeira, Maria L Miller.
Regulatory Considerations and Strategies for Drug Repositioning / Ken Phelps.
Application of Technology Platforms to Uncover New Indications and Repurpose Existing Drugs. Computational and Bioinformatic Strategies for Drug Repositioning / Richard Mazzarella, Craig Webb.
Mining Scientific and Clinical Databases to Identify Novel Uses for Existing Drugs / Christos Andronis, Anuj Sharma, Spyros Deftereos, Vassilis Virvilis, Ourania Konstanti, Andreas Persidis, Aris Persidis.
Predicting the Polypharmacology of Drugs: Identifying New Uses through Chemoinformatics, Structural Informatics, and Molecular Modeling-Based Approaches / Li Xie, Sarah L Kinnings, Lei Xie, Philip E Bourne.
Systematic Phenotypic Screening for Novel Synergistic Combinations: A New Paradigm for Repositioning Existing Drugs / Margaret S Lee.
Phenotypic Screening to Identify New, Unpredicted Indications for Existing Drugs and Drug Candidates / Michael S Saporito, Christopher A Lipinski, Andrew G Reaume.
Old Drugs Yield New Discoveries: Examples from the Prodrug, Chiral Switch, and Site-Selective Deuteration Strategies / Adam J Morgan, Bhaumik A Pandya, Craig E Masse, Scott L Harbeson.
Academic and Nonprofit Initiatives and the Role of Alliances in the Drug Repositioning Industry. Repurposing Drugs for Tropical Diseases: Case Studies and Open-Source Screening Initiatives / Curtis R Chong.
Drug Repositioning Efforts by Nonprofit Foundations / Donald E Frail, Louis Degennaro, Aaron Schimmer, James Kasper, Richard Winneker, Todd B Sherer, Alison Urkowitz, Kuldip D Dave, Jill Panetta, John McCall.
Business Development Strategies in the Repositioning Industry / Aris Persidis, Elizabeth T Stark.
A Case Study in Drug Repositioning: Sosei / Akinori Mochizuki, Makiko Aoyama.
Appendix: Additional Drug Repositioning Resources and Links.
Index.
Developed for manufacturers, contract laboratories, and distributors, this reference contains the DSHEA standards and information needed to develop, manufacture, and test quality dietary supplement products.
Barratt, Michael J;Frail, Donald
- John Wiley & Sons
2011
9781118274408
9780470878279
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