Table of Contents

Chemical introduction : sources, classification, and chemical properties of drugs.
Drug administration and distribution.
Drug elimination.
Elementary pharmacokinetics.
More complex and model independent pharmacokinetic models.
Kinetics of metabolism and excretion.
Further consideration of clearance, and physiological modelling.
Drug formulation : bioavailability, bioequivalence and controlled-release preparations.
Factors affecting plasma concentrations.
Pharmacogenetics and pharmacogenomics.
Developmental pharmacology and age-related phenomena.
Effects of disease on drug disposition.
Quantitative pharmacological relationships.
Simultaneous measurement of concentrations and effect, and pharmacokinetic/pharmacodynamic (PK/PD) modelling.
Drug monitoring in therapeutics.
Drug interactions.
Drug metabolism and pharmacokinetics in toxicology.