Table of Contents

Molecular informatics : sharpening drug design's cutting edge.
High-throughput X-ray crystallography for drug discovery.
Trawling the genome for G protein-coupled receptors : the importance of integrating bioinformatic approaches.
Virtual screening of virtual libraries : an efficient startegy for lead generation.
Virtual techniques for lead optimisation.
The impact of physical organic chemistry on the control of drug-like properties.
Mutagenesis and modelling highlight the critical nature of the TM2-loop-TM3 region of biogenic amine GPCRs.
Computational vaccine design. Pharmaceutical research draws on increasingly complex techniques to solve the challenges of drug design. Bringing together a number of the latest informatics techniques, this book looks at modelling and bioinformatic strategies; structural genomics and X-ray crystallography; virtual screening; lead optimisation; ADME profiling and vaccine design. A number of relevant case studies, focussing on techniques that have demonstrated their use, will concentrate on G-protein coupled receptors as potential disease targets. Providing details of state-of-the-art research, Drug Design: Cutting Edge Approaches will be invaluable to all drug discovery scientists, including medicinal and combinatorial chemists, molecular modellers, bio- and chemoinformaticians, and pharmacologists, amongst others.