Table of Contents

Introduction to diagnostic and prognostic biomarkers and therapeutic targets in melanoma.
Diagnostic and prognostic biomarkers in melanoma: current state of play.
Molecular pathogenesis of melanoma: established andnovel pathways.
Staging of melanoma.
Clinical and histopathologocial paramenters in melanoma.
Genetic/epigentic biomarkers: distinction of melanoma from other melanocytic neoplasms.
mRNA biomarkers in melanoma.
Epigenetic biomarkers in melanoma.
MicroRNA biomarkers in melanoma.
MciroRNAs as biomarkers and therapeutic targets in melanoma.
Mitochondrial DNA biomarkers in melanoma.
Tissue-based protein biomarkers in melanoma: immunohistochemistry: (A) diagnosis.
Tissue-based protein biomarkers in melanoma: immunohistochemistry: (B) prognostication.
Tissue-based protein biomarkers in melanoma: mass spectrometry-based strategies.
Serological biomarkers in melanoma.
Molecular markers of lymph node disease in melanoma.
Melanoma cell propagation: cancer stem cell, clonal evolution and interconversion models of tumorigenicity.
Surgical management of melanoma: concept of field cancerization and molecular evaluation of tissue margins.
Chemotherapy for melanoma.
Molecular-targeted therapy for melanoma.
Anti-angiogenesis therapy for melanoma.
Immunological biomarkers and immunotherapy for melanoma.
Diagnostic and prognostic biomarkers and therapeutic targets in melanoma: an overview.