Terkko Navigator / Clinical Epigenetics

Air pollution-induced placental alterations: an interplay of oxidative stress, epigenetics, and the aging phenotype?

“Too much guts and not enough brains”: (epi)genetic mechanisms and future therapies of Hirschsprung disease — a review

Longitudinal variation in human immunodeficiency virus long terminal repeat methylation in individuals on suppressive antiretroviral therapy

Impact of a diet and activity health promotion intervention on regional patterns of DNA methylation

Deciphering DNA methylation signatures of pancreatic cancer and pancreatitis

Air pollution and DNA methylation: effects of exposure in humans

Peripheral blood DNA methylation differences in twin pairs discordant for Alzheimer’s disease

Particulate matter exposure shapes DNA methylation through the lifespan

Duration of breastfeeding is associated with leptin (LEP) DNA methylation profiles and BMI in 10-year-old children

High-resolution analysis of germ cells from men with sex chromosomal aneuploidies reveals normal transcriptome but impaired imprinting

Childhood traumatization is associated with differences in TRPA1 promoter methylation in female patients with multisomatoform disorder with pain as the leading bodily symptom

Systematic evaluation and validation of reference and library selection methods for deconvolution of cord blood DNA methylation data

Statistical predictions with glmnet

Replicated methylation changes associated with eczema herpeticum and allergic response

Deficiency and haploinsufficiency of histone macroH2A1.1 in mice recapitulate hematopoietic defects of human myelodysplastic syndrome

Promoter methylation of SEPT9 as a potential biomarker for early detection of cervical cancer and its overexpression predicts radioresistance

Novel age-associated DNA methylation changes and epigenetic age acceleration in middle-aged African Americans and whites

DNA methyltransferase isoforms expression in the temporal lobe of epilepsy patients with a history of febrile seizures

DNA methylation signature is prognostic of choroid plexus tumor aggressiveness

Aberrantly hypermethylated tumor suppressor genes were identified in oral squamous cell carcinoma (OSCC)

Urinary DNA methylation biomarkers for prediction of prostate cancer upgrading and upstaging

Characterisation of DNA methylation changes in EBF3 and TBC1D16 associated with tumour progression and metastasis in multiple cancer types

Placenta-specific epimutation at H19-DMR among common pregnancy complications: its frequency and effect on the expression patterns of H19 and IGF2

Histone methyltransferase SMYD2: ubiquitous regulator of disease

Novel prodrugs of decitabine with greater metabolic stability and less toxicity

Rheumatoid arthritis-relevant DNA methylation changes identified in ACPA-positive asymptomatic individuals using methylome capture sequencing

A prognostic CpG score derived from epigenome-wide profiling of tumor tissue was independently associated with colorectal cancer survival

Whole-genome DNA hyper-methylation in iPSC-derived dopaminergic neurons from Parkinson’s disease patients

Suv39h1 promotes facet joint chondrocyte proliferation by targeting miR-15a/Bcl2 in idiopathic scoliosis patients

Genomic and epigenomic predictors of response to guadecitabine in relapsed/refractory acute myelogenous leukemia

A combined epigenome- and transcriptome-wide association study of the oral masticatory mucosa assigns CYP1B1 a central role for epithelial health in smokers

Metabolic control of gene transcription in non-alcoholic fatty liver disease: the role of the epigenome

Functional DNA methylation signatures for autism spectrum disorder genomic risk loci: 16p11.2 deletions and CHD8 variants

Apabetalone (RVX-208) reduces vascular inflammation in vitro and in CVD patients by a BET-dependent epigenetic mechanism

Peptides as epigenetic modulators: therapeutic implications

Clustered protocadherins methylation alterations in cancer

SLCO4C1 promoter methylation is a potential biomarker for prognosis associated with biochemical recurrence-free survival after radical prostatectomy

The E3 ubiquitin ligase RNF40 suppresses apoptosis in colorectal cancer cells

DNA methylation links prenatal smoking exposure to later life health outcomes in offspring

Early-life determinants of hypoxia-inducible factor 3A gene (HIF3A) methylation: a birth cohort study

Comparative DNA methylomic analyses reveal potential origins of novel epigenetic biomarkers of insulin resistance in monocytes from virally suppressed HIV-infected adults

Parent-of-origin-specific allelic expression in the human placenta is limited to established imprinted loci and it is stably maintained across pregnancy

Comprehensive DNA methylation analysis of tissue of origin of plasma cell-free DNA by methylated CpG tandem amplification and sequencing (MCTA-Seq)

ARID1A facilitates KRAS signaling-regulated enhancer activity in an AP1-dependent manner in colorectal cancer cells

DNA methylation signature of human hippocampus in Alzheimer’s disease is linked to neurogenesis

DNA methylation changes that precede onset of dysplasia in advanced sessile serrated adenomas

DNA methylation profiling allows for characterization of atrial and ventricular cardiac tissues and hiPSC-CMs

Early-life exposure to severe famine is associated with higher methylation level in the IGF2 gene and higher total cholesterol in late adulthood: the Genomic Research of the Chinese Famine (GRECF) study

Smoking-associated AHRR demethylation in cord blood DNA: impact of CD235a+ nucleated red blood cells

Detection of HPV RNA molecules in stratified mucin-producing intraepithelial lesion (SMILE) with concurrent cervical intraepithelial lesion: a case report