Table of Contents

The organ.
Cells in the liver: functions in health and disease.
Liver physiology.
Assessment of liver function in clinical practice.
Physiology of the splanchnic and hepatic circulations.
Fibrosis as a major mechanism of chronic liver disease.
Stem cells and chronic liver failure: potential new therapeutics.
The role of inflammatory mediators in liver failure.
Genomics of the liver in health and disease.
Effects of liver failure on organ systems.
Hepatic encephalopathy and alterations of cerebral function.
Bacterial translocation and alterations of the digestive system.
SIRS, bacterial infections, and alterations of the immune system.
Regulation of the extracellular fluid volume and renal function.
The heart in chronic liver failure.
Haemostasis abnormalities in chronic liver failure.
The systemic and splanchnic circulations.
Hepatic microcirculation.
Angiogenesis and vascular growth in liver diseases.
Pulmonary alterations in chronic liver failure.
Adrenal function in chronic liver failure.
Management of chronic liver failure.
Antibiotic prophylaxis and management of bacterial infections.
Management of ascites and hyponatremia.
Management of renal failure.
Correction of abnormalities of haemostasis in chronic liver disease.
The treatment and prevention of variceal bleeding.
Extracorporeal artificial liver support systems.
Issues in transplantation of patients with chronic liver failure.
Chronic liver disease in the intensive care.