Table of Contents

Introduction / Richard B Weiskopf.
Oxygen: Chemistry, Biochemistry, Physiology and Toxicity. Hemoglobin Reactivity and Regulation / Stefano Bettati, Andrea Mozzarelli.
The Major Physiological Control Mechanisms of Blood Flow and Oxygen Delivery / Raymond C Koehler.
The Main Players: Hemoglobin and Myoglobin; Nitric Oxide and Oxygen / Tim J McMahon, Joseph Bonaventura.
The Role of Reactive Oxygen and Nitrogen Species in Ischemia/Reperfusion Injury / Ester Spagnolli, Warren M Zapol.
Medical Needs for Oxygen Supply. Acute Traumatic Hemorrhage and Anemia / Lena M Napolitano.
Diagnosis and Treatment of Haemorrhages in ₁Nonsurgical₂ Patients / Umberto Rossi, Rosa Chianese.
Management of Perioperative Bleeding / Sibylle A Kozek-Langenecker.
Oxygenation in the Preterm Neonate / Vidheya Venkatesh, Priya Muthukumar, Anna Curley, Simon Stanworth.
Ischemia / Hooman Mirzakhani, Ala Nozari.
Normobaric and Hyperbaric Oxygen Therapy for Ischemic Stroke and Other Neurological Conditions / Ari Moskowitz, Yu-Feng Yvonne Chan, Aneesh B Singhal.
Transfusion Therapy in Thalassemia and Sickle Cell Disease / Carlo Brugnara, Lucia De Franceschi.
₃Old₄ and New Strategies for Oxygen Supply. Transfusion: Political, Administrative and Logistic Issues / John R Hess, Giuliano Grazzini.
Conscientious Objection in Patient Blood Management / Kenneth E Nollet, Hitoshi Ohto.
Red-Cell Transfusion in Clinical Practice / Harvey G Klein.
Causes and Consequences of Red Cell Incompatibility / Chisa Yamada, Robertson Davenport.
Biochemistry of Storage of Red Blood Cells / Ryan Stapley, Dario A Vitturi, Rakesh P Patel.
Proteomic Investigations of Stored Red Blood Cells / Lello Zolla, Angelo D'Alessandro.
Red Blood Cells from Stem Cells / Anna Rita Migliaccio, Carolyn Whitsett, Giovanni Migliaccio.
The Universal Red Blood Cell / Luca Ronda, Serena Faggiano.
Allosteric Effectors of Hemoglobin: Past, Present and Future / Martin K Safo, Stefano Bruno.
Hemoglobin-Based Oxygen Carriers: History, Limits, Brief Summary of the State of the Art, Including Clinical Trials / Jonathan S Jahr, Arezou Sadighi, Linzy Doherty, Alvin Li, Hae Won Kim.
Oxygen Delivery by Natural and Artificial Oxygen Carriers / Enrico Bucci.
Crosslinked and Polymerized Hemoglobins as Potential Blood Substitutes / Kenneth W Olsen, Eugene Tarasov.
Engineering the Molecular Shape of PEG-Hemoglobin Adducts for Supraperfusion / Seetharama A Acharya, Marcos Intaglietta, Amy G Tsai, Kulal Ananda, Fantao Meng.
Hb Octamers by Introduction of Surface Cysteines / V̌ronique Baudin-Creuza, Chien Ho, Michael C Marden.
Hemoglobin Vesicles as a Cellular-Type Hemoglobin-Based Oxygen Carrier / Hiromi Sakai, Hirohisa Horinouchi, Eishun Tsuchida, Koichi Kobayashi.
Animal Models and Oxidative Biomarkers to Evaluate Preclinical Safety of Extracellular Hemoglobins / Paul W Buehler, Felice D'Agnillo.
Academia-Industry Collaboration in Blood Substitute Development: Issues, Case Histories and a Proposal / Hae Won Kim, Andrea Mozzarelli, Hiromi Sakai, Jonathan S Jahr. Scientists are developing oxygen therapeutics, or "blood substitutes," with the same oxygen-carrying capability as blood, that can be used as replacements for blood transfusion or to treat diseases where oxygen transport is impaired. This book links the underlying biochemical principles of the field with chemical and biotechnological innovations and pre-clinical development, starting with the observation that an oxygen therapeutic agent can be developed only upon a deep understanding of oxygen and nitric oxide, homeostasis and regulation, and the well-documented correlations between adverse effects of a specific product and its biochemical-physiological properties.