Terkko Navigator / Cellular immunology

The CBM complex: A growing multiplicity of cellular functions, regulatory mechanisms and connections to human disease.

Bcl10 is associated with actin dynamics at the T cell immune synapse.

CARD19, the protein formerly known as BinCARD, is a mitochondrial protein that does not regulate Bcl10-dependent NF-κB activation after TCR engagement.

Regulation of an adaptor protein STING by Hsp90β to enhance innate immune responses against microbial infections.

New disease old vaccine: Is recombinant BCG vaccine an answer for COVID-19?

Deltex-1 is indispensible for the IL-6 and TGF-β treatment-triggered differentiation of Th17 cells.

Critical protein-protein interactions within the CARMA1-BCL10-MALT1 complex: Take-home points for the cell biologist.

Tolerogenic vaccines: Targeting the antigenic and cytokine niches of FOXP3+ regulatory T cells.

Regulatory T cells: Master thieves of the immune system.

Transdermal entry of yeast components elicits transient B cell-associated responses in skin-draining lymph nodes.

The role of miRNA-155 in the immunopathogenesis of obliterative airway disease in mice induced by circulating exosomes from human lung transplant recipients with chronic lung allograft dysfunction.

Application of directed evolution and back-to-consensus algorithms to human alpha1-antitrypsin leads to diminished anti-protease activity and augmented anti-inflammatory activities.

THP-1 cells increase TNF-α production upon LPS + soluble human IgG co-stimulation supporting evidence for TLR4 and Fcγ receptors crosstalk.

The assembly of glycosphingolipid determines their immunomodulatory effect: A novel method for structure-based design of immunotherapy.

Dietary oligosaccharides attenuate DSS-induced colitis in mice, induce PGlyRP3 expression, and inhibit NF-κB and MEK/ERK signaling.

IL-7 receptor alpha defines heterogeneity and signature of human effector memory CD8+ T cells in high dimensional analysis.

Introduction to this Cellular Immunology issue on new advances in solid organ transplantation immunology.

Combined TLR4 and TLR9 agonists induce distinct phenotypic changes in innate immunity in vitro and in vivo.

Stimulation with FITC-labeled antigens confers B cells with regulatory properties.

Regulation and dysregulation of CARD14 signalling and its physiological consequences in inflammatory skin disease.

Promoter anchored interaction landscape of THP-1 macrophages captures early immune response processes.

Infectious tolerance. What are we missing?

Recombinant Rv3261 protein of Mycobacterium tuberculosis induces apoptosis through a mitochondrion-dependent pathway in macrophages and inhibits intracellular bacterial growth.

Intranasal delivery of cationic liposome-protamine complex mRNA vaccine elicits effective anti-tumor immunity.

Surviving the storm: Dealing with COVID-19.

Humoral autoimmunity after solid organ transplantation: Germinal ideas may not be natural.

Viral and tumor antigen-specific CD8 T-cell responses in Merkel cell carcinoma.

Regulation of aquaporin 4 expression by lipoxin A4 in astrocytes stimulated by lipopolysaccharide.

TIGIT expression is upregulated in T cells and causes T cell dysfunction independent of PD-1 and Tim-3 in adult B lineage acute lymphoblastic leukemia.

Protease-activated receptor 4 protects mice from Coxsackievirus B3 and H1N1 influenza A virus infection.

DosR antigen Rv1737c induces activation of macrophages dependent on the TLR2 pathway.

High iodine induces DNA damage in autoimmune thyroiditis partially by inhibiting the DNA repair protein MTH1.

Multi-modal image cytometry approach - From dynamic to whole organ imaging.

Dampening of mast cell secondary responses to allergen involves specific signalling and epigenetic changes.

Mal-deficiency impairs the tolerogenicity of dendritic cell of patients with allergic rhinitis.

Matters of life and death: How estrogen and estrogen receptor binding to the immunoglobulin heavy chain locus may influence outcomes of infection, allergy, and autoimmune disease.

TLR9 signaling mediates adaptive immunity following systemic AAV gene therapy.

MDSCs in pregnancy: Critical players for a balanced immune system at the feto-maternal interface.

Impairment of PD-L2 positive B1a cells enhances susceptibility to sepsis in RasGRP1-deficient mice.

Regulatory T cells in allogeneic hematopoietic stem cell transplantation: From the lab to the clinic.

The AIRE Ser196Ser synonymous variant is a risk factor for systemic lupus erythematosus.

Analysis of macrophages and neutrophils infiltrating murine mammary carcinoma sites within hours of tumor delivery.

Diminished immune responses with aging predispose older adults to common and uncommon influenza complications.

Fcγ receptors and toll-like receptor 9 synergize to drive immune complex-induced dendritic cell maturation.

Expression and regulation of telomerase in human T cell differentiation, activation, aging and diseases.

Testosterone treatment of aged male mice improves some but not all aspects of age-associated increases in influenza severity.

The impact of sex and age on T cell immunity and ischemic stroke outcomes.

The promise of chimeric antigen receptor (CAR) T cell therapy in multiple myeloma.

B cells from young and old mice switch isotypes with equal frequencies after ex vivo stimulation.

Conjugated CAR T cell one step beyond conventional CAR T cell for a promising cancer immunotherapy.