Table of Contents

Basic science, section I: sub-cellular mechanisms of cardiac mechano-electric coupling.
Evolutionary origins of stretch-activated ion channels.
Stretch-activated channels in the heart.
The mechano-gated K2P channel TREK-1 in the cardiovascular system.
Cell volume-sensitive ion channels and transporters in cardiac myocytes.
The response of cardiac muscle to stretch: calcium and force.
Stretch effects on second messengers.
Functional implications of myocyte architecture.
Mechanical modulation of pacemaker electrophysiology.
Mechano-electric coupling in working cardiomyocytes: diastolic and systolic effects.
Mechano-sensitivity of pulmonary vein cells: implications for atrial arrhythmogenesis.
Heterogeneity of sarcomere length and function as a cause of arrhythmogenic calcium waves.
Cellular mechanisms of arrhythmogenic cardiac alternans.
Remodeling of gap junctions in ventricular myocardium: effects of cell-to-cell adhesion, mediators of hypertrophy and mechanical forces.
The origin of fibroblasts, ECM and potential contributions to cardiac mechano-electric coupling.
Advantages and pitfalls of cell cultures as model systems to study cardiac mechanoelectric coupling.
Activation sequence of cardiac muscle in simplified experimental models: relevance for cardiac mechano electric coupling.
Acute stretch effects on atrial electro-physiology.
Stretch effects on potassium accumulation and alternans in pathological myocardium.
The effects of wall stretch on ventricular conduction and refractoriness in the whole heart.
Mechanical triggers of long-term ventricular electrical remodeling.
Mechanisms of mechanical pre- and postconditioning.
Mechano-electric coupling in chronic atrial fibrillation.
Mechanically induced pulmonary vein ectopy.
insight from animal models.
Regional variation in mechano-electric coupling: the right ventricle.
Mechanical induction of arrhythmia in the ex-situ heart: insight into commotio cordis.
Arrhythmias in murine models of the mechanically impaired heart.
Studying cardiac mechano-sensitivity in man.
Mathematical models of cardiac structure and function: mechanistic insights from models of heart failure.
Mathematical models of human atrial mechano-electrical coupling and arrhythmias.
Mathematical models of ventricular mechano-electric coupling and arrhythmia.
Load dependence of ventricular repolarisation.
Is the U wave in the electrocardiogram a mechanoelectrical phenomenon?.
Mechanical modulation of cardiac function: role of the pericardium.
Mechanically-induced electrical remodelling in human atrium.
Drug effects and atrial fibrillation: potential and limitations.
Stretch as a mechanism linking short- and long-term electrical remodeling in the ventricles. Volume and pressure overload and ventricular arrhythmogenesis.
Stretch effects on fibrillation dynamics.
Commotio cordis: sudden death from blows to the chest wall.
Repolarization changes in the synchronously and dys-synchronously contracting failing heart.
Ventricular arrhythmias in heart failure: link to hemodynamic load.
Mechanical heterogeneity and aftercontractions as trigger of torsades des pointes.
Stretch-induced arrhythmias in ischaemia.
Antiarrhythmic effects of acute mechanical stimulation.
Termination of arrhythmias by haemodynamic unloading.
Mechanical modulation of defibrillation and resuscitation efficacy.
Anti- and pro-arrhythmic effects of cardiac assist device implantation.
Anti- and pro-arrhythmic effects of cardiac resynchronization therapy.
Evidence for mechano-electric coupling from clinical trials on AF.
Evidence for mechano-electric coupling from clinical trials in heart failure.
Mechano-electrical coupling and the pathogenesis of arrhythmogenic right ventricular cardiomyopathy.
Evidence for mechano-electric coupling from clinical trials on cardiac resynchronization therapy.
Mechano-electric coupling in patients treated with ventricular assist devices: insights from individual cases and clinical trials.
Measuring strain of structural proteins in vivo in real time.
Roles of SAC beyond M-E transaction.
Distributions of myocyte stress, strain and work in normal and infarcted ventricles.
Evolving concepts in measuring ventricular strain in the canine and human hearts: non-invasive imaging.
Evolving concepts in measuring ventricular strain in the human heart: impedance measurements.
Mechanosensitive channel blockers: a new class of antiarrhythmic drugs?