Terkko Navigator / Cancer Discovery

In This Issue [In This Issue]

Bispecific Antibody Takes Down FL [News in Brief]

"Very Compelling" Results for ADC in TNBC Trial [News in Brief]

Novel SERD Has PFS Edge against Breast Cancer [News in Brief]

Tumor Profiling Improves Breast Cancer PFS [News in Brief]

Noted [News in Brief]

Navigating Cancer Care in the COVID-19 Era [News in Depth]

Pandemic Puts Telehealth to the Test [News in Depth]

Transition to NK-Like T Cells Is a Mechanism Behind CAR T-cell Exhaustion [Immunotherapy]

Colonic Microbiota Promote Antitumor Immunity in Colorectal Cancer [Microbiome]

The CLIP1-LTK Fusion Is an Oncogenic Driver of NSCLC [Lung Cancer]

High Expression of Histamine Receptor, HRH1, Reduces Immunotherapy Response [Immunotherapy]

Tumor Microenvironment Influences Cancer Cell Transcriptional State [Tumor Microenvironment]

Surface Expression of NRP1 on Tregs Affects Outcome in Patients with Cancer [Immunology]

Nongenetic Cell-Intrinsic Properties Govern Malignant Clonal Fitness [Tumor Heterogeneity]

T Cells Targeting TdT Selectively Kill Leukemic Lymphoblasts [Immunotherapy]

Premalignant Colorectal Polyps Can Map Divergent Tumor Landscapes [Colorectal Cancer]

Pembrolizumab Addition Improves Clinical Response in HER2+ Gastric Cancer [Clinical Trial]

Functional Precision Medicine: Putting Drugs on Patient Cancer Cells and Seeing What Happens [In the Spotlight]

Shedding Light on ecDNA Behavior Using CRISPR-Based Live-Cell Imaging [In the Spotlight]

The Few yet Fabp4ulous Pancreatic Stellate Cells Give Rise to Protumoral CAFs [In the Spotlight]

Improving the Affordability of Anticancer Medicines Demands Evidence-Based Policy Solutions [Science in Society]

Learning through a Pandemic: The Current State of Knowledge on COVID-19 and Cancer [Reviews]

A Summary of the Inaugural WHO Classification of Pediatric Tumors: Transitioning from the Optical into the Molecular Era [Reviews]

INK4 Tumor Suppressor Proteins Mediate Resistance to CDK4/6 Kinase Inhibitors [Research Brief]

Functional Precision Medicine Provides Clinical Benefit in Advanced Aggressive Hematologic Cancers and Identifies Exceptional Responders [Research Articles]

Implementing a Functional Precision Medicine Tumor Board for Acute Myeloid Leukemia [Research Articles]

Futibatinib, an Irreversible FGFR1-4 Inhibitor, in Patients with Advanced Solid Tumors Harboring FGF/FGFR Aberrations: A Phase I Dose-Expansion Study [Research Articles]

Repurposing Vandetanib plus Everolimus for the Treatment of ACVR1-Mutant Diffuse Intrinsic Pontine Glioma [Research Articles]

An In Vivo CRISPR Screening Platform for Prioritizing Therapeutic Targets in AML [Research Articles]

SLC5A3-Dependent Myo-inositol Auxotrophy in Acute Myeloid Leukemia [Research Articles]

Live-Cell Imaging Shows Uneven Segregation of Extrachromosomal DNA Elements and Transcriptionally Active Extrachromosomal DNA Hubs in Cancer [Research Articles]

Mesenchymal Lineage Heterogeneity Underlies Nonredundant Functions of Pancreatic Cancer-Associated Fibroblasts [Research Articles]

Transcription Elongation Machinery Is a Druggable Dependency and Potentiates Immunotherapy in Glioblastoma Stem Cells [Research Articles]

Sex-Biased ZRSR2 Mutations in Myeloid Malignancies Impair Plasmacytoid Dendritic Cell Activation and Apoptosis [Research Articles]

MYC Levels Regulate Metastatic Heterogeneity in Pancreatic Adenocarcinoma [Research Articles]

Smarca4 Inactivation Promotes Lineage-Specific Transformation and Early Metastatic Features in the Lung [Research Articles]

In This Issue [In This Issue]

Exome Sequencing IDs Hidden Disease Variants [News in Brief]

CSF2-STAT5 Signaling in TAMs Contributes to CSF1R Inhibition Resistance [Metastasis]

Low-Glycemic Diets Restrict Tumor Growth through Altered Lipid Metabolism [Metabolism]

Telomeric Parameters Improve Glioma Diagnosis and Liquid Biopsy Approaches [Glioma]

Tumor-Secreted Lipids Induce ER Stress Response to Polarize Macrophages [Immunology]

Collagen Receptor Implicated in Immune Exclusion [News in Brief]

As Maintenance Therapy, Olaparib's Benefits Continue [News in Brief]

TFOs Directly Targeting Amplified Oncogenic Drivers Promote Apoptosis [Targeted Therapy]

Case Builds for Booster Shots for People with Cancer [News in Brief]

Personalized DNA Vaccine Tamps Down HCC [News in Brief]

Ibrutinib with R-CHOP Differentially Affects Genetic Subtypes of DLBCL [Lymphoma]

Highly Focused Radiation May Curb Oligoprogression [News in Brief]