Table of Contents

FOREWORD ; PREFACE ; List of Contributors ; Epidemiology and Social Costs ; INTRODUCTION; DEFINITION; EPIDEMIOLOGY; Risk Factors; Unmodifiable Risk Factors: ; Modifiable Risk Factors:; PREVENTION; INCIDENCE, PREVALENCE AND MORTALITY; SOCIETAL COSTS; ENDOVASCULAR TREATMENT AND VENOUS FIBRINOLYSIS: SOCIO-ECONOMIC COMPARISON; WHICH ENDOVASCULAR TREATMENT TO USE?; CONCLUSION; CONFLICT OF INTEREST ; ACKNOWLEDGEMENTS; REFERENCES; Brain Ischemia and Stroke: Mechanisms and Opportunities ; ABSOLUTE DEPENDENCE ON BLOOD FLOW; HETEROGENEOUS ORGAN; ISCHEMIC CORE; CYTOTOXIC AND VASOGENIC EDEMA. INTRAVENOUS THROMBOLYSIS IN THE REAL WORLD: BEYOND CONTRAINDICATIONS?NEW THROMBOLYTIC AGENTS AND NEW MEDICAL REPERFUSION STRATEGIES; CONCLUSION; CONFLICT OF INTEREST; ACKNOWLEDGEMENTS; REFERENCES; Endovascular Stroke Therapy: Devices and Different Approaches ; INTRODUCTION; SELECTION PATIENTS FOR ENDOVASCULAR TREATMENT; Recent Trials; ENDOVASCULAR RECANALIZATION STRATEGIES; Mechanical Thrombectomy Devices; MERCI; STENT-TRIEVERS; Solitaire FR; TREVO; REVIVE; Tromboaspirating Devices; PENUMBRA SYSTEM; COMBINED SUCTION EMBOLECTOMY AND MECHANICAL RETRIEVAL; CONFLICT OF INTEREST; ACKNOWLEDGEMENTS. NECROSIS AND PROGRAMMED CELL DEATHSMATURATION PHENOMENON; PERINECROSIS AREAS; MECHANISMS ASSOCIATED WITH ISCHEMIC DAMAGE; DOUBLE SWORD PROCESS; EVIDENCE LINKING STROKE AND INFLAMMATION; NOT JUST A LOCAL EVENT; DIFFERENTIATING PRO-LIFE AND PRO-DEATH MECHANISMS; OPPORTUNITIES; BOXES; Box 1 Theoretical Models for Measuring Cerebral Blood Flow and Metabolism; Box 2 NMDA Receptors; Box 3 Programmed Cell Deaths; Box 4 Oxidative Stress; Box 5 Complement, Ficolins and MBL; Box 6 Adhesion Molecules; Box 7 Lymphocytes and Stroke; CONFLICT OF INTEREST ; ACKNOWLEDGEMENTS; REFERENCES. New Imaging Techniques INTRODUCTION; PATHOPHYSIOLOGY; CEREBRAL VASCULAR TERRITORIES AND CLINICAL PRESENTATION; IMAGING ; Acute Phase ; Computed Tomography (CT); Magnetic Resonance Imaging (MRI); Subacute Phase; Computed Tomography (CT); Magnetic Resonance Imaging (MRI); Chronic Phase ; Computed Tomography (CT); Magnetic Resonance Imaging (MRI) ; VENOUS INFARCT; THERAPY: THE ROLE OF IMAGING; CONFLICT OF INTEREST; ACKNOWLEDGEMENTS; REFERENCES; Medical Acute Stroke Treatment ; INTRODUCTION; GENERAL SUPPORTIVE CARE; STROKE UNIT; INTRAVENOUS THROMBOLYSIS; SYMPTOMATIC HEMORRHAGIC TRANSFORMATION.