Foundations of regenerative biology and medicine
Regenerative medicine Tissue engineering
IOP Publishing
2018
EISBN 9780750316262
part I. Regenerative biology. 1. Regeneration.
1.1. Introduction.
1.2. Who and what regenerates?.
1.3. A brief history of regenerative biology.
1.4. The regenerative niche.
1.5. Approaches to the study of regeneration.
1.6. Mechanisms of regeneration.
1.7. Transdifferentiation.
1.8. Regeneration by adult stem cells.
1.9. Some tissues use multiple mechanisms of regeneration
2. Wound repair by fibrosis.
2.1. Fibrosis is studied primarily in skin.
2.2. Structure and function of skin.
2.3. Types of wounds.
2.4. Stages of repair in acute wounds.
2.5. Aging reduces the repair capacity of acute skin wounds.
2.6. Chronic wounds fail to heal.
2.7. Non-scarring skin repair models.
2.8. Comparative molecular analysis of wound repair and regeneration
3. Regeneration by adult stem cells.
3.1. Epithelial stem cells.
3.2. Mesenchymal stem cells.
3.3. Stem cells in non-regenerating organs
4. Non-stem cell regenerative mechanisms.
4.1. Cellular re-growth: axon regeneration.
4.2. Regeneration from pre-existing differentiated cells.
4.3. Transdifferentiation: newt lens and retina
5. Appendage regeneration.
5.1. Limb regeneration in urodele amphibians.
5.2. Appendage regeneration in Xenopus.
5.3. Mouse digit tip regeneration.
5.4. Regeneration of mouse ear tissue.
5.5. Regeneration of deer antlers.
5.6. Enhancement of appendage regeneration
part II. Regenerative medicine. 6. Strategies of regenerative medicine.
6.1. Historical notes.
6.2. Biomimetic devices and organ transplants.
6.3. Pharmaceutical induction of regeneration in situ.
6.4. Cell transplants.
6.5. Biomimetic tissues
7. Pharmaceutical therapies for wound repair and regeneration.
7.1. Skin.
7.2. Neural tissues.
7.3. Musculoskeletal tissues.
7.4. Cardiac muscle
8. Cell transplants as regenerative therapy.
8.1. Skin.
8.2. Neural tissues.
8.3. Liver and pancreas.
8.4. Musculoskeletal tissues.
8.5. Cardiac tissues.
8.6. Hematopoietic deficiency disorders
9. Biomimetic tissues and organs.
9.1. Skin.
9.2. Muscle.
9.3. Bone.
9.4. Articular cartilage.
9.5. Cardiovascular tissue.
9.6. Liver and pancreas.
9.7. Airways.
9.8. Kidney and bladder
10. Into the adjacent possible.
10.1. Technical innovations.
10.2. Applications of edge technologies.
10.3. Bioethics in regenerative medicine.
10.4. Concluding statement.
Regenerative biology and medicine is a rapidly developing field that can revolutionize medicine. It is a nexus of convergent science, drawing from chemistry, physics, mathematics and bioengineering. Foundations of Regenerative Biology and Medicine introduces the essentials of regenerative biology and medicine to advanced undergraduates and beginning graduate students, as well as students and professionals outside the field who need (and want) an introduction to the subject. This relatively short ten chapter book can be read in one semester and delivers the essential framework to understand the biological aspects of different mechanisms of regeneration and the therapeutic strategies that have emerged from this biology.
1.1. Introduction.
1.2. Who and what regenerates?.
1.3. A brief history of regenerative biology.
1.4. The regenerative niche.
1.5. Approaches to the study of regeneration.
1.6. Mechanisms of regeneration.
1.7. Transdifferentiation.
1.8. Regeneration by adult stem cells.
1.9. Some tissues use multiple mechanisms of regeneration
2. Wound repair by fibrosis.
2.1. Fibrosis is studied primarily in skin.
2.2. Structure and function of skin.
2.3. Types of wounds.
2.4. Stages of repair in acute wounds.
2.5. Aging reduces the repair capacity of acute skin wounds.
2.6. Chronic wounds fail to heal.
2.7. Non-scarring skin repair models.
2.8. Comparative molecular analysis of wound repair and regeneration
3. Regeneration by adult stem cells.
3.1. Epithelial stem cells.
3.2. Mesenchymal stem cells.
3.3. Stem cells in non-regenerating organs
4. Non-stem cell regenerative mechanisms.
4.1. Cellular re-growth: axon regeneration.
4.2. Regeneration from pre-existing differentiated cells.
4.3. Transdifferentiation: newt lens and retina
5. Appendage regeneration.
5.1. Limb regeneration in urodele amphibians.
5.2. Appendage regeneration in Xenopus.
5.3. Mouse digit tip regeneration.
5.4. Regeneration of mouse ear tissue.
5.5. Regeneration of deer antlers.
5.6. Enhancement of appendage regeneration
part II. Regenerative medicine. 6. Strategies of regenerative medicine.
6.1. Historical notes.
6.2. Biomimetic devices and organ transplants.
6.3. Pharmaceutical induction of regeneration in situ.
6.4. Cell transplants.
6.5. Biomimetic tissues
7. Pharmaceutical therapies for wound repair and regeneration.
7.1. Skin.
7.2. Neural tissues.
7.3. Musculoskeletal tissues.
7.4. Cardiac muscle
8. Cell transplants as regenerative therapy.
8.1. Skin.
8.2. Neural tissues.
8.3. Liver and pancreas.
8.4. Musculoskeletal tissues.
8.5. Cardiac tissues.
8.6. Hematopoietic deficiency disorders
9. Biomimetic tissues and organs.
9.1. Skin.
9.2. Muscle.
9.3. Bone.
9.4. Articular cartilage.
9.5. Cardiovascular tissue.
9.6. Liver and pancreas.
9.7. Airways.
9.8. Kidney and bladder
10. Into the adjacent possible.
10.1. Technical innovations.
10.2. Applications of edge technologies.
10.3. Bioethics in regenerative medicine.
10.4. Concluding statement.
Regenerative biology and medicine is a rapidly developing field that can revolutionize medicine. It is a nexus of convergent science, drawing from chemistry, physics, mathematics and bioengineering. Foundations of Regenerative Biology and Medicine introduces the essentials of regenerative biology and medicine to advanced undergraduates and beginning graduate students, as well as students and professionals outside the field who need (and want) an introduction to the subject. This relatively short ten chapter book can be read in one semester and delivers the essential framework to understand the biological aspects of different mechanisms of regeneration and the therapeutic strategies that have emerged from this biology.
