Applications of toxicogenomics in safety evaluation and risk assessment
Genetic toxicology Health risk assessment Toxicity testing Toxicogenetics Risk Assessment HEALTH & FITNESS / Diseases / Genetic MEDICAL / Genetics Electronic resource sähkökirjat
John Wiley & Sons
2011
EISBN 9781118001035
Frontmatter.
Color Plates.
Toxicology, ₃Omics₄ Technologies, and Toxicogenomics: A Primer / Darrell R Boverhof, B Bhaskar Gollapudi.
Introduction to Human Health Risk Assessment / Irene Baskerville-Abraham, Alison Willis, Bernard Gadagbui, Lynne T Haber.
Practical Considerations for the Application of Toxicogenomics to Risk Assessment: Early Experience, Current Drivers, and a Path Forward / Darrell R Boverhof, David R Geter, B Bhaskar Gollapudi, Heli Hollnagel.
Approaches and Practical Considerations for the Analysis of Toxicogenomics Data / Zhenqiang Su, Hong Fang, Weida Tong, Huixiao Hong, Roger Perkins, Lei Guo, Leming Shi.
Genomics in Identifying Mutagenic Mode of Action in Carcinogenesis / Jiri Aubrecht, Ebru Caba.
Application of Genomics for Predicting and Understanding the Mode of Action for Nongenotoxic Carcinogens / Mark R Fielden.
Genomics in Characterizing Endocrine Toxicity / Jorge M Naciff, George P Daston.
Studying Organ-Specific Toxicity Using Gene-Expression Profiling / M Ann Mongan, Hisham K Hamadeh.
Toxicogenomic Studies in Human Populations / Cliona M McHale, Luoping Zhang, Alan E Hubbard, Martyn T Smith.
Toxicogenomics Applied to Ecological Risk Assessment / Daniel L Villeneuve, Gerald T Ankley, Dalma Martinovic.
Analysis of Transcriptomic Dose₆Response Data for Toxicology and Risk Assessment / Russell S Thomas, Longlong Yang, Harvey J Clewell, Melvin E Andersen.
Toxicogenomics as a Tool for Validating Animal to Human Extrapolations in Chemical Risk Assessment: Concepts, Applications, and Challenges / Alan Dombkowski, J Craig Rowlands.
Toxicogenomics and Animal Alternatives / Anne S Kienhuis, Joost H M van Delft, Jos C S Kleinjans.
Toxicogenomics and the Regulatory Framework / Kathryn Gallagher, Federico M Goodsaid, David J Dix, Susan Y Euling, Melissa Kramer, Nancy E McCarroll, Julian R Preston, Philip G Sayre, Banalata Sen, Douglas C Wolf, William H Benson.
Standardization of Gene-Expression Information for the Safety Evaluation: Activities in Japan / Ken-Ichi Aisaki, Jun Kanno.
Applying Transcriptional Profiling in Drug Safety Evaluation / Lois D Lehman-McKeeman, William R Foster.
Reframing the Risk Assessment Paradigm: Toward a Systems Biology Approach / Sarah N Campion, Kim Boekelheide.
Index.
Toxicology, "omics" technologies, and toxicogenomics : a primer.
Introduction to human health risk assessment.
Practical considerations for the application of toxicogenomics to risk assessment--early experience, current drivers, and a path forward.
Approaches and practical considerations for the analysis of toxicogenomics data.
Genomics in identifying mutagenic mode of action in carcinogenesis.
Application of genomics for predicting and understanding the mode of action for non-genotoxic carcinogens.
Genomics in characterizing endocrine toxicity.
Studying organ specific toxicity using gene expression profiling.
Toxicogenomic studies in human populations.
Toxicogenomics applied to ecological risk assessment.
Analysis of transcriptomic dose response data for toxicology and risk assessment.
Toxicogenomics as a tool for validating animal to human extrapolations in chemical risk assessment: concepts, applications and challenges.
Toxicogenomics and animal alternatives.
Toxicogenomics and the regulatory framework.
Standardization of gene expression information for the safety evaluation--activities in Japan.
-- Applying transcriptional profiling in drug safety evaluation.
Reframing the risk assessment paradigm : towards a systems biology approach.
This book provides a timely overview of toxicogenomics, with special emphasis on the practical applications of this technology to the risk assessment process. Introductory sections are followed by a series of chapters highlighting practical and systematic applications of toxicogenomics in informing the risk assessment process - including the areas of mutagenicity, carcinogenicity, endocrine toxicity, organ-specific toxicity, population monitoring, and ecotoxicology. The book concludes with approaches for the integration of this technology in safety evaluation studies, and an outlook on how toxicogenomics and complementary technologies can reframe the current risk assessment paradigm.
Color Plates.
Toxicology, ₃Omics₄ Technologies, and Toxicogenomics: A Primer / Darrell R Boverhof, B Bhaskar Gollapudi.
Introduction to Human Health Risk Assessment / Irene Baskerville-Abraham, Alison Willis, Bernard Gadagbui, Lynne T Haber.
Practical Considerations for the Application of Toxicogenomics to Risk Assessment: Early Experience, Current Drivers, and a Path Forward / Darrell R Boverhof, David R Geter, B Bhaskar Gollapudi, Heli Hollnagel.
Approaches and Practical Considerations for the Analysis of Toxicogenomics Data / Zhenqiang Su, Hong Fang, Weida Tong, Huixiao Hong, Roger Perkins, Lei Guo, Leming Shi.
Genomics in Identifying Mutagenic Mode of Action in Carcinogenesis / Jiri Aubrecht, Ebru Caba.
Application of Genomics for Predicting and Understanding the Mode of Action for Nongenotoxic Carcinogens / Mark R Fielden.
Genomics in Characterizing Endocrine Toxicity / Jorge M Naciff, George P Daston.
Studying Organ-Specific Toxicity Using Gene-Expression Profiling / M Ann Mongan, Hisham K Hamadeh.
Toxicogenomic Studies in Human Populations / Cliona M McHale, Luoping Zhang, Alan E Hubbard, Martyn T Smith.
Toxicogenomics Applied to Ecological Risk Assessment / Daniel L Villeneuve, Gerald T Ankley, Dalma Martinovic.
Analysis of Transcriptomic Dose₆Response Data for Toxicology and Risk Assessment / Russell S Thomas, Longlong Yang, Harvey J Clewell, Melvin E Andersen.
Toxicogenomics as a Tool for Validating Animal to Human Extrapolations in Chemical Risk Assessment: Concepts, Applications, and Challenges / Alan Dombkowski, J Craig Rowlands.
Toxicogenomics and Animal Alternatives / Anne S Kienhuis, Joost H M van Delft, Jos C S Kleinjans.
Toxicogenomics and the Regulatory Framework / Kathryn Gallagher, Federico M Goodsaid, David J Dix, Susan Y Euling, Melissa Kramer, Nancy E McCarroll, Julian R Preston, Philip G Sayre, Banalata Sen, Douglas C Wolf, William H Benson.
Standardization of Gene-Expression Information for the Safety Evaluation: Activities in Japan / Ken-Ichi Aisaki, Jun Kanno.
Applying Transcriptional Profiling in Drug Safety Evaluation / Lois D Lehman-McKeeman, William R Foster.
Reframing the Risk Assessment Paradigm: Toward a Systems Biology Approach / Sarah N Campion, Kim Boekelheide.
Index.
Toxicology, "omics" technologies, and toxicogenomics : a primer.
Introduction to human health risk assessment.
Practical considerations for the application of toxicogenomics to risk assessment--early experience, current drivers, and a path forward.
Approaches and practical considerations for the analysis of toxicogenomics data.
Genomics in identifying mutagenic mode of action in carcinogenesis.
Application of genomics for predicting and understanding the mode of action for non-genotoxic carcinogens.
Genomics in characterizing endocrine toxicity.
Studying organ specific toxicity using gene expression profiling.
Toxicogenomic studies in human populations.
Toxicogenomics applied to ecological risk assessment.
Analysis of transcriptomic dose response data for toxicology and risk assessment.
Toxicogenomics as a tool for validating animal to human extrapolations in chemical risk assessment: concepts, applications and challenges.
Toxicogenomics and animal alternatives.
Toxicogenomics and the regulatory framework.
Standardization of gene expression information for the safety evaluation--activities in Japan.
-- Applying transcriptional profiling in drug safety evaluation.
Reframing the risk assessment paradigm : towards a systems biology approach.
This book provides a timely overview of toxicogenomics, with special emphasis on the practical applications of this technology to the risk assessment process. Introductory sections are followed by a series of chapters highlighting practical and systematic applications of toxicogenomics in informing the risk assessment process - including the areas of mutagenicity, carcinogenicity, endocrine toxicity, organ-specific toxicity, population monitoring, and ecotoxicology. The book concludes with approaches for the integration of this technology in safety evaluation studies, and an outlook on how toxicogenomics and complementary technologies can reframe the current risk assessment paradigm.
