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Hormone (Lipocalin-1) Found to Switch Off Hunger; Potential to Help Treat Body Weight Problems

AstraZeneca/Oxford Vaccine for COVID-19 Achieves Interim Efficacies of 90% and 62% in Trials of Two Different Dose Regimens; Up to 3 Billion Doses Planned for 2021

Tarantula Toxin Locks Voltage-Gated Sodium Channels in Nerve Cells; Cryo-EM Study of Mechanism May Offer Clues to Treating Chronic Pain

Fat-Released Exosomes May Offer Clues to COVID-19; Adipose Tissue May Be Source of Inflammatory Factors That Aggravate COVID-19; Adipose Tissue of COVID-19 Patients Develop Syndrome Similar to Cachexia, Wasting Disease Seen in Cancer, Other Diseases

Regeneron's REGEN-COV2 Antibody Cocktail for COVID-19 Receives FDA Emergency Use Authorization (EUA) for Recently Diagnosed, Mild to Moderate COVID-19 In High-Risk Patients

Home Monitoring of Glaucoma May Be Enabled by New Technology Approach (“Eyecatcher”)

Zebra Finches Can Rapidly Memorize Signature Sounds of at Least 50 Different Members of Their Flock

PROGERIA: First-Ever Treatment (Zokinvy) for Ultra-Rare, Rapid-Aging Disease Receives U.S. FDA Approval;“Monumental Event,” Foundation Leader States; Connections with Heart Disease & Aging May Result in Much Broader Insights Applicable to Million

Researchers Create First Global Map of Bee Species Diversity (20,000+); New Work May Help in the Conservation of Bees As Global Pollinators

Researchers ID Potential Cellular Target for Eliminating Bone Breakdown in Osteoporosis

Preliminary Evidence That Inhibitors of Thiol-Mediated Uptake May Block Entry of SARS-C0V-2 into Target Cells

Study Finds Evidence That Hyperbaric Oxygen Treatments Halt/Reverse Aging Process—Telomeres Lengthened and Number of Senescent Cells Reduced

Chloride Channel Gene (CLCN6) Identified As Disease Gene for Severe Form of Lysosomal Neurodegenerative Disease

Phase 2 Trial of Oxford COVID-19 Vaccine in Healthy Older Adults Finds It Is Safe and Provokes Immune Response; Similar Results Seen in Younger Adults; Phase 3 Trials Ongoing

Researchers Discover a Cellular Mechanism for Degradation of miRNAs; Finding May Lead to Insights of How to Control This Mechanism and, Ultimately, to Possible Disease Therapies

Yale Professor Argues That MSC-Derived Exosomes, Rather Than MSCs Themselves, May Be Superior Treatment for Cytokine Storm in COVID-19; Also Says Convalescent Plasma Contains Trillions of Exosomes with Unknown Effects and May Interfere with Antibodie

Moderna’s COVID-19 Vaccine Candidate Meets Primary Efficacy Endpoint in First Interim Analysis of Phase 3 COVE Study; Vaccine Shows 94.5% Efficacy in Early Results

Leronlimab Treatment Inhibits CCR5 in Critically Ill COVID-19 Patients--Decreasing Inflammatory Cytokines, Increasing CD8 T-Cells, and Decreasing SARS-CoV-2 RNA in Plasma by Day 14

Why Does COVID-19 Seem to Spare Children? Research Shows Lower Expression of Key TMPRSS2 Enzyme Used to Aid Viral Fusion to Target Cells

Dublin Researcher Wins 2020 AbbVie Innovation Award to Develop Biomarkers for Multiple Sclerosis

Two Targeted Therapies Being Developed to Treat Idiopathic Pulmonary FIbrosis (IPF)

Researchers Find New "Overlapping Gene" in COVID-19 Virus; Same Gene (ORF3d) Has Been Identified in Coronavirus from Pangolin Mammals Used in Traditional Chinese Medicine; ORF3d Gene Product Produces Strong Antibody Response In COVID-19 Pat

Discovery in Rare Neonatal Diabetes May Offer Clues to Common Diabetes Affecting Millions; Mutations in YIPF1 Gene Found to Cause Rare Neonatal Diabetes; Gene Essential for Insulin-Producing Beta Cells; Malfunction Causes Fatal Cell Stress

Lilly's Neutralizing Anti-Spike-Protein Antibody Bamlanivimab (LY-Cov555) Receives FDA Emergency Use Authorization for Treatment of Recently Diagnosed COVID-19 in High-Risk Patients

Vaccine Candidate Against COVID-19 Achieves Greater Than 90% Effectiveness in First Interim Analysis from Ongoing Phase 3 Study, Pfizer and BioNTech Announce; "Great Day for Science & Humanity," Pfizer CEO States

Bacterial Origins of Trench Fever in Humans Traced Back Centuries by Real-Time PCR-Based DNA Analysis of Ancient Remains; Remnants of Infections Demonstrated in Civilians As Well As Soldiers

Hyperacylation of Key Enzymes in Pathways Known to Be Dysregulated In MMA (Methylmalonic Acidemia ) Likely Contributes to Altered Metabolism and Identifies New Set of Targets for Therapeutic Intervention

Dramatic Clinical Improvement Described in Rare Skin Disease (ILVEN) That Has Previously Proved Highly Treatment-Resistant; Treatment Choice Guided by Molecular Genetic Dissection of Disease in Two Patients That Revealed Mosaic Mutations in CARD14 Ge

Inhibition of HDL-Related Protein Improves Survival in Sepsis—Results Presented at American Society of Human Genetics (ASHG) 2020 Virtual Annual Meeting (October 27-30)

MSC-Derived Exosomes and Exosome-Educated Macrophages Can Differentially Improve Ligament Healing

35-Year Mystery of Retrons Solved—Unusual Molecules Combining RNA and DNA Strands Are Part of Bacterial Defense Mechanism Against Phage; Similarities Noted to “Guard” Mechanism Used by Plants

Researches Develop Phenome-Risk Classification Machine Learning Algorithm to Identify Patients Who Are at High Risk for Developmental Stuttering; Results Presented at ASHG 2020 Virtual Annual Meeting (October 27-30)

Study Uncovers Subset of COVID-19 Patients Who Recover Quickly and Sustain Antibodies; Results Published in Cell

National Human Genome Research Institute Publishes New Vision for Human Genomics--NHGRI's 2020 Strategic Vision Describes Opportunities in Human Genomics for Improving Human Health—Vision Published in Nature

Regeneron's Antibody Cocktail Inmazeb® Is First FDA-Approved Treatment for Ebola (Zaire Ebolavirus); Novel Anti-Viral Antibody Medicine Developed Using Same “Rapid Response” Technologies As Regeneron’s Investigational COVID-19 Antibody Combinati

Regeneron's Ongoing COVID-19 Phase 2/3 Outpatient Trial Prospectively Demonstrates REGN-COV2 Antibody Cocktail Significantly Reduced Virus Levels & Reduced Need for Further Medical Attention

Genome-Wide Analysis ID’s Genetic Effects on Reproductive Success & Ongoing Natural Selection at FADS Locus; FADS1/2 Allele Represents Perhaps Only Example of Genetic Variant with Evidence of Both Ancient & Ongoing Selection, Scientists Say a

First Results of COVID-19 Host Genetics Initiative (HGI) Study Announced at ASHG 2020 Virtual Annual Meeting (October 27-30)

Genetics & COVID-19 Pandemic Are Focus of Special Session at ASHG 2020 Virtual Annual Meeting (October 27-30); On Wednesday, Six Researchers Reported Recent Data on Susceptibility and Severity in“Late-Breaking COVID-19 Research Update” Session

Boehringer Ingelheim Begins Phase 2 Clinical Trial of Targeted Therapy to Help People with Severe Respiratory Illness from COVID-19

Tuesday’s Opening of ASHG 2020 Virtual Annual Meeting (October 27-30) Features Report of Research That Is Described in NEJM Article Published Today--“Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease”

Study Reveals 33% Higher Relative Odds of Penicillin Allergy Associated with HLA-B*55:01 Allele in European Population; Insights into Genetic Architecture of Penicillin Allergy Described in Abstract at ASHG 2020 Virtual Annual Meeting (October 27-30)

American Society of Human Genetics Describes Epstein Trainee Awards (18 Finalists & 42 Semi-Finalists) for Excellence in Human Genetics Research at ASHG 2020 Virtual Annual Meeting (October 27-30); 6 Winners to Be Announced

Cell-Free DNA Provides Dynamic Window into Health; Results Described in Abstract at American Society of Human Genetics 2020 Virtual Annual Meeting (October 27-30)

2020 Cotterman Awards Recognize Two Outstanding Recent Articles in the American Journal of Human Genetics in Which First Authors Are Young Trainees and Members of the ASHG; Awards Described at ASHG 2020 Virtual Annual Meeting (October 27-30)

American Society of Human Genetics Honors Benjamin Neale, PhD, with ASHG 2020 Early-Career Award at ASHG 2020 Virtual Annual Meeting (October 27-30)

American Society of Human Genetics Honors Josée Dupuis, PhD, with the ASHG 2020 Mentorship Award, at ASHG 2020 Virtual Annual Meeting (October 27-30)

American Society of Human Genetics Honors Kenneth Lange, PhD, with the ASHG 2020 Arno Motulsky-Barton Childs Award for Excellence in Human Genetics Education, at ASHG 2020 Virtual Annual Meeting (October 27-30)

American Society of Human Genetics Honors Janina Jeff, PhD, with 2020 Advocacy Award for“In Those Genes” Podcast and Other Inspirational Efforts, at ASHG 2020 Virtual Annual Meeting (October 27-30)

American Society of Human Genetics Honors Fowzan S. Alkuraya, MD, with the ASHG 2020 Curt Stern Award for Significant Scientific Contributions in Past Decade, at ASHG 2020 Virtual Annual Meeting (October 27-30)