Terkko Navigator / Bioorganic & Medicinal Chemistry Letters

Synthesis and biological evaluation of new 2‑substituted‑4‑amino-quinolines and -quinazoline as potential antifungal agents

Design, synthesis, and bioactivity evaluation of macrocyclic benzo[b]pyrido[4,3-e][1,4]oxazine derivatives as novel Pim-1 kinase inhibitors

A photoactivatable self-localizing ligand with improved photosensitivity for chemo-optogenetic control of protein localization in living cells

Iodophenyl-conjugated closo-dodecaborate as a promising small boron molecule that binds to serum albumin and accumulates in tumor

Discovery and preclinical evaluations of JBD0131, a novel nitrodihydro-imidazooxazole anti-tuberculosis agent

Discovery of 2-thiobenzimidazoles as noncovalent inhibitors of SARS-CoV-2 main protease

Synthesis and biological evaluation of niclosamide PROTACs

Discovery of benzyloxyphenyl- and phenethylphenyl-imidazole derivatives as a new class of ante–drug type boosters

Evaluation of aminopyrrolidine amide to improve chloride transport in CFTR-defective cells

Design, synthesis and properties of peptide inhibitors based on BRCA1856-871

Synthesis of baicalein derivatives and evaluation of their antiviral activity against arboviruses

Identification and in vitro characterization of a new series of potent and highly selective G9a inhibitors as novel anti-fibroadipogenic agents

Design, synthesis and biological evaluation of novel aminopropylcarboxamide derivatives as sigma ligands

Synthesis of biotinylated-LPG as a chemical biology tool enabling discovery of ALCAT1 modulators

Synthesis and evaluation of Diaza-Crown Ether-Backboned chelator containing hydroxamate groups for Zr-89 chelation chemistry

Exploration of 4-(1H-indol-3-yl)cyclohex-3-en-1-amine analogues as HDAC inhibitors: Design, synthesis, biological evaluation and modelling studies

Design, synthesis and evaluation of the Brigatinib analogues as potent inhibitors against tertiary EGFR mutants (EGFRdel19/T790M/C797S and EGFRL858R/T790M/C797S)

Discovery and SAR of 4-aminopyrrolidine-2-carboxylic acid correctors of CFTR for the treatment of cystic fibrosis

Optimization of clofibrate with O-desmethyl anetholtrithione lead to a novel hypolipidemia compound with hepatoprotective effect

Identification of small-molecule urea derivatives as PTPC modulators targeting the c subunit of F1/Fo-ATP synthase

Discovery of 5-methyl-1H-benzo[d]imidazole derivatives as novel P2X3 Receptor antagonists

Preparation of a multifunctional photoactivated prodrug on a streptavidin scaffold bearing a DNA aptamer

Fluorescence ratiometric DNA detection by peptide nucleic acid-pyrene binary probes

Discovery of novel indole and indoline derivatives against Candida albicans as potent antifungal agents

Synthesis and initial in vitro evaluation of PSMA-targeting ligands with a modified aromatic moiety at the lysine ε-nitrogen atom

Eukaryotic artificial ON-riboswitches that respond efficiently to mid-sized short peptides

Bioevaluation of a dual PI3K/HDAC inhibitor for the treatment of diffuse large B-cell lymphoma

Design, synthesis and antitumor activity study of PARP-1/HDAC dual targeting inhibitors

Discovery and preclinical profile of sudapyridine (WX-081), a novel anti-tuberculosis agent

Discovery of 4-(3-aminopyrrolidinyl)-3-aryl-5-(benzimidazol-2-yl)-pyridines as potent and selective SST5 agonists for the treatment of congenital hyperinsulinism

Keap 1: The new Janus word on the block

Synthesis of a new series of quinoline/pyridine indole-3-sulfonamide hybrids as selective carbonic anhydrase IX inhibitors

Synthesis and biological evaluation of new series of benzamide derivatives containing urea moiety as sEH inhibitors

Development of pyrazolo[3,4-d]pyrimidin-4-one scaffold as novel CDK2 inhibitors: Design, synthesis, and biological evaluation

Design, synthesis, and in vivo evaluation of GO-SWL-Ahx-K-SWL

Benzoselenazolium-based hemicyanine dye for G-Quadruplex detection

Synthesis, in vitro, in silico and in vivo hypoglycemic and lipid-lowering effects of 4-benzyloxy-5-benzylidene-1,3-thiazolidine-2,4-diones mediated by dual PPAR α/γ modulation

Comparison of three zinc binding groups for HDAC inhibitors – A potency, selectivity and enzymatic kinetics study

New pyrazole-tetrazole hybrid compounds as potent α-amylase and non-enzymatic glycation inhibitors

Synthesis of novel immunomodulatory 1,4-disubstituted bis-1,2,3-triazoles by using click chemistry and their intracellular mechanism of action

Design, synthesis and biological evaluation of chromone derivatives as novel protein kinase CK2 inhibitors

Discovery of (2-phenylthiazol-4-yl)urea derivatives that induce neuronal differentiation from mesenchymal stem cells

Surprising lipophilicity observations identify unexpected conformational effects

2,3-Dihydrobenzo-dioxine piperidine derivatives as potent and selective α2c antagonists

Design, synthesis, and bio-evaluation of novel triterpenoid derivatives as anti-HIV-1 compounds

Insights into the structure–activity relationship of a type III secretion system inhibitor, aurodox

Discovery of 1′-(1-phenylcyclopropane-carbonyl)-3H-spiro[isobenzofuran-1,3′-pyrrolidin]-3-one as a novel steroid mimetic scaffold for the potent and tissue-specific inhibition of 11β-HSD1 using a scaffold-hopping approach

Designer peptides as versatile building blocks for functional materials

Identification of novel indole derivatives as highly potent AMPK activators with anti-diabetic profiles

Discovery of novel benzothiophene derivatives as potent and narrow spectrum inhibitors of DYRK1A and DYRK1B