Table of Contents

Front Matter.
Outlook of the Antiviral Drug Era, Now More Than 50 Years after Description of the First Antiviral Drug / Erik De Clercq.
Inhibition of HIV Entry / Još A Esť.
Targeting Integration beyond Strand Transfer: Development of Second-Generation HIV Integrase Inhibitors / Arnout R D Voet, Marc De Maeyer, Frauke Christ, Zeger Debyser.
From Saquinavir to Darunavir: The Impact of 10 Years of Medicinal Chemistry on a Lethal Disease / Marie-Pierre de B̌thune, Anik Peeters, Piet Wigerinck.
Acyclic and Cyclic Nucleoside Phosphonates / Richard L Mackman, Tomas Cihlar.
Helicase₆Primase Inhibitors: A New Approach to Combat Herpes Simplex Virus and Varicella Zoster Virus / Subhajit Biswas, Hugh J Field.
Cyclophilin Inhibitors / Gřgoire Vuagniaux, Arnaud Hamel, Rafael Crabb̌, Herv̌ C Porchet, Jean-Maurice Dumont.
Alkoxyalkyl Ester Prodrugs of Antiviral Nucleoside Phosphates and Phosphonates / James R Beadle, Karl Y Hostetler.
Maribavir: A Novel Benzimidazole Ribonucleoside for the Prevention and Treatment of Cytomegalovirus Diseases / Karen K Biron.
Anti-HCMV Compounds / Graciela Andrei, Robert Snoeck.
Lethal Mutagenesis as an Unconventional Approach to Combat HIV / Pinar Iyidogan, Karen S Anderson.
Recent Progress in the Development of HCV Protease Inhibitors / Nagraj Mani, Bhisetti G Rao, Tara L Kieffer, Ann D Kwong.
Antiviral RNAi: How to Silence Viruses / Karin J von Eije, Ben Berkhout.
Neuraminidase Inhibitors as Anti-Influenza Agents / Willard Lew, Michael Z Wang, Xiaowu Chen, James F Rooney, Choung Kim.
From TIBO to Rilpivirine: The Chronicle of the Discovery of the Ideal Nonnucleoside Reverse Transcriptase Inhibitor / Erik De Clercq.