Table of Contents

Definition and criteria for the diagnoses of anaphylaxis.
An epidemiological approach to reducing the risk of fatal anaphylaxis.
Pathophysiology and organ damage in anaphylaxis.
Mast cells: effector cells of anaphylaxis.
Basophils in anaphylaxis.
Protease mediators of anaphylaxis.
Aspirin and NSAID reactions: diagnosis, pathophysiology, and management.
IgE-dependent and independent effector mechanisms in human and murine anaphylaxis.
Food-induced anaphylaxis.
Antibiotic-induced anaphylaxis.
Anaphylaxis during radiological procedures and in the peri-operative setting.
Hymenoptera-induced hypersensitivity reactions and anaphylaxis.
Idiopathic anaphylaxis.
Exercise-induced anaphylaxis and food-dependent exercise-induced anaphylaxis.
Mastocytosis and mast cell activation syndromes presenting as anaphylaxis.
Anaphylaxis in mastocytosis.
Flushing and urticarial syndromes presenting as anaphylaxis.
Pharmacologic management of acute anaphylaxis.
Drug desensitizations in the management of allergy and anaphylaxis to chemotherapeutic agents and monoclonal antibodies.
Rapid desensitizations for antibiotic-induced hypersensitivity reactions and anaphylaxis.
Induction of tolerance for food-induced anaphylaxis.
Management of anaphylaxis: relevance of causes and future trends in treatment. Despite wide recognition as a serious public health problem, anaphylaxis and hypersensitivity reactions remain under-recognized and under-diagnosed. This book fills the gaps in our understanding of the identification of triggers, recognition of clinical presentations, understanding of the natural history of these reactions, and selection of treatment strategies including those focused on cellular and molecular targets. The book provides a detailed examination of disease etiology, pathogenesis, and pathophysiology and their correlation to clinical practice. Forefront knowledge of the mediators.