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Gamma Secretase Inhibition for a Child With Metastatic Glomus Tumor and Activated NOTCH1

Identification of potential human beta-secretase 1 inhibitors by hierarchical virtual screening and molecular dynamics

Computational studies on the cholinesterase, beta-secretase 1 (BACE1) and monoamine oxidase (MAO) inhibitory activities of endophytes-derived compounds: towards discovery of novel neurotherapeutics

Genes, Vol. 13, Pages 1059: Alzheimer’s Disease Connected Genes in the Post-Ischemic Hippocampus and Temporal Cortex

Genes, Vol. 13, Pages 1059: Alzheimer’s Disease Connected Genes in the Post-Ischemic Hippocampus and Temporal Cortex

Targeting amyloid precursor protein secretases: Alzheimer's disease and beyond.

Amyloid precursor protein (APP) A673T mutation in the elderly Finnish population.

Amyloid precursor protein (APP) A673T mutation in the elderly Finnish population.

Amyloid precursor protein intracellular domain-dependent regulation of FOXO3a inhibits adult hippocampal neurogenesis.

Molecules, Vol. 25, Pages 5490: Preferred Endocytosis of Amyloid Precursor Protein from Cholesterol-Enriched Lipid Raft Microdomains

GSAP Regulates Amyloid Beta Production through Modulation of Amyloid Precursor Protein Trafficking

Ubiquilin 1 modulates amyloid precursor protein trafficking and Abeta secretion.

The C99 domain of the amyloid precursor protein is a disordered membrane phase-preferring protein

Inhibition of acyl-coenzyme A: cholesterol acyl transferase modulates amyloid precursor protein trafficking in the early secretory pathway.

Amyloid precursor protein (APP) A673T mutation in the elderly Finnish population

Amyloid precursor protein (APP) A673T mutation in the elderly Finnish population

Biomedicines, Vol. 9, Pages 801: Neuronal Trafficking of the Amyloid Precursor Protein—What Do We Really Know?

Cysteine 27 Variant of the {delta}-Opioid Receptor Affects Amyloid Precursor Protein Processing through Altered Endocytic Trafficking.

Cysteine 27 Variant of the {delta}-Opioid Receptor Affects Amyloid Precursor Protein Processing through Altered Endocytic Trafficking.

Cysteine 27 Variant of the {delta}-Opioid Receptor Affects Amyloid Precursor Protein Processing through Altered Endocytic Trafficking.

Fe65 is the sole family member mediating transcription regulated by the amyloid precursor protein.

Distinct anterograde trafficking pathways of BACE1 and amyloid precursor protein from the TGN and the regulation of amyloid-β production.

Early Contextual Fear Memory Deficits in a Double-Transgenic Amyloid-<em>β</em> Precursor Protein/Presenilin 2 Mouse Model of Alzheimer's Disease

APP intracellular domain derived from amyloidogenicβ- and γ-secretase cleavage regulates neprilysin expression.

The <em>Uppsala APP</em> deletion causes early onset autosomal dominant Alzheimer's disease by altering APP processing and increasing amyloidβ fibril formation

Molecules, Vol. 26, Pages 2897: Structural Studies Providing Insights into Production and Conformational Behavior of Amyloid-β Peptide Associated with Alzheimer’s Disease Development

γ-Secretase Genetics of Hidradenitis Suppurativa: A Systematic Literature Review.

Amyloid-β Peptide Impact on Synaptic Function and Neuroepigenetic Gene Control Reveal New Therapeutic Strategies for Alzheimer’s Disease

IJMS, Vol. 23, Pages 507: Specific Mutations in Aph1 Cause &gamma;-Secretase Activation

Base editing strategy allows insertion of the A673T mutation in APP gene to prevent the development of Alzheimer's disease

Design of Transmembrane Mimetic Structural Probes to Trap Different Stages of γ-Secretase-Substrate Interaction

Biomedicines, Vol. 9, Pages 1126: Alzheimer’s Disease: A Molecular View of β-Amyloid Induced Morbific Events

Loss of CDC50A function drives Aβ/p3 production via increased β/α-secretase processing of APP

Early Endosome Capture Proteomics and its Application to Amyloid Precursor Protein Intramembrane Processing by β and γ-Secretases

The orphan drug dichloroacetate reduces amyloid beta-peptide production whilst promoting non-amyloidogenic proteolysis of the amyloid precursor protein

Mechanism of Tripeptide Trimming by γ-Secretase

Adenosine triphosphate Binding Cassette subfamily C member 1 (ABCC1) overexpression reduces APP processing and increases alpha- versus beta-secretase activity, in vitro [RESEARCH ARTICLE]

Molecules, Vol. 26, Pages 7660: Synthesis and Characterization of Andrographolide Derivatives as Regulators of &beta;APP Processing in Human Cells

An isogenic panel of single App knock-in mouse models of Alzheimer's disease confers differential profiles of β-secretase inhibition and endosomal abnormalities

Molecules, Vol. 27, Pages 176: Evaluation of Virtual Screening Strategies for the Identification of &gamma;-Secretase Inhibitors and Modulators

Memantine lowers amyloid-beta peptide levels in neuronal cultures and in APP/PS1 transgenic mice.

Gallic acid is a dual {alpha}/{beta}-secretase modulator that reverses cognitive impairment and remediates pathology in Alzheimer mice [Neurobiology]

Discovery of aryl aminothiazole γ-secretase modulators with novel effects on amyloid β-peptide production

Ubiquilin-1 modulatesγ-secretase-mediated ε-site cleavage in neuronal cells.

Ubiquilin-1 modulatesγ-secretase-mediated ε-site cleavage in neuronal cells.

Biosensors, Vol. 11, Pages 169: Limited Substrate Specificity of PS/γ-Secretase Is Supported by Novel Multiplexed FRET Analysis in Live Cells

Limited Substrate Specificity of PS/γ-Secretase Is Supported by Novel Multiplexed FRET Analysis in Live Cells

Synapse-Associated Protein-97 Mediates {alpha}-Secretase ADAM10 Trafficking and Promotes Its Activity

Chronic oral application of a periodontal pathogen results in brain inflammation, neurodegeneration and amyloid beta production in wild type mice. - PubMed - NCBI

Cells, Vol. 9, Pages 2482: Presynaptic Vesicle Protein SEPTIN5 Regulates the Degradation of APP C-terminal Fragments and the Levels of Aβ